Identification of the Major Product of Guanine Oxidation in DNA by Ozone.

DNA / chemistry Guanine / chemistry Guanosine Nucleosides / chemistry Oligodeoxyribonucleotides / metabolism Oxidation-Reduction Ozone Singlet Oxygen Solvents

Journal

Chemical research in toxicology
ISSN: 1520-5010
Titre abrégé: Chem Res Toxicol
Pays: United States
ID NLM: 8807448

Informations de publication

Date de publication:
17 10 2022
Historique:
pubmed: 2 6 2022
medline: 19 10 2022
entrez: 1 6 2022
Statut: ppublish

Résumé

Ozonolysis of guanosine formed the 5-carboxamido-5-formamido-2-iminohydantoin (2Ih) nucleoside along with trace spiroiminodihydantoin (Sp). On the basis of literature precedent, we propose an unconventional ozone mechanism involving incorporation of only one oxygen atom of O

Identifiants

DOI: 10.1021/acs.chemrestox.2c00103 PMID: 35642826
pubmed: 35642826
doi: 10.1021/acs.chemrestox.2c00103
doi:

Substances chimiques

Nucleosides 0
Oligodeoxyribonucleotides 0
Solvents 0
Guanosine 12133JR80S
Singlet Oxygen 17778-80-2
Guanine 5Z93L87A1R
Ozone 66H7ZZK23N
DNA 9007-49-2

Types de publication

Journal Article Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

1809-1813

Auteurs

Michael B Chabot (MB)

Department of Chemistry, University of Utah, 315 S. 1400 E., Salt Lake City, Utah 84112-0850, United States.

Aaron M Fleming (AM)

Department of Chemistry, University of Utah, 315 S. 1400 E., Salt Lake City, Utah 84112-0850, United States.
ORCID: 0000-0002-2000-0310

Cynthia J Burrows (CJ)

Department of Chemistry, University of Utah, 315 S. 1400 E., Salt Lake City, Utah 84112-0850, United States.
ORCID: 0000-0001-7253-8529

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Classifications MeSH

questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ADN › Identification of the Major Product of Guanine...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Purines › Purinones › Hypoxanthines › Guanine › Identification of the Major Product of Guanine...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléosides › Ribonucléosides › Guanosine › Identification of the Major Product of Guanine...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléosides › Identification of the Major Product of Guanine...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléotides › Polynucléotides › Oligonucléotides › Oligodésoxyribonucléotides › Identification of the Major Product of Guanine...
questionsmedicales.fr › Métabolisme › Métabolisme énergétique › Oxydoréduction › Identification of the Major Product of Guanine...
questionsmedicales.fr › Produits chimiques inorganiques › Gaz › Oxygène › Ozone › Identification of the Major Product of Guanine...
questionsmedicales.fr › Produits chimiques inorganiques › Oxygène singulet › Identification of the Major Product of Guanine...
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Solvants › Identification of the Major Product of Guanine...