Diazepinone HBV capsid assembly modulators.

Antiviral Agents / metabolism Capsid / metabolism Capsid Proteins / metabolism Hepatitis B virus / metabolism Virus Assembly
Capsid Diazepinone HBV

Journal

Bioorganic & medicinal chemistry letters
ISSN: 1464-3405
Titre abrégé: Bioorg Med Chem Lett
Pays: England
ID NLM: 9107377

Informations de publication

Date de publication:
15 09 2022
Historique:
received: 30 03 2022
revised: 19 05 2022
accepted: 23 05 2022
pubmed: 2 6 2022
medline: 27 7 2022
entrez: 1 6 2022
Statut: ppublish

Résumé

The HBV capsid core protein serves a number of important functions in the viral life cycle enabling chronic HBV infection to persist, and therefore is a promising drug target. Interfering with capsid assembly has shown efficacy in clinical trials with small molecule capsid assembly modulators (CAMs). Herein is described the further optimization of a progressive series of diazepinone HBV CAMs.

Identifiants

DOI: 10.1016/j.bmcl.2022.128823 PMID: 35644301
pubmed: 35644301
pii: S0960-894X(22)00299-2
doi: 10.1016/j.bmcl.2022.128823
pii:
doi:

Substances chimiques

Antiviral Agents 0
Capsid Proteins 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

128823

Informations de copyright

Copyright © 2022 Elsevier Ltd. All rights reserved.

Auteurs

Scott D Kuduk (SD)

Janssen Research and Development, 1400 McKean Road, Spring House, PA 19477, United States. Electronic address: skuduk@its.jnj.com.

Lindsey G DeRatt (LG)

Janssen Research and Development, 1400 McKean Road, Spring House, PA 19477, United States.

Bart Stoops (B)

Janssen Pharmaceutica, NV Turnhoutseweg 30, 2340 Beerse, Belgium.

Paul Shaffer (P)

Janssen Research and Development, 1400 McKean Road, Spring House, PA 19477, United States.

Angela M Lam (AM)

Janssen Research and Development, 1400 McKean Road, Spring House, PA 19477, United States.

Christine Espiritu (C)

Janssen Research and Development, 1400 McKean Road, Spring House, PA 19477, United States.

Robert Vogel (R)

Janssen Research and Development, 1400 McKean Road, Spring House, PA 19477, United States.

Vincent Lau (V)

Janssen Research and Development, 1400 McKean Road, Spring House, PA 19477, United States.

Osvaldo A Flores (OA)

Janssen Research and Development, 1400 McKean Road, Spring House, PA 19477, United States.

George D Hartman (GD)

Janssen Research and Development, 1400 McKean Road, Spring House, PA 19477, United States.

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antiviraux › Diazepinone HBV capsid assembly modulators.
questionsmedicales.fr › Structures virales › Virion › Nucléocapside › Capside › Diazepinone HBV capsid assembly modulators.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines virales › Protéines virales structurales › Protéines nucléocapside › Protéines de capside › Diazepinone HBV capsid assembly modulators.
questionsmedicales.fr › Virus › Virus de l'hépatite › Hepadnaviridae › Orthohepadnavirus › Virus de l'hépatite B › Diazepinone HBV capsid assembly modulators.
questionsmedicales.fr › Phénomènes microbiologiques › Phénomènes physiologiques viraux › Réplication virale › Assemblage viral › Diazepinone HBV capsid assembly modulators.