Cost-effectiveness of the MitraClip device in German heart failure patients with secondary mitral regurgitation.
Cost-effectiveness
Germany
Heart failure
MitraClip
Secondary mitral regurgitation
Transcatheter-valve repair
Journal
The European journal of health economics : HEPAC : health economics in prevention and care
ISSN: 1618-7601
Titre abrégé: Eur J Health Econ
Pays: Germany
ID NLM: 101134867
Informations de publication
Date de publication:
Apr 2023
Apr 2023
Historique:
received:
25
06
2021
accepted:
28
04
2022
medline:
31
3
2023
pubmed:
28
5
2022
entrez:
27
5
2022
Statut:
ppublish
Résumé
To evaluate the cost-effectiveness of the MitraClip device (MitraClip) in addition to optimal medical therapy (OMT) in patients with heart failure and secondary mitral regurgitation in Germany. A model-based economic evaluation was performed to estimate the incremental cost per quality-adjusted life-years (QALYs) for patients with a moderate-to-severe or severe secondary mitral regurgitation receiving MitraClip plus OMT compared with OMT alone from the statutory health insurance (SHI) perspective. Transition probabilities, data on survival rates, and hospitalization rates were obtained from the COAPT trial, a randomized-controlled multicenter trial. Data on health utility and costs were taken from published evidence. To assess parameter uncertainty, several deterministic and probabilistic sensitivity analyses were performed. The incremental costs per QALY gained were € 59,728 (costs/incremental life years gained: € 42,360). The results were most sensitive to the transition probabilities and the hospitalization rates. The probabilistic sensitivity analysis showed that the MitraClip strategy was cost-effective with a probability of 80% at a willingness-to-pay threshold of € 67,000/QALY. Depending on the willingness-to-pay threshold, for patients with heart failure and a moderate-to-severe or severe secondary mitral regurgitation the MitraClip can be cost-effective from the perspective of the German SHI.
Identifiants
pubmed: 35622185
doi: 10.1007/s10198-022-01476-4
pii: 10.1007/s10198-022-01476-4
pmc: PMC10060324
doi:
Types de publication
Randomized Controlled Trial
Multicenter Study
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
349-358Commentaires et corrections
Type : CommentIn
Informations de copyright
© 2022. The Author(s).
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