Group B Streptococcal Hemolytic Pigment Impairs Platelet Function in a Two-Step Process.
Streptococcus agalactiae
group B streptococcus
pigment
platelets
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
13 05 2022
13 05 2022
Historique:
received:
22
02
2022
revised:
10
05
2022
accepted:
10
05
2022
entrez:
28
5
2022
pubmed:
29
5
2022
medline:
1
6
2022
Statut:
epublish
Résumé
Group B streptococci (GBS) cause a range of invasive maternal-fetal diseases during pregnancy and post-partum. However, invasive infections in non-pregnant adults are constantly increasing. These include sepsis and streptococcal toxic shock syndrome, which are often complicated by systemic coagulation and thrombocytopenia. GBS express a hyper-hemolytic ornithine rhamnolipid pigment toxin with cytolytic and coagulatory activity. Here, we investigated the effects of GBS pigment on human platelets. Infections of platelets with pigmented GBS resulted initially in platelet activation, followed by necrotic cell death. Thus, this study shows that GBS pigment kills human platelets.
Identifiants
pubmed: 35626674
pii: cells11101637
doi: 10.3390/cells11101637
pmc: PMC9139542
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIAID NIH HHS
ID : R01 AI112619
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI145890
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI152268
Pays : United States
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