Epidemiological and Genetic Insights of the Circulating Foot-and-Mouth Disease Virus Serotypes in Egypt.
Journal
Current microbiology
ISSN: 1432-0991
Titre abrégé: Curr Microbiol
Pays: United States
ID NLM: 7808448
Informations de publication
Date de publication:
30 Oct 2024
30 Oct 2024
Historique:
received:
09
03
2024
accepted:
08
10
2024
medline:
31
10
2024
pubmed:
31
10
2024
entrez:
31
10
2024
Statut:
epublish
Résumé
Foot-and-mouth disease virus (FMDV) remains a major threat to livestock in Egypt, with ongoing outbreaks involving serotypes A, O, and SAT2. This study aimed to improve the understanding of these circulating FMDV strains to improve control measures. Between 2022 and 2023, 134 cattle samples from across Egypt were analyzed, revealing a 67.9% positivity rate for Pan FMDV. Of these positive samples, 64 were identified as serotype A and 27 as serotype O. Genetic analysis indicated that serotype O strains clustered within the EA-3 topotype, suggesting endemic persistence and potential vaccine evasion, while serotype A strains were associated with the African topotype and linked to regions such as Ethiopia, Kenya, and Sudan. Notable amino acid mutations in the VP1 protein of both serotypes highlighted potential challenges to vaccine effectiveness. These findings underscore the need for enhanced surveillance, timely vaccine updates, and regional cooperation to effectively manage FMD outbreaks in Egypt and neighboring countries.
Identifiants
pubmed: 39477883
doi: 10.1007/s00284-024-03944-x
pii: 10.1007/s00284-024-03944-x
doi:
Substances chimiques
Capsid Proteins
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
435Informations de copyright
© 2024. The Author(s).
Références
Diab E, Bazid AI, Fawzy M, El-Ashmawy WR, Fayed AA, El-Sayed MM (2019) Foot-and-mouth disease outbreaks in Egypt during 2013–2014: molecular characterization of serotypes A, O, and SAT2. Vet World 12(2):190–197. https://doi.org/10.14202/vetworld.2019.190-197
doi: 10.14202/vetworld.2019.190-197
pubmed: 31040557
pmcid: 6460869
Abdulrahman DA, El-Deeb AH, Shafik NG, Shaheen MA, Hussein HA (2019) Mutations in foot and mouth disease virus types A and O isolated from vaccinated animals. Rev Sci Tech 38(3):663–680
doi: 10.20506/rst.38.3.3016
pubmed: 32286577
Lycett S, Tanya VN, Hall M, King DP, Mazeri S, Mioulet V, Knowles NJ, Wadsworth J, Bachanek-Bankowska K, Ngu Ngwa V, Morgan KL, Bronsvoort BMC (2019) The evolution and phylodynamics of serotype A and SAT2 foot-and-mouth disease viruses in endemic regions of Africa. Sci Rep 9(1):5614. https://doi.org/10.1038/s41598-019-41995-4
doi: 10.1038/s41598-019-41995-4
pubmed: 30948742
pmcid: 6449503
Woldemariyam FT, Kariuki CK, Kamau J, De Vleeschauwer A, De Clercq K, Lefebvre DJ, Paeshuyse J (2023) Epidemiological dynamics of foot-and-mouth disease in the Horn of Africa: the role of virus diversity and animal movement. Viruses 15(4):969. https://doi.org/10.3390/v15040969
doi: 10.3390/v15040969
pubmed: 37112947
pmcid: 10143177
Li K, Wang C, Yang F, Cao W, Zhu Z, Zheng H (2021) Virus-host interactions in foot-and-mouth disease virus infection. Front Immunol 12:571509. https://doi.org/10.3389/fimmu.2021.571509
doi: 10.3389/fimmu.2021.571509
pubmed: 33717061
pmcid: 7952751
Bertram MR, Yadav S, Stenfeldt C, Delgado A, Arzt J (2020) Extinction dynamics of the foot-and-mouth disease virus carrier state under natural conditions. Front Vet Sci 7:276. https://doi.org/10.3389/fvets.2020.00276
doi: 10.3389/fvets.2020.00276
pubmed: 32509810
pmcid: 7249781
Knight-Jones TJD, McLaws M, Rushton J (2017) Foot-and-mouth disease impact on small-holders - what do we know, what don’t we know and how can we find out more? Transbound Emerg Dis 64(4):1079–1094. https://doi.org/10.1111/tbed.12507
