Parallel chiral sub/supercritical fluid chromatography screening as a framework for accelerated purification of pharmaceutical targets.
Chiral supercritical fluid chromatography
Enantiomers purification
Enantiopurity analysis
Parallel column screening
Journal
Journal of chromatography. A
ISSN: 1873-3778
Titre abrégé: J Chromatogr A
Pays: Netherlands
ID NLM: 9318488
Informations de publication
Date de publication:
05 Jul 2022
05 Jul 2022
Historique:
received:
15
03
2022
revised:
21
04
2022
accepted:
27
04
2022
pubmed:
25
5
2022
medline:
22
6
2022
entrez:
24
5
2022
Statut:
ppublish
Résumé
Chiral sub/supercritical fluid chromatography (SFC) has established itself as one of the preferred techniques for enantioseparations at both analytical and preparative scale. Herein, we introduce a parallel multicolumn SFC screening for automated chiral method development in fast-paced settings. The practicality and speed advantages of this approach are illustrated with parallel screening of a diverse set of chiral molecules across ten columns with five different organic modifiers/CO
Identifiants
pubmed: 35609494
pii: S0021-9673(22)00287-4
doi: 10.1016/j.chroma.2022.463094
pii:
doi:
Substances chimiques
Indicators and Reagents
0
Pharmaceutical Preparations
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
463094Informations de copyright
Copyright © 2022. Published by Elsevier B.V.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.