Role of Dipeptidyl Peptidase 4 Inhibitors in Antidiabetic Treatment.
DPP4i
GIP
GLP1
T2DM
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
10 May 2022
10 May 2022
Historique:
received:
31
03
2022
revised:
02
05
2022
accepted:
07
05
2022
entrez:
28
5
2022
pubmed:
29
5
2022
medline:
1
6
2022
Statut:
epublish
Résumé
In recent years, important changes have occurred in the field of diabetes treatment. The focus of the treatment of diabetic patients has shifted from the control of blood glucose itself to the overall management of risk factors, while adjusting blood glucose goals according to individualization. In addition, regulators need to approve new antidiabetic drugs which have been tested for cardiovascular safety. Thus, the newest class of drugs has been shown to reduce major adverse cardiovascular events, including sodium-glucose transporter 2 (SGLT2) and some glucagon like peptide 1 receptor (GLP1) analog. As such, they have a prominent place in the hyperglycemia treatment algorithms. In recent years, the role of DPP4 inhibitors (DPP4i) has been modified. DPP4i have a favorable safety profile and anti-inflammatory profile, do not cause hypoglycemia or weight gain, and do not require dose escalation. In addition, it can also be applied to some types of chronic kidney disease patients and elderly patients with diabetes. Overall, DPP4i, as a class of safe oral hypoglycemic agents, have a role in the management of diabetic patients, and there is extensive experience in their use.
Identifiants
pubmed: 35630534
pii: molecules27103055
doi: 10.3390/molecules27103055
pmc: PMC9147686
pii:
doi:
Substances chimiques
Blood Glucose
0
Dipeptidyl-Peptidase IV Inhibitors
0
Hypoglycemic Agents
0
Sodium-Glucose Transporter 2
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Références
BMC Pharmacol Toxicol. 2020 Sep 16;21(1):68
pubmed: 32938499
Biochim Biophys Acta. 2014 Sep;1842(9):1613-21
pubmed: 24928308
J Clin Pharmacol. 2007 May;47(5):633-41
pubmed: 17442688
Clin Pharmacokinet. 2017 Jan;56(1):11-24
pubmed: 27282159
Diabetes Obes Metab. 2010 Aug;12(8):648-58
pubmed: 20590741
Expert Opin Drug Saf. 2018 Aug;17(8):815-824
pubmed: 29975558
Lancet Diabetes Endocrinol. 2018 Jan;6(1):69-80
pubmed: 28847479
Clin Pharmacokinet. 2012 Jul 1;51(7):411-27
pubmed: 22568694
Diabetes Care. 2019 Oct;42(10):1930-1938
pubmed: 31399442
J Endocrinol. 2009 Jan;200(1):53-61
pubmed: 18931022
Nutr Metab Cardiovasc Dis. 2021 Sep 22;31(10):2745-2755
pubmed: 34364771
Cell Metab. 2019 Feb 5;29(2):320-334.e5
pubmed: 30393019
J Mol Endocrinol. 2012 Aug 30;49(2):125-35
pubmed: 22822047
Curr Top Med Chem. 2007;7(6):557-68
pubmed: 17352677
J Cell Physiol. 2021 Dec;236(12):8060-8069
pubmed: 34192347
Curr Med Sci. 2022 Jun;42(3):513-519
pubmed: 35451807
J Diabetes Metab Disord. 2015 Mar 19;14:15
pubmed: 26473146
Toxicol Appl Pharmacol. 2020 Nov 15;407:115246
pubmed: 32956689
Minerva Med. 2021 Aug;112(4):522-524
pubmed: 31726811
Int Immunopharmacol. 2020 Oct;87:106774
pubmed: 32731178
Atherosclerosis. 2020 Jul;305:64-72
pubmed: 32386751
Diabetes Obes Metab. 2015 Jan;17(1):74-81
pubmed: 25243647
Diabetes Obes Metab. 2011 Jul;13(7):594-603
pubmed: 21320267
Diabetologia. 2009 Feb;52(2):199-207
pubmed: 19037628
Neurosci Bull. 2020 Apr;36(4):407-418
pubmed: 31808042
Biochim Biophys Acta Mol Basis Dis. 2020 Jun 1;1866(6):165741
pubmed: 32101757
Nephron. 2017;136(2):85-94
pubmed: 28178698
