Interaction of Arginine-Rich Cell-Penetrating Peptides with an Artificial Neuronal Membrane.
PTD4 peptide
Tat(49–57)-NH2
artificial neuronal membrane
cell-penetrating peptides
circular dichroism studies
liposome
molecular dynamics simulations
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
13 05 2022
13 05 2022
Historique:
received:
29
03
2022
revised:
10
05
2022
accepted:
11
05
2022
entrez:
28
5
2022
pubmed:
29
5
2022
medline:
1
6
2022
Statut:
epublish
Résumé
Arginine-rich cell-penetrating peptides (RRCPPs) exhibit intrinsic neuroprotective effects on neurons injured by acute ischemic stroke. Conformational properties, interaction, and the ability to penetrate the neural membrane are critical for the neuroprotective effects of RRCCPs. In this study, we applied circular dichroism (CD) spectroscopy and coarse-grained molecular dynamics (CG MD) simulations to investigate the interactions of two RRCPPs, Tat(49-57)-NH
Identifiants
pubmed: 35626677
pii: cells11101638
doi: 10.3390/cells11101638
pmc: PMC9139471
pii:
doi:
Substances chimiques
Cell-Penetrating Peptides
0
Gene Products, tat
0
Liposomes
0
Membranes, Artificial
0
Neuroprotective Agents
0
Arginine
94ZLA3W45F
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Références
Folia Histochem Cytobiol. 2014;52(4):257-69
pubmed: 25530464
Neurotox Res. 2009 Feb;15(2):123-6
pubmed: 19384574
ACS Chem Neurosci. 2020 Jul 1;11(13):1965-1977
pubmed: 32492332
Protein Pept Lett. 2014 Jul;21(7):672-8
pubmed: 24654853
Arch Biochem Biophys. 2019 Jan;661:74-86
pubmed: 30447207
J Pept Sci. 2004 Jul;10(7):423-6
pubmed: 15298177
J Pharmacol Exp Ther. 2015 Jul;354(1):32-42
pubmed: 25922342
Sci Rep. 2019 Feb 4;9(1):1349
pubmed: 30718681
Bioconjug Chem. 2019 Mar 20;30(3):760-774
pubmed: 30653302
J Cereb Blood Flow Metab. 2015 Jun;35(6):993-1004
pubmed: 25669902
J Chem Theory Comput. 2008 Mar;4(3):435-47
pubmed: 26620784
Membranes (Basel). 2021 Dec 09;11(12):
pubmed: 34940475
J Phys Chem B. 2010 Feb 4;114(4):1652-60
pubmed: 20055378
J Chromatogr A. 2002 Aug 30;968(1-2):211-20
pubmed: 12236505
Biochemistry. 1999 Aug 3;38(31):10059-69
pubmed: 10433713
Methods Mol Biol. 2013;924:533-65
pubmed: 23034762
J Mol Biol. 1995 Oct 20;253(2):313-32
pubmed: 7563092
JAMA. 2021 Mar 16;325(11):1088-1098
pubmed: 33724327
J Chem Theory Comput. 2016 Jan 12;12(1):405-13
pubmed: 26631602
J Comput Chem. 2009 Jul 30;30(10):1545-614
pubmed: 19444816
J Comput Chem. 2008 Aug;29(11):1859-65
pubmed: 18351591
Int J Mol Sci. 2021 Jun 04;22(11):
pubmed: 34200045
ACS Chem Neurosci. 2021 Jul 7;12(13):2491-2502
pubmed: 34133880
Biopolymers. 2003 Jun;69(2):270-81
pubmed: 12767128
Cancer Res. 2001 Jan 15;61(2):474-7
pubmed: 11212234
Pharmacol Ther. 2015 Sep;153:36-54
pubmed: 26048328
N Engl J Med. 1995 Dec 14;333(24):1581-7
pubmed: 7477192
Chemphyschem. 2021 Mar 3;22(5):493-498
pubmed: 33377300
Phys Chem Chem Phys. 2009 Mar 28;11(12):1934-41
pubmed: 19280004
Proc Natl Acad Sci U S A. 2021 Sep 28;118(39):
pubmed: 34544868
Front Neurol. 2020 Feb 25;11:108
pubmed: 32158425
Mol Neurodegener. 2011 Jan 25;6(1):11
pubmed: 21266064
Membranes (Basel). 2022 Jan 13;12(1):
pubmed: 35054614
Pharmaceuticals (Basel). 2010 Mar 30;3(4):961-993
pubmed: 27713284
Cell Mol Neurobiol. 2014 Mar;34(2):173-81
pubmed: 24213248
FEBS Lett. 2017 Mar;591(5):784-791
pubmed: 28186641
Beilstein J Nanotechnol. 2020 Jan 9;11:101-123
pubmed: 31976201
J Comput Chem. 2014 Oct 15;35(27):1997-2004
pubmed: 25130509
Stroke. 2011 Aug;42(8):2351-5
pubmed: 21778445
J Phys Chem B. 2007 Jul 12;111(27):7812-24
pubmed: 17569554
Molecules. 2017 Nov 08;22(11):
pubmed: 29117144
Stroke. 2021 Oct;52(10):e646-e659
pubmed: 34404236