Time to Mammographic Density Decrease After Exposure to Tamoxifen.
breast cancer
breast density
clinical trial
primary prevention
tamoxifen
Journal
The oncologist
ISSN: 1549-490X
Titre abrégé: Oncologist
Pays: England
ID NLM: 9607837
Informations de publication
Date de publication:
05 07 2022
05 07 2022
Historique:
received:
20
11
2020
accepted:
25
10
2021
pubmed:
24
5
2022
medline:
8
7
2022
entrez:
23
5
2022
Statut:
ppublish
Résumé
Mammographic density change has proven to be a reliable proxy for tamoxifen therapy response. The primary aim of this study was to identify time to tamoxifen-induced mammographic density change. We also analyzed side effects and adherence to therapy. In all, 42 women were randomized to 10 or 20 mg of daily oral tamoxifen. Mammograms were taken at baseline, 3, 6, and 9 months. Mammographic density change was measured using the automated STRATUS tool. Adverse events were monitored through a web-based questionnaire based on the FACT-ES tool. Nine out of the 42 (21%) participants discontinued therapy due to adverse events leaving 33 women in the study. A significant decrease in density was seen after 3 months of therapy. Dose did not seem to affect density change, side effects or adherence. Given the size of the study, additional studies are needed to confirm our data.
Identifiants
pubmed: 35605013
pii: 6590851
doi: 10.1093/oncolo/oyac104
pmc: PMC9256030
doi:
Substances chimiques
Tamoxifen
094ZI81Y45
Types de publication
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e601-e603Informations de copyright
© The Author(s) 2022. Published by Oxford University Press.
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