Design, Cytotoxicity and Antiproliferative Activity of 4-Amino-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylates against MFC-7 and MDA-MB-231 Breast Cancer Cell Lines.
4-amino-thienopyrimidines
antiproliferation
cytotoxicity
molecular structure
phototoxicity
structure–activity relationship
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
21 May 2022
21 May 2022
Historique:
received:
14
04
2022
revised:
13
05
2022
accepted:
18
05
2022
entrez:
28
5
2022
pubmed:
29
5
2022
medline:
1
6
2022
Statut:
epublish
Résumé
Novel 4-amino-thieno[2,3-d]pyrimidine-6-carboxylates substituted at the second position were prepared by cyclocondensation of 2-amino-3-cyano-thiophene and aryl nitriles in an acidic medium. The design of the target compounds was based on structural optimization. The derivatives thus obtained were tested in vitro against human and mouse cell lines. The examination of the compound effects on BLAB 3T3 and MFC-10A cells showed that they are safe, making them suitable for subsequent experiments to establish their antitumor activity. The photoirritancy factor of the compounds was calculated. Using the MTT test, the antiproliferative activity to MCF-10A, MCF-7 and MDA-MB-231 cell lines was estimated. The best antiproliferative effect in respect to the MCF-7 cell line revealed compound 2 with IC
Identifiants
pubmed: 35630793
pii: molecules27103314
doi: 10.3390/molecules27103314
pmc: PMC9148072
pii:
doi:
Substances chimiques
Antineoplastic Agents
0
Carboxylic Acids
0
Ligands
0
Pyrimidines
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Bulgarian Science Fund
ID : KP-06-COST/10 (2020) to B.N
Organisme : Bulgarian Ministry of Education and Science
ID : "National Center for Biomedical Photonics" (D01-392/2020) and Scientific Infrastructure on Cell Technologies in Biomedicine (SICTB) (DO1-154/28/08/2018
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