How fungal multidrug transporters mediate hyper resistance through DNA amplification and mutation.
Journal
Molecular microbiology
ISSN: 1365-2958
Titre abrégé: Mol Microbiol
Pays: England
ID NLM: 8712028
Informations de publication
Date de publication:
07 2022
07 2022
Historique:
revised:
18
05
2022
received:
25
03
2022
accepted:
21
05
2022
pubmed:
26
5
2022
medline:
14
7
2022
entrez:
25
5
2022
Statut:
ppublish
Résumé
A significant portion of clinically observed antifungal resistance is mediated by ATP-binding cassette (ABC) and major facilitator superfamily (MFS) transport pumps that reside in the plasma membrane. We review the mechanisms responsible for this phenomenon. Hyper resistance is often brought about by several kinds of DNA amplification or by gain-of-function mutations in a variety of transcription factors. Both of these result in overexpression of ABC and MFS transporters. Recently, however, several additional modes of resistance have been observed. These include mutations in non-conserved nucleotides leading to altered mRNA stability and a mutation in yeast transporter Pdr5, which improves cooperativity between drug-binding sites.
Substances chimiques
ATP-Binding Cassette Transporters
0
Antifungal Agents
0
Membrane Transport Proteins
0
Saccharomyces cerevisiae Proteins
0
DNA
9007-49-2
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
3-15Informations de copyright
© 2022 John Wiley & Sons Ltd.
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