Cross-reactive immunity against the SARS-CoV-2 Omicron variant is low in pediatric patients with prior COVID-19 or MIS-C.

Adolescent Antibodies, Viral COVID-19 / complications Child Child, Preschool Humans Membrane Glycoproteins Neutralization Tests SARS-CoV-2 Spike Glycoprotein, Coronavirus Systemic Inflammatory Response Syndrome Viral Envelope Proteins

Journal

Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555

Informations de publication

Date de publication:
27 05 2022
Historique:
received: 18 03 2022
accepted: 10 05 2022
entrez: 27 5 2022
pubmed: 28 5 2022
medline: 1 6 2022
Statut: epublish

Résumé

Neutralization capacity of antibodies against Omicron after a prior SARS-CoV-2 infection in children and adolescents is not well studied. Therefore, we evaluated virus-neutralizing capacity against SARS-CoV-2 Alpha, Beta, Gamma, Delta and Omicron variants by age-stratified analyses (<5, 5-11, 12-21 years) in 177 pediatric patients hospitalized with severe acute COVID-19, acute MIS-C, and in convalescent samples of outpatients with mild COVID-19 during 2020 and early 2021. Across all patients, less than 10% show neutralizing antibody titers against Omicron. Children <5 years of age hospitalized with severe acute COVID-19 have lower neutralizing antibodies to SARS-CoV-2 variants compared with patients >5 years of age. As expected, convalescent pediatric COVID-19 and MIS-C cohorts demonstrate higher neutralization titers than hospitalized acute COVID-19 patients. Overall, children and adolescents show some loss of cross-neutralization against all variants, with the most pronounced loss against Omicron. In contrast to SARS-CoV-2 infection, children vaccinated twice demonstrated higher titers against Alpha, Beta, Gamma, Delta and Omicron. These findings can influence transmission, re-infection and the clinical disease outcome from emerging SARS-CoV-2 variants and supports the need for vaccination in children.

Identifiants

DOI: 10.1038/s41467-022-30649-1 PMID: 35624101 PMC: PMC9142524
pubmed: 35624101
doi: 10.1038/s41467-022-30649-1
pii: 10.1038/s41467-022-30649-1
pmc: PMC9142524
doi:

Substances chimiques

Antibodies, Viral 0
Membrane Glycoproteins 0
Spike Glycoprotein, Coronavirus 0
Viral Envelope Proteins 0
spike protein, SARS-CoV-2 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, U.S. Gov't, P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

2979

Subventions

Organisme : NICHD NIH HHS
ID : K23 HD096018
Pays : United States
Organisme : NHLBI NIH HHS
ID : K23 HL146936
Pays : United States
Organisme : NHLBI NIH HHS
ID : K23 HL150244
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI084011
Pays : United States

Commentaires et corrections

Type : ErratumIn

Informations de copyright

© 2022. This is a U.S. government work and not under copyright protection in the U.S.; foreign copyright protection may apply.

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Auteurs

Juanjie Tang (J)

Division of Viral Products, Center for Biologics Evaluation and Research (CBER), FDA, Silver Spring, MD, 20993, USA.

Tanya Novak (T)

Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Boston, MA, 02115, USA.
Department of Anesthesia, Harvard Medical School, Boston, MA, 02115, USA.
ORCID: 0000-0002-7115-7545

Julian Hecker (J)

Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 02115, USA.

Gabrielle Grubbs (G)

Division of Viral Products, Center for Biologics Evaluation and Research (CBER), FDA, Silver Spring, MD, 20993, USA.
ORCID: 0000-0003-4302-9535

Fatema Tuz Zahra (FT)

Division of Viral Products, Center for Biologics Evaluation and Research (CBER), FDA, Silver Spring, MD, 20993, USA.

Lorenza Bellusci (L)

Division of Viral Products, Center for Biologics Evaluation and Research (CBER), FDA, Silver Spring, MD, 20993, USA.

Sara Pourhashemi (S)

Division of Viral Products, Center for Biologics Evaluation and Research (CBER), FDA, Silver Spring, MD, 20993, USA.

Janet Chou (J)

Department of Pediatrics, Boston Children's Hospital and Harvard Medical School, Boston, MA, 02115, USA.
Division of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA, 02115, USA.

Kristin Moffitt (K)

Department of Pediatrics, Boston Children's Hospital and Harvard Medical School, Boston, MA, 02115, USA.
Division of Infectious Diseases, Boston Children's Hospital, Boston, MA, 02115, USA.

Natasha B Halasa (NB)

Division of Pediatric Infectious Diseases, Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, 37232, USA.

Stephanie P Schwartz (SP)

Department of Pediatrics, University of North Carolina at Chapel Hill Children's Hospital, Chapel Hill, NC, 27514, USA.

Tracie C Walker (TC)

Department of Pediatrics, University of North Carolina at Chapel Hill Children's Hospital, Chapel Hill, NC, 27514, USA.

Keiko M Tarquinio (KM)

Division of Critical Care Medicine, Department of Pediatrics, Emory University School of Medicine, Children's Healthcare of Atlanta, Atlanta, GA, 30322, USA.

Matt S Zinter (MS)

Department of Pediatrics, Divisions of Critical Care and Bone Marrow Transplantation, University of California, San Francisco, San Francisco, CA, 94158, USA.
ORCID: 0000-0003-3351-3278

Mary A Staat (MA)

Department of Pediatrics, University of Cincinnati, Division of Infectious Diseases, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 45229, USA.

Shira J Gertz (SJ)

Division of Pediatric Critical Care, Department of Pediatrics, Cooperman Barnabas Medical Center, Livingston, NJ, 07039, USA.

Natalie Z Cvijanovich (NZ)

Division of Critical Care Medicine, UCSF Benioff Children's Hospital Oakland, Oakland, CA, 94609, USA.