doi: 10.1111/tbed.12507
pubmed: 27167976
Brown E, Nelson N, Gubbins S, Colenutt C (2022) Airborne transmission of foot-and-mouth disease virus: a review of past and present perspectives. Viruses 14(5):1009. https://doi.org/10.3390/v14051009
doi: 10.3390/v14051009
pubmed: 35632750
pmcid: 9145556
Abd-Ellatieff HA, Hegazy AA, AbouRawash AA, Tohamy HG, Al-Shehri M, Bazh EK, Hassan H, Essa BH (2023) Pathological and genetic characterization of foot and mouth disease viruses collected from cattle and water buffalo in Egypt. PLoS One 18(10):e0291970. https://doi.org/10.1371/journal.pone.0291970
doi: 10.1371/journal.pone.0291970
pubmed: 37819946
pmcid: 10566709
Metwally S, Bkear N, Badr Y, Elshafey B, Alhag SK, Al-Shuraym LA, Batiha G, Fakhry B, Hamada R (2023) A newly emerging serotype a strain in foot-and-mouth disease virus with higher severity and mortality in buffalo than in cattle calves in North Egypt. Vet Sci 10(8):488. https://doi.org/10.3390/vetsci10080488
doi: 10.3390/vetsci10080488
pubmed: 37624275
pmcid: 10457878
Elhaig MM, Elsheery MN (2014) Molecular investigation of foot-and-mouth disease virus in domestic bovids from Gharbia, Egypt. Trop Anim Health Prod 46(8):1455–1462. https://doi.org/10.1007/s11250-014-0665-7
doi: 10.1007/s11250-014-0665-7
pubmed: 25187028
Soltan MA, Mahmoud MM, Hegazy Y, Abd-Eldiam MM (2022) Emergence of foot and mouth disease virus, serotype O, Europe-South America topotype in Egypt, 2022. Transbound Emerg Dis 69(5):2409–2411. https://doi.org/10.1111/tbed.14612
doi: 10.1111/tbed.14612
pubmed: 35679058
Abd El-Rhman MM, Salem SA, Bazid AI, Abo El-Hassan DJ (2021) Molecular and serological typing of foot-and-mouth disease virus serotypes currently circulating in Egypt. Iraqi J Vet Sci 35(3):581–588. https://doi.org/10.33899/IJVS.2020.127327.1495
doi: 10.33899/IJVS.2020.127327.1495
Sobhy NM, Bayoumi YH, Mor SK, El-Zahar HI, Goyal SM (2018) Outbreaks of foot and mouth disease in Egypt: molecular epidemiology, evolution and cardiac biomarkers prognostic significance. Int J Vet Sci Med 6(1):22–30. https://doi.org/10.1016/j.ijvsm.2018.02.001
doi: 10.1016/j.ijvsm.2018.02.001
pubmed: 30255074
pmcid: 6148740
Singanallur NB, Eblé PL, Ludi AB, Statham B, Bin-Tarif A, King DP, Dekker A, Vosloo W (2022) A vaccine based on the A/ASIA/G-VII lineage of foot-and-mouth disease virus offers low levels of protection against circulating viruses from the A/ASIA/Iran-05 lineage. Viruses 14(1):97. https://doi.org/10.3390/v14010097
doi: 10.3390/v14010097
pubmed: 35062300
pmcid: 8781018
Hassan AM, Zaher MR, Hassanien RT, Abd-El-Moniem MI, Habashi AR, Ibraheem EM, Shahein MA, El Zowalaty ME, Hagag NM (2022) Molecular detection, phylogenetic analysis and genetic diversity of recently isolated foot-and-mouth disease virus serotype A African topotype, Genotype IV. Virol J 19(1):1. https://doi.org/10.1186/s12985-021-01693-y
doi: 10.1186/s12985-021-01693-y
pubmed: 34980196
pmcid: 8722054
Hagag NM, Hassan AM, Zaher MR, Elnomrosy SM, Shemies OA, Hussein HA, Ahmed ES, Ali MH, Ateay M, Abdel-Hakim MA, Habashi AR, Eid S, El Zowalaty ME, Shahein MA (2023) Molecular detection and phylogenetic analysis of newly emerging foot-and-mouth disease virus type A, Lineage EURO-SA in Egypt in 2022. Virus Res 323:198960. https://doi.org/10.1016/j.virusres.2022.198960
doi: 10.1016/j.virusres.2022.198960
pubmed: 36209919
Shahein MA, Hussein HA, Ali MH, Ghoniem SM, Shemies OA, Afify AF, Fuoad AA, Hassan AM, Zaher MR, Ela NHA, Habashi AR, Eid S, Hagag NM (2023) Circulating foot-and-mouth disease virus serotype A African-genotype IV in Egypt during 2022. Vet World 16(7):1429–1437. https://doi.org/10.14202/vetworld.2023.1429-1437
