The Role of DNA Repair in Genomic Instability of Multiple Myeloma.
DNA damage response
DNA repair
genomic instability
multiple myeloma
myeloma therapeutics
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
19 May 2022
19 May 2022
Historique:
received:
12
04
2022
revised:
15
05
2022
accepted:
16
05
2022
entrez:
28
5
2022
pubmed:
29
5
2022
medline:
1
6
2022
Statut:
epublish
Résumé
Multiple Myeloma (MM) is a B cell malignancy marked by genomic instability that arises both through pathogenesis and during disease progression. Despite recent advances in therapy, MM remains incurable. Recently, it has been reported that DNA repair can influence genomic changes and drug resistance in MM. The dysregulation of DNA repair function may provide an alternative explanation for genomic instability observed in MM cells and in cells derived from MM patients. This review provides an overview of DNA repair pathways with a special focus on their involvement in MM and discusses the role they play in MM progression and drug resistance. This review highlights how unrepaired DNA damage due to aberrant DNA repair response in MM exacerbates genomic instability and chromosomal abnormalities, enabling MM progression and drug resistance.
Identifiants
pubmed: 35628498
pii: ijms23105688
doi: 10.3390/ijms23105688
pmc: PMC9144728
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : CIHR
ID : grant number 154485
Pays : Canada
Organisme : Natural Sciences and Engineering Research Council
ID : RGPIN-2017-05752
Organisme : Cancer Research Society
ID : grant number 22019,
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