Ian Mangion

Affiliations

Merck & Co., Inc., MRL, Analytical Research & Development /Process Research & Development, 126 E. Lincoln Ave., Rahway, NJ, 07065, USA.

Publications (27)

Liposome Artificial Membrane Permeability Assay by MALDI-hydrogen-deuterium exchange mass spectrometry for peptides and small proteins.

Analytica chimica acta

Avec: Alexey A Makarov , Gregory F Pirrone , Vladimir Shchurik , Erik L Regalado , Ian Mangion

Multi-column ultra-high performance liquid chromatography screening with chaotropic agents and computer-assisted separation modeling enables process development of new drug substances.

The Analyst

Avec: Imad A Haidar Ahmad , Wenyong Chen , Holst M Halsey , Artis Klapars , John Limanto , Gregory F Pirrone , Timothy Nowak , Raffeal Bennett , Robert Hartman , Alexey A Makarov , Ian Mangion , Erik L Regalado

Mapping the Separation Landscape in Two-Dimensional Liquid Chromatography: Blueprints for Efficient Analysis and Purification of Pharmaceuticals Enabled by Computer-Assisted Modeling.

Analytical chemistry

Avec: Devin M Makey , Vladimir Shchurik , Heather Wang , Hayley R Lhotka , Dwight R Stoll , Andrey Vazhentsev , Ian Mangion , Erik L Regalado , Imad A Haidar Ahmad

Enantioselective UHPLC Screening Combined with

Analytical chemistry

Avec: Gioacchino Luca Losacco , Heather Wang , Imad A Haidar Ahmad , Jimmy DaSilva , Alexey A Makarov , Ian Mangion , Francesco Gasparrini , Michael Lämmerhofer , Daniel W Armstrong , Erik L Regalado

Successive remodeling of IgG glycans using a solid-phase enzymatic platform.

Communications biology

Avec: Yen-Pang Hsu , Deeptak Verma , Shuwen Sun , Caroline McGregor , Ian Mangion , Benjamin F Mann

Mass Activated Droplet Sorting (MADS) Enables High-Throughput Screening of Enzymatic Reactions at Nanoliter Scale.

Angewandte Chemie (International ed. in English)

Avec: Daniel A Holland-Moritz , Michael K Wismer , Benjamin F Mann , Iman Farasat , Paul Devine , Erik D Guetschow , Ian Mangion , Christopher J Welch , Jeffrey C Moore , Shuwen Sun , Robert T Kennedy

Evaluation of global conformational changes in peptides and proteins following purification by supercritical fluid chromatography.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

Avec: Nicole M Schiavone , Raffeal Bennett , Michael B Hicks , Gregory F Pirrone , Erik L Regalado , Ian Mangion , Alexey A Makarov

Selective Plate-Based Assay for Trace EDTA Analysis via Boron Trifluoride-methanol Derivatization UHPLC-QqQ-MS/MS Enabling Biologic and Vaccine Processes.

Analytical chemistry

Avec: Raffeal Bennett , Ryan D Cohen , Heather Wang , Tony Pereira , Mark A Haverick , John W Loughney , Damon C Barbacci , Pavlo Pristatsky , Amy M Bowman , Gioacchino Luca Losacco , Douglas D Richardson , Ian Mangion , Erik L Regalado

Analytical chemistry

Avec: Imad A Haidar Ahmad , Devin M Makey , Heather Wang , Vladimir Shchurik , Andrew N Singh , Dwight R Stoll , Ian Mangion , Erik L Regalado

Automated ion exchange chromatography screening combined with in silico multifactorial simulation for efficient method development and purification of biopharmaceutical targets.

Analytical and bioanalytical chemistry

Avec: Gioacchino Luca Losacco , Michael B Hicks , Jimmy O DaSilva , Heather Wang , Miraslava Potapenko , Fuh-Rong Tsay , Imad A Haidar Ahmad , Ian Mangion , Davy Guillarme , Erik L Regalado

Parallel chiral sub/supercritical fluid chromatography screening as a framework for accelerated purification of pharmaceutical targets.

Journal of chromatography. A

Avec: Gioacchino Luca Losacco , Jimmy O DaSilva , Imad A Haidar Ahmad , Ian Mangion , Terry A Berger , Erik L Regalado

Use of MALDI-MS with solid-state hydrogen deuterium exchange for semi-automated assessment of peptide and protein physical stability in lyophilized solids.

Analytica chimica acta

Avec: Sneha R Kabaria , Ian Mangion , Alexey A Makarov , Gregory F Pirrone

Charged aerosol detection in early and late-stage pharmaceutical development: selection of regressionmodels at optimum power function value.

