Prolonged contextual fear memory in AMPA receptor palmitoylation-deficient mice.
Journal
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
ISSN: 1740-634X
Titre abrégé: Neuropsychopharmacology
Pays: England
ID NLM: 8904907
Informations de publication
Date de publication:
11 2022
11 2022
Historique:
received:
13
12
2021
accepted:
07
05
2022
revised:
26
04
2022
pubmed:
27
5
2022
medline:
15
10
2022
entrez:
26
5
2022
Statut:
ppublish
Résumé
Long-lasting fear-related disorders depend on the excessive retention of traumatic fear memory. We previously showed that the palmitoylation-dependent removal of synaptic α-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptors prevents hyperexcitation-based epileptic seizures and that AMPA receptor palmitoylation maintains neural network stability. In this study, AMPA receptor subunit GluA1 C-terminal palmitoylation-deficient (GluA1C811S) mice were subjected to comprehensive behavioral battery tests to further examine whether the mutation causes other neuropsychiatric disease-like symptoms. The behavioral analyses revealed that palmitoylation-deficiency in GluA1 is responsible for characteristic prolonged contextual fear memory formation, whereas GluA1C811S mice showed no impairment of anxiety-like behaviors at the basal state. In addition, fear generalization gradually increased in these mutant mice without affecting their cued fear. Furthermore, fear extinction training by repeated exposure of mice to conditioned stimuli had little effect on GluA1C811S mice, which is in line with augmentation of synaptic transmission in pyramidal neurons in the basolateral amygdala. In contrast, locomotion, sociability, depression-related behaviors, and spatial learning and memory were unaffected by the GluA1 non-palmitoylation mutation. These results indicate that impairment of AMPA receptor palmitoylation specifically causes posttraumatic stress disorder (PTSD)-like symptoms.
Identifiants
pubmed: 35618841
doi: 10.1038/s41386-022-01347-9
pii: 10.1038/s41386-022-01347-9
pmc: PMC9556755
doi:
Substances chimiques
Propionates
0
Receptors, AMPA
0
alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid
77521-29-0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2150-2159Informations de copyright
© 2022. The Author(s).
Références
Clin Psychol Rev. 2017 Aug;56:106-121
pubmed: 28734184
Neuropsychopharmacology. 2008 Jan;33(1):56-72
pubmed: 17882236
Annu Rev Cell Dev Biol. 2007;23:613-43
pubmed: 17506699
Cell. 2011 Oct 28;147(3):509-24
pubmed: 22036561
Neuron. 2018 Oct 24;100(2):314-329
pubmed: 30359599
Physiol Behav. 2010 Mar 3;99(3):301-16
pubmed: 19931548
Bioessays. 2013 Nov;35(11):929-39
pubmed: 23943381
Dialogues Clin Neurosci. 2015 Sep;17(3):337-46
pubmed: 26487814
Nature. 2008 Jul 31;454(7204):642-5
pubmed: 18615014
J Neurosci. 2000 Nov 1;20(21):7932-40
pubmed: 11050113
Hippocampus. 2001;11(6):763-75
pubmed: 11811671
Ann N Y Acad Sci. 2006 Nov;1086:144-59
pubmed: 17185513
Nat Rev Neurosci. 2007 Feb;8(2):101-13
pubmed: 17237803
J Neurosci. 2018 Nov 21;38(47):10220-10235
pubmed: 30355633
Biol Psychol. 2006 Jul;73(1):61-71
pubmed: 16476517
J Neurosci. 2013 Sep 25;33(39):15401-7
pubmed: 24068808
