Genetic basis of job attainment characteristics and the genetic sharing with other SES indices and well-being.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
26 05 2022
26 05 2022
Historique:
received:
03
11
2021
accepted:
07
04
2022
entrez:
26
5
2022
pubmed:
27
5
2022
medline:
31
5
2022
Statut:
epublish
Résumé
Job attainment is an important component of socioeconomic status (SES). There is currently a paucity of genomic research on an individual's job attainment, as well as how it is related to other SES variables and overall well-being at the whole genome level. By incorporating O*NET occupational information into the UK Biobank database, we performed GWAS analyses of six major job attainment characteristics-job complexity, autonomy, innovation, information demands, emotional demands, and physical demands-on 219,483 individuals of European ancestry. The job attainment characteristics had moderate to high pairwise genetic correlations, manifested by three latent factors: cognitive, emotional, and physical requirements. The latent factor of overall job requirement underlying the job attainment traits represented a critical genetic path from educational attainment to income (P < 0.001). Job attainment characteristics were genetically positively correlated with positive health and well-being outcomes (i.e., subject well-being, overall health rating, number of non-cancer illnesses etc. (|r
Identifiants
pubmed: 35618877
doi: 10.1038/s41598-022-12905-y
pii: 10.1038/s41598-022-12905-y
pmc: PMC9135765
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
8902Subventions
Organisme : Medical Research Council
ID : MC_PC_17228
Pays : United Kingdom
Organisme : NIA NIH HHS
ID : U01 AG071450
Pays : United States
Organisme : NICHD NIH HHS
ID : P01 HD031921
Pays : United States
Organisme : NIA NIH HHS
ID : U01 AG071448
Pays : United States
Organisme : Medical Research Council
ID : MC_QA137853
Pays : United Kingdom
Informations de copyright
© 2022. The Author(s).
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