A local human Vδ1 T cell population is associated with survival in nonsmall-cell lung cancer.
Journal
Nature cancer
ISSN: 2662-1347
Titre abrégé: Nat Cancer
Pays: England
ID NLM: 101761119
Informations de publication
Date de publication:
06 2022
06 2022
Historique:
received:
26
10
2021
accepted:
11
04
2022
pubmed:
1
6
2022
medline:
30
6
2022
entrez:
31
5
2022
Statut:
ppublish
Résumé
Murine tissues harbor signature γδ T cell compartments with profound yet differential impacts on carcinogenesis. Conversely, human tissue-resident γδ cells are less well defined. In the present study, we show that human lung tissues harbor a resident Vδ1 γδ T cell population. Moreover, we demonstrate that Vδ1 T cells with resident memory and effector memory phenotypes were enriched in lung tumors compared with nontumor lung tissues. Intratumoral Vδ1 T cells possessed stem-like features and were skewed toward cytolysis and helper T cell type 1 function, akin to intratumoral natural killer and CD8
Identifiants
pubmed: 35637401
doi: 10.1038/s43018-022-00376-z
pii: 10.1038/s43018-022-00376-z
pmc: PMC9236901
doi:
Substances chimiques
Receptors, Antigen, T-Cell, gamma-delta
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
696-709Subventions
Organisme : Medical Research Council
ID : MR/V033077/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_PC_17179
Pays : United Kingdom
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 220589/Z/20/Z
Pays : United Kingdom
Organisme : Cancer Research UK
ID : C11496/A30025
Pays : United Kingdom
Organisme : Cancer Research UK
ID : FC001169
Pays : United Kingdom
Organisme : Medical Research Council
ID : FC001169
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 203141/Z/16/Z
Pays : United Kingdom
Organisme : Department of Health
Pays : United Kingdom
Organisme : Wellcome Trust
ID : FC001169
Pays : United Kingdom
Organisme : Arthritis Research UK
ID : FC001169
Pays : United Kingdom
Investigateurs
Nicolai J Birkbak
(NJ)
Gillian Price
(G)
Mohammed Khalil
(M)
Keith Kerr
(K)
Shirley Richardson
(S)
Heather Cheyne
(H)
Tracey Cruickshank
(T)
Gareth A Wilson
(GA)
Rachel Rosenthal
(R)
Hugo Aerts
(H)
Madeleine Hewish
(M)
Girija Anand
(G)
Sajid Khan
(S)
Kelvin Lau
(K)
Michael Sheaff
(M)
Peter Schmid
(P)
Louise Lim
(L)
John Conibear
(J)
Roland Schwarz
(R)
Tom L Kaufmann
(TL)
Matthew Huska
(M)
Jacqui Shaw
(J)
Joan Riley
(J)
Lindsay Primrose
(L)
Dean Fennell
(D)
Allan Hackshaw
(A)
Yenting Ngai
(Y)
Abigail Sharp
(A)
Oliver Pressey
(O)
Sean Smith
(S)
Nicole Gower
(N)
Harjot Kaur Dhanda
(HK)
Kitty Chan
(K)
Sonal Chakraborty
(S)
Kevin Litchfield
(K)
Krupa Thakkar
(K)
Jonathan Tugwood
(J)
Alexandra Clipson
(A)
Caroline Dive
(C)
Dominic Rothwell
(D)
Alastair Kerr
(A)
Elaine Kilgour
(E)
Fiona Morgan
(F)
Malgorzata Kornaszewska
(M)
Richard Attanoos
(R)
Helen Davies
(H)
Katie Baker
(K)
Mathew Carter
(M)
Colin R Lindsay
(CR)
Fabio Gomes
(F)
Fiona Blackhall
(F)
Lynsey Priest
(L)
Matthew G Krebs
(MG)
Anshuman Chaturvedi
(A)
Pedro Oliveira
(P)
Zoltan Szallasi
(Z)
Gary Royle
(G)
Catarina Veiga
(C)
Marcin Skrzypski
(M)
Roberto Salgado
(R)
Miklos Diossy
(M)
Alan Kirk
(A)
Mo Asif
(M)
John Butler
(J)
Rocco Bilancia
(R)
Nikos Kostoulas
(N)
Mathew Thomas
(M)
Mairead MacKenzie
(M)
Maggie Wilcox
(M)
Apostolos Nakas
(A)
Sridhar Rathinam
(S)
Rebecca Boyles
(R)
Mohamad Tufail
(M)
Amrita Bajaj
(A)
Keng Ang
(K)
Mohammed Fiyaz Chowdhry
(MF)
Michael Shackcloth
(M)
Julius Asante-Siaw
(J)
Angela Leek
(A)
Nicola Totten
(N)
Jack Davies Hodgkinson
(JD)
Peter Van Loo
(P)
William Monteiro
(W)
Hilary Marshal
(H)
Kevin G Blyth
(KG)
Craig Dick
(C)
Charles Fekete
(C)
Eric Lim
(E)
Paulo De Sousa
(P)
Simon Jordan
(S)
Alexandra Rice
(A)
Hilgardt Raubenheimer
(H)
Harshil Bhayani
(H)
Morag Hamilton
(M)
Lyn Ambrose
(L)
Anand Devaraj
(A)
Hemangi Chavan
(H)
Sofina Begum
(S)
Silviu I Buderi
(SI)
Daniel Kaniu
(D)
Mpho Malima
(M)
Sarah Booth
(S)
Andrew G Nicholson
(AG)
Nadia Fernandes
(N)
Pratibha Shah
(P)
Chiara Proli
(C)
John Gosney
(J)
Sarah Danson
(S)
Jonathan Bury
(J)