Neuropsychopharmacology. 2009 Nov;34(12):2574-84
pubmed: 19675539
Front Mol Neurosci. 2019 Jan 31;12:8
pubmed: 30766476
Neurosignals. 2006-2007;15(5):266-82
pubmed: 17622793
Nat Rev Neurosci. 2013 Jun;14(6):417-28
pubmed: 23635870
Nat Neurosci. 2009 Jul;12(7):879-87
pubmed: 19503082
Science. 2010 Nov 19;330(6007):1108-12
pubmed: 21030604
Neuron. 2009 Feb 12;61(3):340-50
pubmed: 19217372
Nat Neurosci. 2018 Mar;21(3):384-392
pubmed: 29403033
Front Pharmacol. 2021 Aug 18;12:711737
pubmed: 34483921
Neuron. 2007 Feb 15;53(4):519-33
pubmed: 17296554
Front Mol Neurosci. 2021 Nov 15;14:796912
pubmed: 34867194
Br J Pharmacol. 2021 Feb;178(4):784-797
pubmed: 32159240
Nat Neurosci. 2018 May;21(5):654-658
pubmed: 29686260
Physiol Rev. 2003 Jul;83(3):803-34
pubmed: 12843409
Neuropharmacology. 2012 Feb;62(2):638-46
pubmed: 21782833
J Neurosci Methods. 1985 Aug;14(3):149-67
pubmed: 2864480
Nat Neurosci. 2011 Sep 11;14(10):1302-8
pubmed: 21909089
Sci STKE. 2006 Oct 31;2006(359):re14
pubmed: 17077383
Nat Rev Mol Cell Biol. 2007 Jan;8(1):74-84
pubmed: 17183362
J Toxicol Sci. 2009;34 Suppl 2:SP293-305
pubmed: 19571483
Front Behav Neurosci. 2019 Jan 15;12:329
pubmed: 30697153
Biol Psychiatry. 2006 Aug 15;60(4):376-82
pubmed: 16919525
Nature. 2008 Dec 18;456(7224):904-9
pubmed: 19092927
J Biol Chem. 2015 Nov 27;290(48):28596-603
pubmed: 26453298
Annu Rev Neurosci. 2002;25:103-26
pubmed: 12052905
Front Psychiatry. 2013 May 30;4:46
pubmed: 23750137
Nat Rev Neurosci. 2010 Mar;11(3):161-75
pubmed: 20168314
Neuropsychopharmacol Rep. 2019 Mar;39(1):61-66
pubmed: 30536651
Pharmacol Biochem Behav. 1996 May;54(1):31-40
pubmed: 8728536
Brain Struct Funct. 2016 Jul;221(6):2937-62
pubmed: 26169110
Nat Neurosci. 2015 Feb;18(2):188-90
pubmed: 25531573
Biochim Biophys Acta. 2016 Nov;1858(11):2662-2670
pubmed: 27424801
Nature. 1997 Dec 11;390(6660):604-7
pubmed: 9403688
Curr Opin Neurobiol. 2012 Jun;22(3):461-9
pubmed: 22217700
Nat Rev Neurosci. 2004 Dec;5(12):952-62
pubmed: 15550950
Arch Gen Psychiatry. 2005 Jun;62(6):593-602
pubmed: 15939837
Front Neural Circuits. 2013 Aug 01;7:129
pubmed: 23914157
Neurosci Res. 2007 Jun;58(2):124-32
pubmed: 17524507
Neuron. 2013 Oct 30;80(3):704-17
pubmed: 24183021
Physiol Behav. 2001 Aug;73(5):705-17
pubmed: 11566205
Neuron. 2005 Sep 1;47(5):709-23
pubmed: 16129400
Nature. 2006 Jun 1;441(7093):595-600
pubmed: 16554754
Physiol Rev. 2016 Apr;96(2):695-750
pubmed: 26983799
Proc Natl Acad Sci U S A. 2008 Dec 30;105(52):20947-52
pubmed: 19098102
J Biol Chem. 2011 Mar 18;286(11):8709-16
pubmed: 21216969
Psychiatr Serv. 2008 Oct;59(10):1184-90
pubmed: 18832505
Neurosci Lett. 2011 Jan 25;488(3):242-6
pubmed: 21094221
Biol Psychiatry. 2021 May 1;89(9):847-856
pubmed: 33691931
J Neurosci. 2001 Jul 15;21(14):5239-50
pubmed: 11438599
Curr Psychiatry Rep. 2020 Mar 3;22(4):19
pubmed: 32125541
Behav Res Ther. 2001 Oct;39(10):1183-97
pubmed: 11579988
Physiol Genomics. 2008 Aug 15;34(3):243-55
pubmed: 18505770
Front Neuroanat. 2021 Dec 09;15:786679
pubmed: 34955766
Nature. 1997 Dec 11;390(6660):607-11
pubmed: 9403689
Neuron. 2012 Feb 9;73(3):482-96
pubmed: 22325201
Brain Sci. 2021 Apr 20;11(4):
pubmed: 33924037
Neuron. 2013 Dec 18;80(6):1491-507
pubmed: 24290204