Short-chain fatty acids promote the effect of environmental signals on the gut microbiome and metabolome in mice.
Journal
Communications biology
ISSN: 2399-3642
Titre abrégé: Commun Biol
Pays: England
ID NLM: 101719179
Informations de publication
Date de publication:
31 05 2022
31 05 2022
Historique:
received:
27
05
2021
accepted:
09
05
2022
entrez:
31
5
2022
pubmed:
1
6
2022
medline:
3
6
2022
Statut:
epublish
Résumé
Gut microorganisms and the products of their metabolism thoroughly affect host brain development, function and behavior. Since alterations of brain plasticity and cognition have been demonstrated upon motor, sensorial and social enrichment of the housing conditions, we hypothesized that gut microbiota and metabolome could be altered by environmental stimuli, providing part of the missing link among environmental signals and brain effects. In this preliminary study, metagenomic and metabolomic analyses of mice housed in different environmental conditions, standard and enriched, identify environment-specific microbial communities and metabolic profiles. We show that mice housed in an enriched environment have distinctive microbiota composition with a reduction in gut bacterial richness and biodiversity and are characterized by a metabolomic fingerprint with the increase of formate and acetate and the decrease of bile salts. We demonstrate that mice treated with a mixture of formate and acetate recapitulate some of the brain plasticity effects modulated by environmental enrichment, such as hippocampal neurogenesis, neurotrophin production, short-term plasticity and cognitive behaviors, that can be further exploited to decipher the mechanisms involved in experience-dependent brain plasticity.
Identifiants
pubmed: 35641653
doi: 10.1038/s42003-022-03468-9
pii: 10.1038/s42003-022-03468-9
pmc: PMC9156677
doi:
Substances chimiques
Fatty Acids, Volatile
0
Formates
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
517Informations de copyright
© 2022. The Author(s).
Références
J Neurosci. 2004 May 19;24(20):4840-8
pubmed: 15152044
Proc Natl Acad Sci U S A. 2008 Feb 12;105(6):2117-22
pubmed: 18252821
Nature. 2012 Sep 13;489(7415):220-30
pubmed: 22972295
Nutrients. 2020 Jul 22;12(8):
pubmed: 32708052
Neuropeptides. 2013 Dec;47(6):431-8
pubmed: 24215800
Neuroscience. 2016 Aug 4;329:294-305
pubmed: 27208617
Neuropsychopharmacology. 2011 Aug;36(9):1823-36
pubmed: 21525862
Amino Acids. 2013 Sep;45(3):463-77
pubmed: 23615880
Microbiome. 2021 Jun 25;9(1):145
pubmed: 34172092
Front Microbiol. 2014 May 20;5:219
pubmed: 24904535
Nat Biotechnol. 2009 Oct;27(10):921-4
pubmed: 19816451
Front Cell Neurosci. 2011 Oct 19;5:22
pubmed: 22025910
Parkinsonism Relat Disord. 2016 Nov;32:66-72
pubmed: 27591074
Nat Rev Microbiol. 2012 Jul 16;10(8):538-50
pubmed: 22796884
Pharmacol Ther. 2022 Mar;231:107978
pubmed: 34492236
J Neurosci. 2020 Jan 29;40(5):1162-1173
pubmed: 31889008
PLoS One. 2018 Dec 6;13(12):e0208171
pubmed: 30521551
mSystems. 2020 Oct 6;5(5):
pubmed: 33024049
Brain Pathol. 2020 Nov;30(6):1159-1177
pubmed: 33073887
Eur J Neurosci. 2021 Aug;54(4):5235-5244
pubmed: 33458858
Nat Neurosci. 2015 Oct;18(10):1394-404
pubmed: 26404714
Brain Res. 1996 Jul 8;726(1-2):49-56
pubmed: 8836544
BMC Microbiol. 2014 Jul 15;14:189
pubmed: 25028050
Mol Psychiatry. 2016 Jun;21(6):738-48
pubmed: 27090305
J Biol Chem. 2003 Jul 11;278(28):25481-9
pubmed: 12711604
Lipids. 2005 Oct;40(10):1031-41
pubmed: 16382575