John Edwards
(J)
Jennifer Hill
(J)
Sue Matthews
(S)
Yota Kitsanta
(Y)
Jagan Rao
(J)
Sara Tenconi
(S)
Laura Socci
(L)
Kim Suvarna
(K)
Faith Kibutu
(F)
Patricia Fisher
(P)
Robin Young
(R)
Joann Barker
(J)
Fiona Taylor
(F)
Kirsty Lloyd
(K)
Jason Lester
(J)
Mickael Escudero
(M)
Aengus Stewart
(A)
Andrew Rowan
(A)
Jacki Goldman
(J)
Richard Kevin Stone
(RK)
Tamara Denner
(T)
Emma Nye
(E)
Maria Greco
(M)
Jerome Nicod
(J)
Clare Puttick
(C)
Katey Enfield
(K)
Emma Colliver
(E)
Alastair Magness
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Chris Bailey
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Krijn Dijkstra
(K)
Vittorio Barbè
(V)
Roberto Vendramin
(R)
Judit Kisistok
(J)
Mateo Sokac
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Jonas Demeulemeester
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Elizabeth Larose Cadieux
(EL)
Carla Castignani
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Hongchang Fu
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Kristiana Grigoriadis
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Claudia Lee
(C)
Foteini Athanasopoulou
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Crispin Hiley
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Lily Robinson
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Tracey Horey
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Peter Russell
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Dionysis Papadatos-Pastos
(D)
Sara Lock
(S)
Kayleigh Gilbert
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Kayalvizhi Selvaraju
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Paul Ashford
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Oriol Pich
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Thomas B K Watkins
(TBK)
Sophia Ward
(S)
Emilia Lim
(E)
Alexander M Frankell
(AM)
Christopher Abbosh
(C)
Robert E Hynds
(RE)
Mariana Werner Sunderland
(MW)
Karl Peggs
(K)
Teresa Marafioti
(T)
John A Hartley
(JA)
Helen Lowe
(H)
Leah Ensell
(L)
Victoria Spanswick
(V)
Angeliki Karamani
(A)
David Moore
(D)
Stephan Beck
(S)
Olga Chervova
(O)
Miljana Tanic
(M)
Ariana Huebner
(A)
Michelle Dietzen
(M)
James R M Black
(JRM)
Carlos Martinez Ruiz
(CM)
Robert Bentham
(R)
Cristina Naceur-Lombardelli
(C)
Haoran Zhai
(H)
Nnennaya Kanu
(N)
Francisco Gimeno-Valiente
(F)
Supreet Kaur Bola
(SK)
Ignacio Garcia Matos
(IG)
Mansi Shah
(M)
Felipe Galvez Cancino
(FG)
Despoina Karagianni
(D)
Maryam Razaq
(M)
Mita Akther
(M)
Diana Johnson
(D)
Joanne Laycock
(J)
Elena Hoxha
(E)
Benny Chain
(B)
David R Pearce
(DR)
Kezhong Chen
(K)
Javier Herrero
(J)
Fleur Monk
(F)
Simone Zaccaria
(S)
Neil Magno
(N)
Paulina Prymas
(P)
Antonia Toncheva
(A)
Monica Sivakumar
(M)
Olivia Lucas
(O)
Mark S Hill
(MS)
Othman Al-Sawaf
(O)
Seng Kuong Ung
(SK)
Sam Gamble
(S)
Sophia Wong
(S)
David Lawrence
(D)
Martin Hayward
(M)
Nikolaos Panagiotopoulos
(N)
Robert George
(R)
Davide Patrini
(D)
Mary Falzon
(M)
Elaine Borg
(E)
Reena Khiroya
(R)
Asia Ahmed
(A)
Magali Taylor
(M)
Junaid Choudhary
(J)
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(SM)
Martin Forster
(M)
Tanya Ahmad
(T)
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(SM)
Neal Navani
(N)
Marco Scarci
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Pat Gorman
(P)
Elisa Bertoja
(E)
Robert C M Stephens
(RCM)
Emilie Martinoni Hoogenboom
(EM)
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(JW)
Steve Bandula
(S)
Ricky Thakrar
(R)
James Wilson
(J)
Mansi Shah
(M)
None Marcos
Vasquez Duran
(V)
Maria Litovchenko
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Sharon Vanloo
(S)
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(P)
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(K)
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(H)
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(C)
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(P)
Commentaires et corrections
Type : CommentIn
Informations de copyright
© 2022. The Author(s).
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