Flaxseed extract reduces tissue accumulation and enhances urinary excretion of chondroitin sulphate in the rat: a possible new path in substrate reduction therapy for mucopolysaccharidosis.
Antioxidant activity
chelating effect
chondroitin 6-sulphate
genistein
lignans
quercetin
Journal
Pharmaceutical biology
ISSN: 1744-5116
Titre abrégé: Pharm Biol
Pays: England
ID NLM: 9812552
Informations de publication
Date de publication:
Dec 2022
Dec 2022
Historique:
entrez:
31
5
2022
pubmed:
1
6
2022
medline:
3
6
2022
Statut:
ppublish
Résumé
Chondroitin 6 sulphate (C6S) is a glycosaminoglycan (GAG) whose accumulation is notable in mucopolysaccharidosis type IVA and VII. Flaxseed, We assess the effect of total ethanol flaxseed extract (EFSE) in an animal model of C6S accumulation. The study was performed in adult male Wistar rats ( Dry EFSE contains total phenols (6.28 mg EAG/g), condensed tannins (2.98 mg ECAT/g) and flavonoids (0.44 mg ECAT/g) with high antioxidant potential [RPE (IC EFSE showed significant potential for chelation. Its use for the treatment of GAG accumulation could be suggested and generalized to a larger study population.
Identifiants
pubmed: 35634909
doi: 10.1080/13880209.2022.2068618
pmc: PMC9477488
doi:
Substances chimiques
Antioxidants
0
Glycosaminoglycans
0
Plant Extracts
0
Chondroitin Sulfates
9007-28-7
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
879-888Références
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