Nat Rev Microbiol. 2013 Apr;11(4):227-38
pubmed: 23435359
Microorganisms. 2020 Dec 25;9(1):
pubmed: 33375526
PLoS One. 2014 Sep 09;9(9):e106503
pubmed: 25202975
Mol Cell Neurosci. 2020 Jun;105:103493
pubmed: 32333962
Mol Psychiatry. 2009 Oct;14(10):959-67
pubmed: 19255582
J Lipid Res. 1988 Apr;29(4):509-22
pubmed: 3392467
Nat Genet. 2004 Aug;36(8):827-35
pubmed: 15258583
Rev Sci Tech. 2005 Aug;24(2):503-13
pubmed: 16358504
Psychoneuroendocrinology. 2015 Jul;57:72-83
pubmed: 25889841
PLoS One. 2013;8(1):e53793
pubmed: 23326507
Proc Natl Acad Sci U S A. 2002 Sep 3;99(18):11946-50
pubmed: 12181492
J Appl Bacteriol. 1992 Jan;72(1):57-64
pubmed: 1541601
PLoS Comput Biol. 2012;8(7):e1002606
pubmed: 22807668
J Biol Chem. 2003 Mar 28;278(13):11312-9
pubmed: 12496283
FASEB J. 2021 Feb;35(2):e21201
pubmed: 33496989
J Neurosci. 1994 Oct;14(10):5793-806
pubmed: 7931545
Cell Metab. 2021 Nov 2;33(11):2260-2276.e7
pubmed: 34731656
Mol Cell. 2016 Dec 1;64(5):982-992
pubmed: 27889451
Brain Res. 2007 Apr 13;1141:56-64
pubmed: 17292337
Curr Opin Immunol. 2016 Apr;39:75-81
pubmed: 26820225
Brain Behav Immun. 2021 Jan;91:472-486
pubmed: 33157257
Stat Med. 2008 May 20;27(11):1960-72
pubmed: 18338314
Cell Metab. 2012 Nov 7;16(5):559-64
pubmed: 23140640
Nat Rev Neurosci. 2000 Dec;1(3):191-8
pubmed: 11257907
Trends Endocrinol Metab. 2015 Sep;26(9):493-501
pubmed: 26257300
Cell Death Dis. 2020 May 4;11(5):310
pubmed: 32366892
J Physiol. 2018 Oct;596(20):4923-4944
pubmed: 30066368
Sci Rep. 2018 May 29;8(1):8210
pubmed: 29844325
J Child Psychol Psychiatry. 2020 Mar;61(3):353-371
pubmed: 31773737
Nucleic Acids Res. 2018 Jan 4;46(D1):D608-D617
pubmed: 29140435
Mol Neurobiol. 2021 Aug;58(8):3614-3627
pubmed: 33774742
Nat Neurosci. 2015 Jul;18(7):965-77
pubmed: 26030851
Front Cell Infect Microbiol. 2020 Jul 14;10:350
pubmed: 32760681
Nat Rev Neurosci. 2001 Jan;2(1):24-32
pubmed: 11253356
Cell. 2007 Dec 14;131(6):1164-78
pubmed: 18083105
Behav Brain Res. 2019 Dec 30;376:112183
pubmed: 31472194
Eur Urol. 2020 Aug;78(2):195-206
pubmed: 32376136
Brain Behav Immun. 2015 Nov;50:275-287
pubmed: 26209808
PLoS One. 2013 May 21;8(5):e64460
pubmed: 23700479
Physiol Rev. 2014 Jan;94(1):189-234
pubmed: 24382886
Nat Commun. 2015 Mar 30;6:6623
pubmed: 25818172
Nucleic Acids Res. 1999 Jan 1;27(1):29-34
pubmed: 9847135
FEBS Lett. 2018 Jun;592(12):2070-2082
pubmed: 29683480
Gastroenterology. 2011 Aug;141(2):599-609, 609.e1-3
pubmed: 21683077
Hippocampus. 2013 Jun;23(6):437-50
pubmed: 23460346
Elife. 2021 Apr 13;10:
pubmed: 33845942
Front Immunol. 2020 Jun 09;11:906
pubmed: 32582143
Eur J Neurosci. 2002 Sep;16(6):1107-16
pubmed: 12383240
Mol Cell Neurosci. 2009 Oct;42(2):81-9
pubmed: 19577647
Nat Rev Drug Discov. 2013 Sep;12(9):667-87
pubmed: 23989795
Neurochem Int. 2016 Oct;99:110-132
pubmed: 27346602
Neurosci Biobehav Rev. 2008 Jul;32(5):1055-70
pubmed: 18499253
Neuropharmacology. 2001 Nov;41(6):779-90
pubmed: 11640933
Handb Exp Pharmacol. 2017;236:17-32
pubmed: 27757758
Neurochem Int. 2009 Sep;55(4):208-13
pubmed: 19524110
Behav Brain Res. 2019 Aug 5;368:111917
pubmed: 31004685
Biochem Biophys Res Commun. 2003 Apr 18;303(4):1047-52
pubmed: 12684041
Neurobiol Learn Mem. 2004 May;81(3):200-10
pubmed: 15082021
Growth Factors. 2004 Sep;22(3):123-31
pubmed: 15518235
Biochimie. 2016 Jul;126:63-70
pubmed: 26924399
Nutrients. 2020 Dec 07;12(12):
pubmed: 33297486
Curr Opin Clin Nutr Metab Care. 2011 Sep;14(5):477-82
pubmed: 21832903