Modulation of Apoptosis and Cell Death Pathways by Varicella-Zoster Virus.

Apoptosis Programmed cell death Varicella-zoster virus

Journal

Current topics in microbiology and immunology
ISSN: 0070-217X
Titre abrégé: Curr Top Microbiol Immunol
Pays: Germany
ID NLM: 0110513

Informations de publication

Date de publication:
2023
Historique:
pubmed: 28 5 2022
medline: 4 11 2022
entrez: 27 5 2022
Statut: ppublish

Résumé

Like other herpesviruses, varicella-zoster virus (VZV) evolved a wide range of functions to modulate a broad array of host defences, presumably as a means to provide a survival advantage to the virus during infection. In addition to control of components of the adaptive immune response, VZV also modulates a range of innate responses. In this context, it has become increasingly apparent that VZV encodes specific functions that interfere with programmed cell death (PCD) pathways. This review will overview the current understanding of VZV-mediated control of PCD pathways, focussing on the three most well-defined PCD pathways: apoptosis, necroptosis and pyroptosis. We will also discuss future directions about these PCD pathways that are yet to be explored in the context of VZV infection.

Identifiants

pubmed: 35624346
doi: 10.1007/82_2021_249
doi:

Types de publication

Review Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

59-73

Informations de copyright

© 2021. The Author(s), under exclusive license to Springer Nature Switzerland AG.

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Auteurs

Megan Steain (M)

Infection, Immunity and Inflammation, School of Medical Sciences, Faculty of Medicine and Health, Charles Perkins Centre, University of Sydney, Level 5 (East) D17, Sydney, NSW, 2006, Australia.
Sydney Institute for Infectious Diseases, University of Sydney, Sydney, Australia.

Barry Slobedman (B)

Infection, Immunity and Inflammation, School of Medical Sciences, Faculty of Medicine and Health, Charles Perkins Centre, University of Sydney, Level 5 (East) D17, Sydney, NSW, 2006, Australia.
Sydney Institute for Infectious Diseases, University of Sydney, Sydney, Australia.

Allison Abendroth (A)

Infection, Immunity and Inflammation, School of Medical Sciences, Faculty of Medicine and Health, Charles Perkins Centre, University of Sydney, Level 5 (East) D17, Sydney, NSW, 2006, Australia. allison.abendroth@sydney.edu.au.
Sydney Institute for Infectious Diseases, University of Sydney, Sydney, Australia. allison.abendroth@sydney.edu.au.

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Classifications MeSH