Effects of enriched seafood sticks (heat-inactivated B. animalis subsp. lactis CECT 8145, inulin, omega-3) on cardiometabolic risk factors and gut microbiota in abdominally obese subjects: randomized controlled trial.
Cardiometabolic disease
Gut microbiota
Inulin
Omega 3
Postbiotics
Type 2 diabetes management
Journal
European journal of nutrition
ISSN: 1436-6215
Titre abrégé: Eur J Nutr
Pays: Germany
ID NLM: 100888704
Informations de publication
Date de publication:
Oct 2022
Oct 2022
Historique:
received:
10
01
2022
accepted:
05
05
2022
pubmed:
2
6
2022
medline:
14
9
2022
entrez:
1
6
2022
Statut:
ppublish
Résumé
To assess the effects of enriched seafood sticks with postbiotic and bioactive compounds on CMD risk factors and the gut microbiota in abdominally obese individuals. Randomized, double-blind, parallel, placebo-controlled trial with abdominally obese individuals. Participants (n = 120) consumed 50 g/day of enriched seafood sticks containing SIAP: (10 Sustained SIAP2 consumption significantly decreased the insulin by - 5.25 mg/dL and HOMA-IR (homeostatic Model Assessment of Insulin Resistance) by - 1.33. In women, SIAP2 consumption significantly decreased the pulse pressure (PP) by - 4.69 mmHg. Gut microbiota analysis showed a negative association between glycemic parameter reduction and Alistipes finegoldii and Ruminococcaceae, and between PP reduction and Prevotella 9-ASV0283 and Christensenellaceae. In the acute single dose-study 4-h, SIAP2 consumption produced a lower increase in the postprandial circulating triglyceride levels [23.9 (7.03) mg/dL (mean [standard error])] than the observed with placebo [49.0 (9.52)] mg/dL. In abdominally obese individuals, enriched seafood sticks induce a potential protection against type 2 diabetes development by the reduction in the insulin and HOMA-IR; and in cardiovascular disease, in women, by the PP reduction. These effects are accompanied by partial changes in the gut microbiota composition. The enriched seafood sticks reduce the atherogenic triglyceride postprandial concentrations. Our results support the use of enriched seafood sticks as a complementary strategy in the management of CMD risk factors. REGISTRATION NUMBER OF CLINICAL TRIAL: ( www. gov ): NCT03630588 (August 15, 2018).
Identifiants
pubmed: 35643872
doi: 10.1007/s00394-022-02904-0
pii: 10.1007/s00394-022-02904-0
pmc: PMC9464132
doi:
Substances chimiques
Fatty Acids, Omega-3
0
Insulin
0
Triglycerides
0
Inulin
9005-80-5
Banques de données
ClinicalTrials.gov
['NCT03630588']
Types de publication
Journal Article
Randomized Controlled Trial
Langues
eng
Sous-ensembles de citation
IM
Pagination
3597-3611Subventions
Organisme : Centre for Industrial Technological Development
ID : CER-20191010
Informations de copyright
© 2022. The Author(s).
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