Imaging the fetal nonhuman primate brain with SV2A positron emission tomography (PET).

Animals Brain / diagnostic imaging Macaca mulatta / metabolism Membrane Glycoproteins / metabolism Nerve Tissue Proteins / metabolism Positron-Emission Tomography / methods
In utero Nonhuman primate Positron emission tomography SV2A Synaptogenesis

Journal

European journal of nuclear medicine and molecular imaging
ISSN: 1619-7089
Titre abrégé: Eur J Nucl Med Mol Imaging
Pays: Germany
ID NLM: 101140988

Informations de publication

Date de publication:
09 2022
Historique:
received: 20 12 2021
accepted: 26 04 2022
pubmed: 29 5 2022
medline: 26 8 2022
entrez: 28 5 2022
Statut: ppublish

Résumé

Exploring synaptic density changes during brain growth is crucial to understanding brain development. Previous studies in nonhuman primates report a rapid increase in synapse number between the late gestational period and the early neonatal period, such that synaptic density approaches adult levels by birth. Prenatal synaptic development may have an enduring impact on postnatal brain development, but precisely how synaptic density changes in utero are unknown because current methods to quantify synaptic density are invasive and require post-mortem brain tissue. We used synaptic vesicle glycoprotein 2A (SV2A) positron emission tomography (PET) radioligands [ Image-derived fetal brain SV2A measures increased during the third trimester. SV2A concentrations were greater in subcortical regions than in cortical regions at both gestational ages. Near term, SV2A density was higher in primary motor and visual areas than respective associative regions. Post-mortem quantification of SV2A density was significantly correlated with regional SV2A PET measures. While further study is needed to determine the exact relationship of SV2A and synaptic density, the imaging paradigm developed in the current study allows for the effective in vivo study of SV2A development in the fetal brain.

Identifiants

DOI: 10.1007/s00259-022-05825-6 PMID: 35633376 PMC: PMC9826644
pubmed: 35633376
doi: 10.1007/s00259-022-05825-6
pii: 10.1007/s00259-022-05825-6
pmc: PMC9826644
mid: NIHMS1845163
doi:

Substances chimiques

Membrane Glycoproteins 0
Nerve Tissue Proteins 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

3679-3691

Subventions

Organisme : NIH HHS
ID : S10 OD016261
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001863
Pays : United States
Organisme : NIH HHS
ID : P51 OD011107
Pays : United States
Organisme : NIMH NIH HHS
ID : R21 MH120615
Pays : United States
Organisme : NCRR NIH HHS
ID : S10 RR025063
Pays : United States
Organisme : NHLBI NIH HHS
ID : R24 HL085794
Pays : United States
Organisme : NCRR NIH HHS
ID : S10 RR029245
Pays : United States
Organisme : NIH HHS
ID : U42 OD027094
Pays : United States

Informations de copyright

© 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.

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Auteurs

Samantha Rossano (S)

Department of Radiology and Biomedical Imaging, Yale PET Center, Yale School of Medicine, New Haven, CT, USA. samantha.rossano@yale.edu.
Department of Biomedical Engineering, Yale University, New Haven, CT, USA. samantha.rossano@yale.edu.
ORCID: 0000-0003-0986-9100

Takuya Toyonaga (T)

Department of Radiology and Biomedical Imaging, Yale PET Center, Yale School of Medicine, New Haven, CT, USA.

Eric Berg (E)

Department of Biomedical Engineering, University of California, Davis, CA, USA.

Isabella Lorence (I)

Department of Radiology and Biomedical Imaging, Yale PET Center, Yale School of Medicine, New Haven, CT, USA.

Krista Fowles (K)

Department of Radiology and Biomedical Imaging, Yale PET Center, Yale School of Medicine, New Haven, CT, USA.

Nabeel Nabulsi (N)

Department of Radiology and Biomedical Imaging, Yale PET Center, Yale School of Medicine, New Haven, CT, USA.

Jim Ropchan (J)

Department of Radiology and Biomedical Imaging, Yale PET Center, Yale School of Medicine, New Haven, CT, USA.

Songye Li (S)

Department of Radiology and Biomedical Imaging, Yale PET Center, Yale School of Medicine, New Haven, CT, USA.

Yunpeng Ye (Y)

Department of Radiology and Biomedical Imaging, Yale PET Center, Yale School of Medicine, New Haven, CT, USA.

Zachary Felchner (Z)

Department of Radiology and Biomedical Imaging, Yale PET Center, Yale School of Medicine, New Haven, CT, USA.

David Kukis (D)

Center for Molecular and Genomic Imaging, University of California, Davis, CA, USA.

Yiyun Huang (Y)

Department of Radiology and Biomedical Imaging, Yale PET Center, Yale School of Medicine, New Haven, CT, USA.

Helene Benveniste (H)

Department of Anesthesiology, Yale School of Medicine, Yale University, New Haven, CT, USA.

Alice F Tarantal (AF)

Departments of Pediatrics and Cell Biology and Human Anatomy, School of Medicine, and California National Primate Research Center, University of California, Davis, CA, USA.

Stephanie Groman (S)

Department of Psychiatry, Yale University, New Haven, CT, USA.
Department of Neuroscience, University of Minnesota, Minneapolis, MN, USA.

Richard E Carson (RE)

Department of Radiology and Biomedical Imaging, Yale PET Center, Yale School of Medicine, New Haven, CT, USA.
Department of Biomedical Engineering, Yale University, New Haven, CT, USA.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Imaging the fetal nonhuman primate brain with...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Imaging the fetal nonhuman primate brain with...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Cercopithecidae › Cercopithecinae › Macaca › Macaca mulatta › Imaging the fetal nonhuman primate brain with...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Glycoprotéines membranaires › Imaging the fetal nonhuman primate brain with...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de tissu nerveux › Imaging the fetal nonhuman primate brain with...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Techniques de diagnostic radioisotopique › Scintigraphie › Tomoscintigraphie › Tomographie par émission de positons › Imaging the fetal nonhuman primate brain with...