Biochem Biophys Res Commun. 2013 May 3;434(2):191-6
pubmed: 23501107
Diabetes. 1998 Nov;47(11):1663-70
pubmed: 9792533
Diabetes Care. 2007 Jun;30(6):1344-50
pubmed: 17337494
Cell Tissue Res. 2022 May;388(2):417-438
pubmed: 35107620
Cell Death Dis. 2021 Oct 11;12(10):928
pubmed: 34635643
Diabetes Metab Syndr Obes. 2020 Dec 15;13:4993-5001
pubmed: 33364803
Expert Opin Drug Saf. 2018 Apr;17(4):387-405
pubmed: 29468916
Clin Ther. 2016 Mar;38(3):516-30
pubmed: 26869191
Endocrine. 2016 Jun;52(3):458-80
pubmed: 26714458
Int J Mol Sci. 2021 Oct 17;22(20):
pubmed: 34681847
Int Immunopharmacol. 2021 Mar;92:107354
pubmed: 33434756
J Med Chem. 2005 Jul 28;48(15):5025-37
pubmed: 16033281
Medicine (Baltimore). 2022 Feb 25;101(8):e28823
pubmed: 35212277
Front Immunol. 2015 Jul 27;6:386
pubmed: 26284071
Drugs. 2017 Feb;77(2):209-224
pubmed: 28078647
Int J Mol Sci. 2020 Oct 22;21(21):
pubmed: 33105604
Diabetes Obes Metab. 2009 Apr;11(4):285-92
pubmed: 19175376
Atherosclerosis. 2015 Oct;242(2):580-8
pubmed: 26318108
Endocrine. 2016 Mar;51(3):429-39
pubmed: 26349938
Nat Rev Drug Discov. 2022 Mar;21(3):201-223
pubmed: 34815532
Diabetes Obes Metab. 2012 Oct;14(10):927-36
pubmed: 22583697
Regul Pept. 1999 Nov 30;85(1):9-24
pubmed: 10588446
J Inflamm Res. 2021 Nov 02;14:5681-5686
pubmed: 34754214
Curr Med Res Opin. 2011 Sep;27(9):1781-92
pubmed: 21806314
Nat Rev Endocrinol. 2020 Jun;16(6):321-331
pubmed: 32203408
Molecules. 2022 Jan 22;27(3):
pubmed: 35163991
Diabetes. 2013 Jan;62(1):149-57
pubmed: 22936179
Diabetes Obes Metab. 2011 Oct;13(10):939-46
pubmed: 21672124
Diabetes Metab Res Rev. 2010 Oct;26(7):540-9
pubmed: 20824678
J Chromatogr B Analyt Technol Biomed Life Sci. 2021 Dec 1;1186:122990
pubmed: 34735973
Am J Physiol Endocrinol Metab. 2011 Feb;300(2):E372-9
pubmed: 21139073
Br J Clin Pharmacol. 2012 Jul;74(1):75-85
pubmed: 22242621
Diabetes Metab J. 2022 Sep;46(5):689-700
pubmed: 35295073
Biopharm Drug Dispos. 2007 Sep;28(6):315-22
pubmed: 17575559
Int J Mol Sci. 2022 Mar 12;23(6):
pubmed: 35328486
Nature. 2018 Mar 29;555(7698):673-677
pubmed: 29562231
Diabetes Obes Metab. 2020 Jun;22(6):1001-1005
pubmed: 32020696
JCI Insight. 2018 Dec 6;3(23):
pubmed: 30518693
Mol Ther. 2021 Jan 6;29(1):365-375
pubmed: 32956626
Nature. 2013 Mar 14;495(7440):251-4
pubmed: 23486063
Bioengineered. 2022 Jan;13(1):655-666
pubmed: 34967261
Diabetes Obes Metab. 2011 Jan;13(1):7-18
pubmed: 21114598
Psychosom Med. 2021 Oct 1;83(8):913-923
pubmed: 34292203
Clin Exp Immunol. 2016 Jul;185(1):1-21
pubmed: 26919392
Am J Clin Dermatol. 2021 Nov;22(6):891-900
pubmed: 34287770
Biochem Pharmacol. 2020 Jul;177:113951
pubmed: 32251672
Bioorg Med Chem Lett. 2007 Jan 1;17(1):49-52
pubmed: 17055272
Mini Rev Med Chem. 2010 Jul;10(8):759-65
pubmed: 20402634
Eur J Pharmacol. 2021 Dec 5;912:174602
pubmed: 34710367
Int J Neuropsychopharmacol. 2021 Feb 15;24(2):158-169
pubmed: 33125461
Diabetologia. 2013 Apr;56(4):696-708
pubmed: 23344728
Diabetes Obes Metab. 2018 Jan;20(1):195-199
pubmed: 28640433
Diabetes Ther. 2013 Dec;4(2):431-42
pubmed: 24163113
Clin Ther. 2008 Mar;30(3):513-27
pubmed: 18405789
Diabetes Care. 2017 Apr;40(4):494-501
pubmed: 28057693
Diabetes Care. 2013 Nov;36(11):3460-8
pubmed: 24026560
Dan Med J. 2016 Apr;63(4):
pubmed: 27034187
J Diabetes Res. 2021 Oct 16;2021:7382620
pubmed: 34697593
Life Sci. 2021 May 15;273:119295
pubmed: 33667522
J Diabetes Metab Disord. 2016 Aug 30;15(1):34
pubmed: 27583244
Antioxidants (Basel). 2021 Sep 29;10(10):
