Upregulating Human Cathelicidin Antimicrobial Peptide LL-37 Expression May Prevent Severe COVID-19 Inflammatory Responses and Reduce Microthrombosis.
COVID-19
LL-37
NET clearance
SARS-CoV-2
alpha synuclein
cathelicidin
diabetes
neutrophil extracellular trap (NET)
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2022
2022
Historique:
received:
22
02
2022
accepted:
11
04
2022
entrez:
31
5
2022
pubmed:
1
6
2022
medline:
3
6
2022
Statut:
epublish
Résumé
COVID-19 is characterized by hyperactivation by inflammatory cytokines and recruitment of macrophages, neutrophils, and other immune cells, all hallmarks of a strong inflammatory response that can lead to severe complications and multi-organ damage. Mortality in COVID-19 patients is associated with a high prevalence of neutrophil extracellular trap (NET) formation and microthrombosis that are exacerbated by hyperglycemia, diabetes, and old age. SARS-CoV-2 infection in humans and non-human primates have revealed long-term neurological consequences of COVID-19, possibly concomitant with the formation of Lewy bodies in the brain and invasion of the nervous system
Identifiants
pubmed: 35634307
doi: 10.3389/fimmu.2022.880961
pmc: PMC9134243
doi:
Substances chimiques
Antimicrobial Cationic Peptides
0
Antimicrobial Peptides
0
Peptidyl-Dipeptidase A
EC 3.4.15.1
Cathelicidins
0
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
880961Informations de copyright
Copyright © 2022 Aloul, Nielsen, Defensor, Lin, Fortkort, Shamloo, Cirillo, Gombart and Barron.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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