Pemphigus Foliaceus Autoantibodies Induce Redistribution Primarily of Extradesmosomal Desmoglein 1 in the Cell Membrane.
Stimulated Emission Depletion (STED)
desmoglein (Dsg)
localization
pemphigus
signaling / signaling pathways
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2022
2022
Historique:
received:
23
02
2022
accepted:
20
04
2022
entrez:
31
5
2022
pubmed:
1
6
2022
medline:
3
6
2022
Statut:
epublish
Résumé
The autoimmune dermatosis pemphigus foliaceus (PF) is predominantly caused by IgG autoantibodies against the desmosomal cadherin desmoglein (Dsg) 1. The exact mechanisms that lead to the characteristic epidermal blistering are not yet fully understood. In the present study, we used a variety of biophysical methods to examine the fate of membrane-bound Dsg1 after incubation with PF patients' IgG. Dispase-based dissociation assays confirmed that PF-IgG used for this study reduced intercellular adhesion in a manner dependent on phospholipase C (PLC)/Ca
Identifiants
pubmed: 35634274
doi: 10.3389/fimmu.2022.882116
pmc: PMC9134081
doi:
Substances chimiques
Autoantibodies
0
Desmoglein 1
0
Immunoglobulin G
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
882116Informations de copyright
Copyright © 2022 Hiermaier, Kugelmann, Radeva, Didona, Ghoreschi, Farzan, Hertl and Waschke.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Nature. 1970 Aug 15;227(5259):680-5
pubmed: 5432063
Cold Spring Harb Perspect Biol. 2009 Aug;1(2):a002543
pubmed: 20066089
J Invest Dermatol. 2018 Jan;138(1):32-37
pubmed: 29037765
J Invest Dermatol. 2021 May;141(5):1219-1229.e11
pubmed: 33098828
J Cell Biol. 2006 Dec 4;175(5):721-7
pubmed: 17130286
J Clin Invest. 2005 Nov;115(11):3157-65
pubmed: 16211092
J Cell Biol. 2020 Jun 1;219(6):
pubmed: 32399559
Bioconjug Chem. 2007 Jul-Aug;18(4):1176-84
pubmed: 17516625
J Invest Dermatol. 2018 Jan;138(1):121-131
pubmed: 28899688
Trends Cell Biol. 2013 Nov;23(11):537-46
pubmed: 23891292
J Cell Biol. 1988 Mar;106(3):761-71
pubmed: 2450098
Front Med (Lausanne). 2018 Aug 14;5:226
pubmed: 30155467
J Cell Physiol. 2007 Feb;210(2):411-6
pubmed: 17058228
J Anat. 2022 Feb 6;:
pubmed: 35128661
Cell Commun Adhes. 2014 Dec;21(6):269-80
pubmed: 25078507
Front Med (Lausanne). 2021 Aug 09;8:701809
pubmed: 34434944
Front Physiol. 2020 May 21;11:430
pubmed: 32508670
Br J Dermatol. 2021 Sep;185(3):595-604
pubmed: 33792909
Clin Rev Allergy Immunol. 2018 Feb;54(1):1-25
pubmed: 29313220
Methods Mol Biol. 2011;769:387-402
pubmed: 21748690
Am J Pathol. 2011 Oct;179(4):1905-16
pubmed: 21864491
PLoS One. 2013;8(1):e53739
pubmed: 23326495
J Dtsch Dermatol Ges. 2020 May;18(5):516-526
pubmed: 32413212
J Invest Dermatol. 2005 May;124(5):939-46
pubmed: 15854034
J Clin Invest. 1992 Sep;90(3):919-26
pubmed: 1522242
EMBO J. 2018 Jan 4;37(1):139-159
pubmed: 29146773
Med Res Rev. 2014 Nov;34(6):1127-45
pubmed: 24549583
J Invest Dermatol. 1995 Sep;105(3):329-33
pubmed: 7665907
J Invest Dermatol. 2016 Jan;136(1):59-66
pubmed: 26763424
Sci Rep. 2017 Jun 15;7(1):3579
pubmed: 28620161
J Exp Med. 2003 Jun 2;197(11):1501-10
pubmed: 12771179
Front Immunol. 2018 Jun 04;9:1190
pubmed: 29915578
Br J Pharmacol. 2020 Nov;177(22):5114-5130
pubmed: 32815159
Front Med (Lausanne). 2018 Aug 14;5:218
pubmed: 30155465
Circ Res. 2017 Apr 14;120(8):1305-1317
pubmed: 28289018
J Invest Dermatol. 2019 Jul;139(7):1596-1599.e2
pubmed: 30660666
J Cell Sci. 2002 Apr 15;115(Pt 8):1717-32
pubmed: 11950889
J Biol Chem. 2007 Jun 15;282(24):17866-76
pubmed: 17428808
Front Immunol. 2019 May 24;10:1128
pubmed: 31178865
Biochim Biophys Acta. 2008 Mar;1778(3):572-87
pubmed: 17854763
Front Immunol. 2018 Mar 19;9:528
pubmed: 29616033
Exp Dermatol. 2022 Feb;31(2):154-171
pubmed: 34435386
J Clin Invest. 2022 Feb 1;132(3):
pubmed: 34905516
Front Cell Dev Biol. 2021 Sep 23;9:745670
pubmed: 34631720
Ann Anat. 2022 Apr;241:151904
pubmed: 35131450
Lancet. 2019 Sep 7;394(10201):882-894
pubmed: 31498102
Int J Immunopathol Pharmacol. 2007 Apr-Jun;20(2):355-61
pubmed: 17624248
Nat Rev Dis Primers. 2017 May 11;3:17026
pubmed: 28492232
Exp Dermatol. 2016 Nov;25(11):839-846
pubmed: 27305362
Br J Dermatol. 2017 Dec;177(6):1612-1618
pubmed: 28600798
Cell Commun Adhes. 2014 Feb;21(1):65-75
pubmed: 24460202
J Cell Sci. 2009 Dec 15;122(Pt 24):4401-7
pubmed: 19955337
J Microsc. 1993 Mar;169(3):375-382
pubmed: 33930978