Journal of chromatography. A

Avec: Imad A Haidar Ahmad , Andrei Blasko , Heather Wang , Tian Lu , Ian Mangion , Erik L Regalado

The Analyst

Avec: Nicole M Ralbovsky , Randal J Soukup , Justin P Lomont , Mackenzie L Lauro , Amanda Gulasarian , Anumita Saha-Shah , Michael A Winters , Douglas D Richardson , Sheng-Ching Wang , Ian Mangion , Joseph P Smith

Analytical chemistry

Avec: Imad A Haidar Ahmad , Alaina Kiffer , Rodell C Barrientos , Gioacchino Luca Losacco , Andrew Singh , Vladimir Shchurik , Heather Wang , Ian Mangion , Erik L Regalado

Combination of HDX-MS and in silico modeling to study enzymatic reactivity and stereo-selectivity at different solvent conditions.

Journal of pharmaceutical and biomedical analysis

Avec: Alexey A Makarov , Roxana E Iacob , Gregory F Pirrone , Agustina Rodriguez-Granillo , Leo Joyce , Ian Mangion , Jeffrey C Moore , Edward C Sherer , John R Engen

Chaotropic Effects in Sub/Supercritical Fluid Chromatography via Ammonium Hydroxide in Water-Rich Modifiers: Enabling Separation of Peptides and Highly Polar Pharmaceuticals at the Preparative Scale.

Analytical chemistry

Avec: Jinchu Liu , Alexey A Makarov , Raffeal Bennett , Imad A Haidar Ahmad , Jimmy DaSilva , Mikhail Reibarkh , Ian Mangion , Benjamin F Mann , Erik L Regalado

Quantitation and speciation of residual protein within active pharmaceutical ingredients using image analysis with SDS-PAGE.

Journal of pharmaceutical and biomedical analysis

Avec: Joseph P Smith , Nicole M Ralbovsky , Mackenzie L Lauro , Erik Hoyt , Erik D Guetschow , Fengqiang Wang , John A McIntosh , Zhijian Liu , Ian Mangion , Narayan Variankaval , Xiaodong Bu

Utilizing in situ spectroscopic tools to monitor ketal deprotection processes.

International journal of pharmaceutics

Avec: Nicole M Ralbovsky , Justin P Lomont , Serge Ruccolo , Janelle Konietzko , Patrick M McHugh , Sheng-Ching Wang , Ian Mangion , Joseph P Smith

Process monitoring of polysaccharide deketalization for vaccine bioconjugation development using in situ analytical methodology.

Journal of pharmaceutical and biomedical analysis

Avec: Justin P Lomont , Nicole M Ralbovsky , Christine Guza , Anumita Saha-Shah , Joseph Burzynski , Janelle Konietzko , Sheng-Ching Wang , Patrick M McHugh , Ian Mangion , Joseph P Smith

Ultra-high-throughput SPE-MALDI workflow: Blueprint for efficient purification and screening of peptide libraries.

Analytica chimica acta

Avec: Raffeal Bennett , Gregory F Pirrone , Timothy Nowak , Debopreeti Mukherjee , Vladimir Shchurik , Claudio Mapelli , Jennifer L Hickey , Erik L Regalado , Ian Mangion , Alexey A Makarov

Dual-Gradient Unified Chromatography: A New Paradigm for Versatility in Simultaneous Multicomponent Analysis.

Angewandte Chemie (International ed. in English)

Avec: Gioacchino Luca Losacco , Raffeal Bennett , Imad A Haidar Ahmad , Rodell C Barrientos , Jimmy O DaSilva , Yuyang Dong , Alexander W Schuppe , Zeshu Wang , Sheenagh Aiken , Ian Mangion , Varinder K Aggarwal , Erik L Regalado

Automated Hydrophobic Interaction Chromatography Screening Combined with

Analytical chemistry

Avec: Rodell C Barrientos , Gioacchino Luca Losacco , Mohammadmehdi Azizi , Heather Wang , Anh Nguyet Nguyen , Vladimir Shchurik , Andrew Singh , Douglas Richardson , Ian Mangion , Davy Guillarme , Erik L Regalado , Imad A Haidar Ahmad

Combination of circular dichroism spectroscopy and size-exclusion chromatography coupled with HDX-MS for studying global conformational structures of peptides in solution.

Talanta

Avec: Nicole M Schiavone , Gregory F Pirrone , Erik D Guetschow , Ian Mangion , Alexey A Makarov

Generic anion-exchange chromatography method for analytical and preparative separation of nucleotides in the development and manufacture of drug substances.

Journal of chromatography. A

Avec: Fuh-Rong Tsay , Imad A Haidar Ahmad , Derek Henderson , Nicole Schiavone , Zhijian Liu , Alexey A Makarov , Ian Mangion , Erik L Regalado

The Emergence of Universal Chromatographic Methods in the Research and Development of New Drug Substances.