Jennifer E Schuster (JE)

Division of Pediatric Infectious Diseases, Department of Pediatrics, Children's Mercy Kansas City, Kansas City, MO, 64108, USA.

Laura L Loftis (LL)

Division of Critical Care Medicine, Department of Pediatrics, Baylor College of Medicine, Houston, TX, 77030, USA.

Bria M Coates (BM)

Division of Critical Care Medicine, Department of Pediatrics, Northwestern University Feinberg School of Medicine, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, 60611, USA.

Elizabeth H Mack (EH)

Division of Pediatric Critical Care Medicine, Medical University of South Carolina, Charleston, SC, 29425, USA.

Katherine Irby (K)

Section of Pediatric Critical Care, Department of Pediatrics, Arkansas Children's Hospital, Little Rock, AR, 72202, USA.
ORCID: 0000-0001-8111-3215

Julie C Fitzgerald (JC)

Division of Critical Care, Department of Anesthesiology and Critical Care, The University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA.

Courtney M Rowan (CM)

Division of Pediatric Critical Care Medicine, Department of Pediatrics, Indiana University School of Medicine, Riley Hospital for Children, Indianapolis, IN, 46202, USA.
ORCID: 0000-0003-1393-6476

Michele Kong (M)

Division of Pediatric Critical Care Medicine, Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL, 35233, USA.

Heidi R Flori (HR)

Division of Pediatric Critical Care Medicine, Department of Pediatrics, Mott Children's Hospital and University of Michigan, Ann Arbor, MI, 48109, USA.

Aline B Maddux (AB)

Department of Pediatrics, Section of Critical Care Medicine, University of Colorado School of Medicine and Children's Hospital Colorado, Aurora, CO, 80045, USA.

Steven L Shein (SL)

Division of Pediatric Critical Care Medicine, Rainbow Babies and Children's Hospital, Cleveland, OH, 44106, USA.
ORCID: 0000-0003-3382-5159

Hillary Crandall (H)

Division of Pediatric Critical Care, Department of Pediatrics, University of Utah, Salt Lake City, UT, 84113, USA.
ORCID: 0000-0002-5392-8457

Janet R Hume (JR)

Division of Pediatric Critical Care, University of Minnesota Masonic Children's Hospital, Minneapolis, MN, 55454, USA.

Charlotte V Hobbs (CV)

Department of Pediatrics, Department of Microbiology, Division of Infectious Diseases, University of Mississippi Medical Center, Jackson, MS, 39202, USA.

Adriana H Tremoulet (AH)

Kawasaki Disease Research Center, Rady Children's Hospital and Department of Pediatrics, UCSD School of Medicine, La Jolla, CA, 92093, USA.

Chisato Shimizu (C)

Kawasaki Disease Research Center, Rady Children's Hospital and Department of Pediatrics, UCSD School of Medicine, La Jolla, CA, 92093, USA.
ORCID: 0000-0002-3149-2699

Jane C Burns (JC)

Kawasaki Disease Research Center, Rady Children's Hospital and Department of Pediatrics, UCSD School of Medicine, La Jolla, CA, 92093, USA.

Sabrina R Chen (SR)

Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Boston, MA, 02115, USA.

Hye Kyung Moon (HK)

Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Boston, MA, 02115, USA.

Christoph Lange (C)

Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, 02115, USA.

Adrienne G Randolph (AG)

Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Boston, MA, 02115, USA.
Department of Anesthesia, Harvard Medical School, Boston, MA, 02115, USA.
Department of Pediatrics, Boston Children's Hospital and Harvard Medical School, Boston, MA, 02115, USA.
ORCID: 0000-0002-3084-3071

Surender Khurana (S)

Division of Viral Products, Center for Biologics Evaluation and Research (CBER), FDA, Silver Spring, MD, 20993, USA. Surender.Khurana@fda.hhs.gov.
ORCID: 0000-0002-0593-7965

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adolescent › Cross-reactive immunity against the SARS-CoV-2...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Anticorps › Anticorps antiviraux › Cross-reactive immunity against the SARS-CoV-2...
questionsmedicales.fr › Maladies de l'appareil respiratoire › Infections de l'appareil respiratoire › Pneumopathie infectieuse › Pneumopathie virale › COVID-19 › Cross-reactive immunity against the SARS-CoV-2...
questionsmedicales.fr › Personnes › Tranches d'âge › Enfant › Cross-reactive immunity against the SARS-CoV-2...
questionsmedicales.fr › Personnes › Tranches d'âge › Enfant › Enfant d'âge préscolaire › Cross-reactive immunity against the SARS-CoV-2...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Cross-reactive immunity against the SARS-CoV-2...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Glycoprotéines membranaires › Cross-reactive immunity against the SARS-CoV-2...
questionsmedicales.fr › Techniques d'investigation › Techniques immunologiques › Tests immunologiques › Tests sérologiques › Tests de neutralisation › Cross-reactive immunity against the SARS-CoV-2...
questionsmedicales.fr › Virus › Virus à ARN › Virus à ARN à brin positif › Nidovirales › Coronaviridae › Coronavirus › Betacoronavirus › Virus du SRAS › SARS-CoV-2 › Cross-reactive immunity against the SARS-CoV-2...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines virales › Protéines virales structurales › Protéines de l'enveloppe virale › Protéines de fusion virale › Glycoprotéine de spicule des coronavirus › Cross-reactive immunity against the SARS-CoV-2...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Choc › Syndrome de réponse inflammatoire généralisée › Cross-reactive immunity against the SARS-CoV-2...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines virales › Protéines virales structurales › Protéines de l'enveloppe virale › Cross-reactive immunity against the SARS-CoV-2...