pubmed: 34679685
Diabetes Care. 2015 Jun;38(6):1145-53
pubmed: 25758769
Front Oncol. 2021 Sep 24;11:728047
pubmed: 34631556
Nat Rev Drug Discov. 2011 Aug 01;10(8):579-90
pubmed: 21804595
JAMA. 2019 Jan 1;321(1):69-79
pubmed: 30418475
Front Pharmacol. 2021 Aug 31;12:670389
pubmed: 34531738
Am J Physiol Renal Physiol. 2021 Mar 1;320(3):F505-F517
pubmed: 33522410
Nat Rev Endocrinol. 2011 Nov 08;8(4):228-36
pubmed: 22064493
Diabetes Obes Metab. 2014 Sep;16(9):812-8
pubmed: 24612221
Am J Transplant. 2022 Jun;22(6):1537-1549
pubmed: 35294797
Biochimie. 2020 Jan;168:198-209
pubmed: 31715215
Diabetes Metab Syndr Obes. 2021 Mar 09;14:1095-1105
pubmed: 33727843
Diabetes Ther. 2018 Feb;9(1):309-315
pubmed: 29330813
Diabetes Obes Metab. 2021 Jan;23(1):68-74
pubmed: 32886401
Biology (Basel). 2022 Feb 11;11(2):
pubmed: 35205155
Mini Rev Med Chem. 2019;19(2):88-97
pubmed: 29692250
Curr Drug Targets. 2018;19(15):1738-1766
pubmed: 30051787
J Clin Endocrinol Metab. 2009 Apr;94(4):1236-43
pubmed: 19174497
Front Endocrinol (Lausanne). 2019 Jun 19;10:376
pubmed: 31275243
Drugs Today (Barc). 2011 Feb;47(2):99-107
pubmed: 21431099
Commun Biol. 2021 Jan 29;4(1):144
pubmed: 33514826
Clin Pharmacokinet. 2012 Mar 1;51(3):147-62
pubmed: 22339447
Diabetologia. 2002 Aug;45(8):1111-9
pubmed: 12189441
J Endocrinol Invest. 2016 Sep;39(9):1061-74
pubmed: 27072669
Diabetes. 2011 Apr;60(4):1270-6
pubmed: 21330636
Arch Physiol Biochem. 2021 Sep 20;:1-9
pubmed: 34543583
Cardiol Rev. 2007 Sep-Oct;15(5):264-71
pubmed: 17700385
Int J Mol Sci. 2020 Apr 23;21(8):
pubmed: 32340263
Front Pharmacol. 2021 Dec 07;12:779652
pubmed: 34950037
Diabetes Obes Metab. 2017 Mar;19(3):429-435
pubmed: 27943546
Diabetes Obes Metab. 2016 Nov;18(11):1100-1109
pubmed: 27300579
Nat Rev Drug Discov. 2017 Dec;16(12):829-842
pubmed: 29075003
Br J Pharmacol. 2021 Feb;178(4):878-895
pubmed: 33171531
Am J Transl Res. 2019 Apr 15;11(4):2099-2107
pubmed: 31105821
Bioengineered. 2022 Jan;13(1):800-809
pubmed: 34964708
Diabetes. 1998 May;47(5):764-9
pubmed: 9588448
J Med Chem. 2003 Jun 19;46(13):2774-89
pubmed: 12801240
Cardiovasc Diabetol. 2012 Jan 10;11:3
pubmed: 22234149
Diabetes Obes Metab. 2021 Feb;23(2):642-647
pubmed: 33074590
Clin Pharmacokinet. 2011 Apr;50(4):253-65
pubmed: 21348538
Drug Des Devel Ther. 2020 Sep 25;14:3929-3940
pubmed: 33061298
Sci Rep. 2022 Mar 24;12(1):5129
pubmed: 35332212
Diabetes Obes Metab. 2012 Apr;14(4):383-4
pubmed: 22390829
Diabetes. 2014 Mar;63(3):1079-92
pubmed: 24296715
Chem Biol Interact. 2020 Jan 5;315:108864
pubmed: 31629700
Cardiol Rev. 2012 Jan-Feb;20(1):45-51
pubmed: 22143285
Front Endocrinol (Lausanne). 2015 Apr 24;6:55
pubmed: 25964776
Oxid Med Cell Longev. 2020 Jul 25;2020:8308616
pubmed: 32774687
J Diabetes. 2015 May;7(3):347-59
pubmed: 25043156
Eur J Pharmacol. 2020 Aug 15;881:173224
pubmed: 32454118
Diabet Med. 2018 Jun;35(6):737-744
pubmed: 29460341
Endocr Rev. 2014 Dec;35(6):992-1019
pubmed: 25216328
Antioxidants (Basel). 2021 Jul 22;10(8):
pubmed: 34439416
Diabetes Obes Metab. 2020 Apr;22(4):590-598
pubmed: 31789451
Diabetes. 2016 Aug;65(8):2440-7
pubmed: 27207543
Int Immunopharmacol. 2020 Jun;83:106372
pubmed: 32179246
Drug Chem Toxicol. 2022 May;45(3):1254-1263
pubmed: 32869669
Toxicol Appl Pharmacol. 2022 Mar 1;438:115906
pubmed: 35122774
Nat Rev Endocrinol. 2020 Nov;16(11):642-653
pubmed: 32929230
J Am Coll Cardiol. 2019 Sep 10;74(10):1376-1414
pubmed: 30894319