Accounts of chemical research

Avec: Erik L Regalado , Imad A Haidar Ahmad , Raffeal Bennett , Valentina D'Atri , Alexey A Makarov , Guy R Humphrey , Ian Mangion , Davy Guillarme

Use of Raman spectroscopy and size-exclusion chromatography coupled with HDX-MS spectroscopy for studying conformational changes of small proteins in solution.

Journal of pharmaceutical and biomedical analysis

Avec: Rui Wang , Ian Mangion , Alexey A Makarov , Dmitry Kurouski

Réseau de co-auteurs

Erik L Regalado 17 collaborations

Imad A Haidar Ahmad 13 collaborations

Alexey A Makarov 12 collaborations

Heather Wang 8 collaborations

Gregory F Pirrone 7 collaborations

Raffeal Bennett 7 collaborations

Gioacchino Luca Losacco 7 collaborations

Vladimir Shchurik 6 collaborations

Nicole M Ralbovsky 4 collaborations

Joseph P Smith 4 collaborations

Benjamin F Mann 3 collaborations

Erik D Guetschow 3 collaborations

Jimmy O DaSilva 3 collaborations

Davy Guillarme 3 collaborations

Justin P Lomont 3 collaborations

Sheng-Ching Wang 3 collaborations

Rodell C Barrientos 3 collaborations

Timothy Nowak 2 collaborations

Devin M Makey 2 collaborations

Dwight R Stoll 2 collaborations

Jimmy DaSilva 2 collaborations

Shuwen Sun 2 collaborations

Jeffrey C Moore 2 collaborations

Nicole M Schiavone 2 collaborations

Michael B Hicks 2 collaborations

Douglas D Richardson 2 collaborations

Fuh-Rong Tsay 2 collaborations

Mackenzie L Lauro 2 collaborations

Anumita Saha-Shah 2 collaborations

Andrew Singh 2 collaborations

Zhijian Liu 2 collaborations

Janelle Konietzko 2 collaborations

Patrick M McHugh 2 collaborations

Wenyong Chen 1 collaboration

Holst M Halsey 1 collaboration

Artis Klapars 1 collaboration

John Limanto 1 collaboration

Robert Hartman 1 collaboration

Hayley R Lhotka 1 collaboration

Andrey Vazhentsev 1 collaboration

Francesco Gasparrini 1 collaboration

Michael Lämmerhofer 1 collaboration

Daniel W Armstrong 1 collaboration

Yen-Pang Hsu 1 collaboration

Deeptak Verma 1 collaboration

Caroline McGregor 1 collaboration

Daniel A Holland-Moritz 1 collaboration

Michael K Wismer 1 collaboration

Iman Farasat 1 collaboration

Paul Devine 1 collaboration

Christopher J Welch 1 collaboration

Robert T Kennedy 1 collaboration

Ryan D Cohen 1 collaboration

Tony Pereira 1 collaboration

Mark A Haverick 1 collaboration

John W Loughney 1 collaboration

Damon C Barbacci 1 collaboration

Pavlo Pristatsky 1 collaboration

Amy M Bowman 1 collaboration

Andrew N Singh 1 collaboration

Miraslava Potapenko 1 collaboration

Terry A Berger 1 collaboration

Sneha R Kabaria 1 collaboration

Andrei Blasko 1 collaboration

Tian Lu 1 collaboration

Randal J Soukup 1 collaboration

Amanda Gulasarian 1 collaboration

Michael A Winters 1 collaboration

Alaina Kiffer 1 collaboration

Roxana E Iacob 1 collaboration

Agustina Rodriguez-Granillo 1 collaboration

Leo Joyce 1 collaboration

Edward C Sherer 1 collaboration

John R Engen 1 collaboration

Jinchu Liu 1 collaboration

Mikhail Reibarkh 1 collaboration

Erik Hoyt 1 collaboration

Fengqiang Wang 1 collaboration

John A McIntosh 1 collaboration

Narayan Variankaval 1 collaboration

Xiaodong Bu 1 collaboration

Serge Ruccolo 1 collaboration

Christine Guza 1 collaboration

Joseph Burzynski 1 collaboration

Debopreeti Mukherjee 1 collaboration

Claudio Mapelli 1 collaboration

Jennifer L Hickey 1 collaboration

Yuyang Dong 1 collaboration

Alexander W Schuppe 1 collaboration

Zeshu Wang 1 collaboration

Sheenagh Aiken 1 collaboration

Varinder K Aggarwal 1 collaboration

Mohammadmehdi Azizi 1 collaboration

Anh Nguyet Nguyen 1 collaboration

Douglas Richardson 1 collaboration

Derek Henderson 1 collaboration

Nicole Schiavone 1 collaboration

Valentina D'Atri 1 collaboration

Guy R Humphrey 1 collaboration

Rui Wang 1 collaboration

Dmitry Kurouski 1 collaboration