Sargassum horneri extract containing polyphenol alleviates DNCB-induced atopic dermatitis in NC/Nga mice through restoring skin barrier function.
Animals
Mice
Anti-Inflammatory Agents
/ therapeutic use
Cytokines
/ metabolism
Dermatitis, Atopic
/ chemically induced
Dinitrobenzenes
/ adverse effects
Immunoglobulin G
Interleukin-13
/ metabolism
Keratins
/ metabolism
Plant Extracts
/ pharmacology
Polyphenols
/ pharmacology
Sargassum
/ chemistry
Skin
/ metabolism
Skin Diseases
/ chemically induced
Journal
Histology and histopathology
ISSN: 1699-5848
Titre abrégé: Histol Histopathol
Pays: Spain
ID NLM: 8609357
Informations de publication
Date de publication:
Sep 2022
Sep 2022
Historique:
pubmed:
1
6
2022
medline:
26
10
2022
entrez:
31
5
2022
Statut:
ppublish
Résumé
Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by skin barrier dysfunction. Sargassum horneri (S. horneri) is a brown alga that has been widely used in traditional medicine of eastern Asian countries. Recent studies proved that a brown alga S. horneri has anti-inflammatory activity. In this study, we investigated the effect of S. horneri ethanol extract (SHE) against AD in 2,4-dinitrobenzene (DNCB) induced AD in NC/Nga mice. We observed that SHE treatment decreased the epidermal thickness and epidermal hyperplasia that had been worsened through DNCB application. Moreover, SHE significantly inhibited the proliferation of mast cells and decreased the expression of IL-13 on CD4⁺ cells prompted by elevated thymic stromal lymphopoietin (TSLP) expression in DNCB-induced AD in mice. We also demonstrated that SHE directly inhibited the expression of keratinocyte-produced TSLP known to exacerbate skin barrier impairment. Especially, the decrease of filaggrin, an integral component of proper skin barrier function through a function in aggregating keratin filaments, observed in DNCB-induced AD mice was significantly improved when treated with SHE. More importantly, we proved that SHE was able to decrease the serum levels of IgG₁ and IgG₂ₐ, two crucial factors of AD, indicating the protective effect of SHE. Taken together, our findings suggest that SHE may protect NC/Nga mice against DNCB-induced AD via promoting skin barrier function.
Identifiants
pubmed: 35634683
pii: HH-18-473
doi: 10.14670/HH-18-473
doi:
Substances chimiques
Anti-Inflammatory Agents
0
Cytokines
0
Dinitrobenzenes
0
Immunoglobulin G
0
Interleukin-13
0
Keratins
68238-35-7
Plant Extracts
0
Polyphenols
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
839-852Subventions
Organisme : Ministry of Oceans and Fisheries, Korea
ID : 20150306
Informations de copyright
©The Author(s) 2022. Open Access. This article is licensed under a Creative Commons CC-BY International License.
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