Application of 7T MRS to High-Grade Gliomas.

Humans Brain Neoplasms / pathology Isocitrate Dehydrogenase Glioma / pathology Magnetic Resonance Spectroscopy / methods Magnetic Resonance Imaging / methods

Journal

AJNR. American journal of neuroradiology
ISSN: 1936-959X
Titre abrégé: AJNR Am J Neuroradiol
Pays: United States
ID NLM: 8003708

Informations de publication

Date de publication:
10 2022
Historique:
received: 03 11 2021
accepted: 11 02 2022
pubmed: 27 5 2022
medline: 30 12 2022
entrez: 26 5 2022
Statut: ppublish

Résumé

MRS, including single-voxel spectroscopy and MR spectroscopic imaging, captures metabolites in high-grade gliomas. Emerging evidence indicates that 7T MRS may be more sensitive to aberrant metabolic activity than lower-field strength MRS. However, the literature on the use of 7T MRS to visualize high-grade gliomas has not been summarized. We aimed to identify metabolic information provided by 7T MRS, optimal spectroscopic sequences, and areas for improvement in and new applications for 7T MRS. Literature was found on PubMed using "high-grade glioma," "malignant glioma," "glioblastoma," "anaplastic astrocytoma," "7T," "MR spectroscopy," and "MR spectroscopic imaging." 7T MRS offers higher SNR, modestly improved spatial resolution, and better resolution of overlapping resonances. 7T MRS also yields reduced Cramér-Rao lower bound values. These features help to quantify D-2-hydroxyglutarate in

Identifiants

DOI: 10.3174/ajnr.A7502 PMID: 35618424 PMC: PMC9575545
pubmed: 35618424
pii: ajnr.A7502
doi: 10.3174/ajnr.A7502
pmc: PMC9575545
doi:

Substances chimiques

Isocitrate Dehydrogenase EC 1.1.1.41

Types de publication

Journal Article Review Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

1378-1395

Subventions

Organisme : NCI NIH HHS
ID : R01 CA202911
Pays : United States

Informations de copyright

© 2022 by American Journal of Neuroradiology.

Auteurs

L McCarthy (L)

From the Department of Neurosurgery (L.M., C.G.H.), Icahn School of Medicine at Mount Sinai, Mount Sinai Health System, New York, New York lily.mccarthy@icahn.mssm.edu.
ORCID: 0000-0003-2079-0612

G Verma (G)

BioMedical Engineering and Imaging Institute (G.V., P.B.), Icahn School of Medicine at Mount Sinai, New York, New York.
ORCID: 0000-0002-7157-439X

G Hangel (G)

Department of Neurosurgery (G.H.).
High-field MR Center (G.H.), Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, Vienna, Austria.
ORCID: 0000-0002-3986-3159

A Neal (A)

Department of Medicine (A.N.), Royal Melbourne Hospital, University of Melbourne, Melbourne, Australia.
Department of Neurology (A.N.), Royal Melbourne Hospital, Melbourne, Australia.
ORCID: 0000-0001-9251-5471

B A Moffat (BA)

The Melbourne Brain Centre Imaging Unit (B.A.M.), Department of Radiology, The University of Melbourne, Melbourne, Australia.
ORCID: 0000-0002-0278-4801

J P Stockmann (JP)

A. A. Martinos Center for Biomedical Imaging (J.P.S., O.C.A.), Massachusetts General Hospital, Charlestown, Massachusetts.
Harvard Medical School (J.P.S., O.C.A.), Boston, Massachusetts.
ORCID: 0000-0001-8454-5347

O C Andronesi (OC)

A. A. Martinos Center for Biomedical Imaging (J.P.S., O.C.A.), Massachusetts General Hospital, Charlestown, Massachusetts.
Harvard Medical School (J.P.S., O.C.A.), Boston, Massachusetts.
ORCID: 0000-0002-7412-0641

P Balchandani (P)

BioMedical Engineering and Imaging Institute (G.V., P.B.), Icahn School of Medicine at Mount Sinai, New York, New York.
ORCID: 0000-0001-7709-5835

C G Hadjipanayis (CG)

From the Department of Neurosurgery (L.M., C.G.H.), Icahn School of Medicine at Mount Sinai, Mount Sinai Health System, New York, New York.
ORCID: 0000-0001-8615-6644

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Application of 7T MRS to High-Grade Gliomas.
questionsmedicales.fr › Maladies du système nerveux › Tumeurs du système nerveux › Tumeurs du système nerveux central › Tumeurs du cerveau › Application of 7T MRS to High-Grade Gliomas.
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Oxidoreductases › Alcohol oxidoreductases › NAD (+) and NADP (+) dependent Alcohol oxidoreductases › Isocitrate dehydrogenases › Application of 7T MRS to High-Grade Gliomas.
questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Tumeurs du tissu nerveux › Tumeurs neuroectodermiques › Tumeurs neuroépitheliales › Gliome › Application of 7T MRS to High-Grade Gliomas.
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Analyse spectrale › Spectroscopie par résonance magnétique › Application of 7T MRS to High-Grade Gliomas.
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Imagerie diagnostique › Tomographie › Imagerie par résonance magnétique › Application of 7T MRS to High-Grade Gliomas.