Exosome-Associated circRNAs as Key Regulators of EMT in Cancer.
circular RNAs
epithelial tumor progression
epithelial-to-mesenchymal transition
extracellular vesicles
tumor microenvironment (TME)
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
23 05 2022
23 05 2022
Historique:
received:
10
03
2022
revised:
17
05
2022
accepted:
19
05
2022
entrez:
28
5
2022
pubmed:
29
5
2022
medline:
1
6
2022
Statut:
epublish
Résumé
Epithelial-to-mesenchymal transition (EMT) is a dynamic program of cell plasticity aberrantly reactivated in cancer. The crosstalk between tumor cells and the tumoral microenvironment (TME) has a pivotal importance for the induction of the EMT and the progression toward a malignant phenotype. Notably, exosomes are key mediators of this crosstalk as vehicles of specific molecular signals that include the class of circular RNAs (circRNAs). This review specifically focuses on the role of exosome-associated circRNAs as key regulators of EMT in cancer. The relevance of these molecules in regulating the intercellular communication in TME and tumor progression is highlighted. Moreover, the here-presented evidence indicates that exosome-associated circRNA modulation should be taken in account for cancer diagnostic and therapeutic approaches.
Identifiants
pubmed: 35626752
pii: cells11101716
doi: 10.3390/cells11101716
pmc: PMC9140110
pii:
doi:
Substances chimiques
RNA, Circular
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
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