Role of Mitochondrial Dynamics in Cocaine's Neurotoxicity.
Drp1
cocaine
endoplasmic reticulum
mitochondrial dynamics
mitochondrial fission
mitochondrial fusion
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
12 May 2022
12 May 2022
Historique:
received:
20
04
2022
revised:
10
05
2022
accepted:
10
05
2022
entrez:
28
5
2022
pubmed:
29
5
2022
medline:
1
6
2022
Statut:
epublish
Résumé
The dynamic balance of mitochondrial fission and fusion maintains mitochondrial homeostasis and optimal function. It is indispensable for cells such as neurons, which rely on the finely tuned mitochondria to carry out their normal physiological activities. The potent psychostimulant cocaine impairs mitochondria as one way it exerts its neurotoxicity, wherein the disturbances in mitochondrial dynamics have been suggested to play an essential role. In this review, we summarize the neurotoxicity of cocaine and the role of mitochondrial dynamics in cellular physiology. Subsequently, we introduce current findings that link disturbed neuronal mitochondrial dynamics with cocaine exposure. Finally, the possible role and potential therapeutic value of mitochondrial dynamics in cocaine neurotoxicity are discussed.
Identifiants
pubmed: 35628228
pii: ijms23105418
doi: 10.3390/ijms23105418
pmc: PMC9145816
pii:
doi:
Substances chimiques
Cocaine
I5Y540LHVR
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : MEXT KAKENHI
ID : 20H03955
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