Hesperidin Attenuates Oxidative Stress, Inflammation, Apoptosis, and Cardiac Dysfunction in Sodium Fluoride-Induced Cardiotoxicity in Rats.
Animals
Apoptosis
Beclin-1
/ metabolism
Cardiotoxicity
Caspase 3
/ metabolism
Cytochromes c
/ metabolism
Heart Diseases
/ chemically induced
Hesperidin
/ pharmacology
Inflammation
/ chemically induced
NF-kappa B
/ metabolism
Oxidative Stress
Phosphatidylinositol 3-Kinases
/ adverse effects
Proto-Oncogene Proteins c-akt
/ metabolism
Proto-Oncogene Proteins c-bcl-2
/ metabolism
Rats
Sodium Fluoride
/ toxicity
Superoxide Dismutase
/ metabolism
TOR Serine-Threonine Kinases
/ metabolism
Tumor Necrosis Factor-alpha
/ metabolism
Tumor Suppressor Protein p53
/ metabolism
bcl-2-Associated X Protein
/ metabolism
Apoptosis
Cardiotoxicity
Hesperidin
Oxidative stress
Sodium fluoride
Journal
Cardiovascular toxicology
ISSN: 1559-0259
Titre abrégé: Cardiovasc Toxicol
Pays: United States
ID NLM: 101135818
Informations de publication
Date de publication:
08 2022
08 2022
Historique:
received:
07
03
2022
accepted:
30
04
2022
pubmed:
24
5
2022
medline:
30
6
2022
entrez:
23
5
2022
Statut:
ppublish
Résumé
Excessive fluoride intake has been reported to cause toxicities to brain, thyroid, kidney, liver and testis tissues. Hesperidin (HSP) is an antioxidant that possesses anti-allergenic, anti-carcinogenic, anti-oxidant and anti-inflammatory activities. Presently, the studies focusing on the toxic effects of sodium fluoride (NaF) on heart tissue at biochemical and molecular level are limited. This study was designed to evaluate the ameliorative effects of HSP on toxicity of NaF on the heart of rats in vivo by observing the alterations in oxidative injury markers (MDA, SOD, CAT, GPX and GSH), pro-inflammatory markers (NF-κB, IL-1β, TNF-α), expressions of apoptotic genes (caspase-3, -6, -9, Bax, Bcl-2, p53, cytochrome c), levels of autophagic markers (Beclin 1, LC3A, LC3B), expression levels of PI3K/Akt/mTOR and cardiac markers. HSP treatment attenuated the NaF-induced heart tissue injury by increasing activities of SOD, CAT and GPx and levels of GSH, and suppressing lipid peroxidation. In addition, HSP reversed the changes in expression of apoptotic (caspase-3, -6, -9, Bax, Bcl-2, p53, cytochrome c), levels of autophagic and inflammatory parameters (Beclin 1, LC3A, LC3B, NF-κB, IL-1β, TNF-α), in the NaF-induced cardiotoxicity. HSP also modulated the gene expression levels of PI3K/Akt/mTOR signaling pathway and levels of cardiac markers (LDH, CK-MB). Overall, these findings reveal that HSP treatment can be used for the treatment of NaF-induced cardiotoxicity.
Identifiants
pubmed: 35606666
doi: 10.1007/s12012-022-09751-9
pii: 10.1007/s12012-022-09751-9
doi:
Substances chimiques
Beclin-1
0
NF-kappa B
0
Proto-Oncogene Proteins c-bcl-2
0
Tumor Necrosis Factor-alpha
0
Tumor Suppressor Protein p53
0
bcl-2-Associated X Protein
0
Sodium Fluoride
8ZYQ1474W7
Cytochromes c
9007-43-6
Hesperidin
E750O06Y6O
Superoxide Dismutase
EC 1.15.1.1
Proto-Oncogene Proteins c-akt
EC 2.7.11.1
TOR Serine-Threonine Kinases
EC 2.7.11.1
Caspase 3
EC 3.4.22.-
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
727-735Informations de copyright
© 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
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