doi: 10.14202/vetworld.2023.1429-1437
pubmed: 37621542
pmcid: 10446720
Al-Hosary AA, Kandeil A, El-Taweel AN, Nordengrahn A, Merza M, Badra R, Kayali G, Ali MA (2019) Co-infection with different serotypes of FMDV in vaccinated cattle in Southern Egypt. Virus Genes 55(3):304–313. https://doi.org/10.1007/s11262-019-01645-3
doi: 10.1007/s11262-019-01645-3
pubmed: 30771081
Singh RK, Sharma GK, Mahajan S, Dhama K, Basagoudanavar SH, Hosamani M, Sreenivasa BP, Chaicumpa W, Gupta VK, Sanyal A (2019) Foot-and-mouth disease virus: immunobiology, advances in vaccines and vaccination strategies addressing vaccine failures-an Indian perspective. Vaccines 7(3):90. https://doi.org/10.3390/vaccines7030090
doi: 10.3390/vaccines7030090
pubmed: 31426368
pmcid: 6789522
Eid SA, Alagmy GN, Hamed TA, Abdelwahed DA, Salah S (2022) Immunological studies on cattle naturally infected with FMD compared with the vaccinated cattle in Sharkia Governorate, Egypt. J Adv Vet Res 12(6):694–705
WOAH. Foot and mouth disease. Chapter 3.1.8. Terrestrial Animal Health Code. World Organization for Animal Health, Paris, France. https://www.oie.int/fleadmin/Home/eng/Health_standards/tahm/3.01.08_FMD.pdf . Accessed 2 Feb 2024
Knowles NJ, Wadsworth J, Bachanek-Bankowska K, King DP (2016) VP1 sequencing protocol for foot and mouth disease virus molecular epidemiology. Rev Sci Tech 35:741–755. https://doi.org/10.20506/rst.35.3.2565
doi: 10.20506/rst.35.3.2565
pubmed: 28332654
Reid SM, Ferris NP, Brüning A, Hutchings GH, Kowalska Z, Akerblom L (2001) Development of a rapid chromatographic strip test for the pen-side detection of foot-and-mouth disease virus antigen. J Virol Methods 96(2):189–202. https://doi.org/10.1016/s0166-0934(01)00334-2
doi: 10.1016/s0166-0934(01)00334-2
pubmed: 11445149
Muhire BM, Varsani A, Martin DP (2014) SDT: a virus classification tool based on pairwise sequence alignment and identity calculation. PLoS One 9(9):e108277. https://doi.org/10.1371/journal.pone.0108277
doi: 10.1371/journal.pone.0108277
pubmed: 25259891
pmcid: 4178126
Tamura K, Stecher G, Kumar S (2021) MEGA11: Molecular evolutionary genetics analysis version 11. Mol Biol Evol 38(7):3022–3027. https://doi.org/10.1093/molbev/msab120
doi: 10.1093/molbev/msab120
pubmed: 33892491
pmcid: 8233496
Stamatakis A (2014) RAxML version 8: a tool for phylogenetic analysis and post-analysis of large phylogenies. Bioinformatics 30(9):1312–1313. https://doi.org/10.1093/bioinformatics/btu033
doi: 10.1093/bioinformatics/btu033
pubmed: 24451623
pmcid: 3998144
Guindon S, Dufayard JF, Lefort V, Anisimova M, Hordijk W, Gascuel O (2010) New algorithms and methods to estimate maximum-likelihood phylogenies: assessing the performance of PhyML 3.0. Syst Biol 59(3):307–321. https://doi.org/10.1093/sysbio/syq010
doi: 10.1093/sysbio/syq010
pubmed: 20525638
Haydon D, Lea S, Fry L, Knowles N, Samuel AR, Stuart D, Woolhouse ME (1998) Characterizing sequence variation in the VP1 capsid proteins of foot and mouth disease virus (serotype 0) with respect to virion structure. Mol Evol 46:465–475. https://doi.org/10.1007/pl00006327
doi: 10.1007/pl00006327
Salem R, El-Kholy AA, Omar OA, Abu El-Naga MN, Ibrahim M, Osman G (2019) Construction, expression and evaluation of recombinant VP2 protein for serotype-independent detection of FMDV seropositive animals in Egypt. Sci Rep 9(1):10135. https://doi.org/10.1038/s41598-019-46596-9
doi: 10.1038/s41598-019-46596-9
pubmed: 31300744
pmcid: 6626030
Ferretti L, Di Nardo A, Singer B, Lasecka-Dykes L, Logan G, Wright CF, Pérez-Martín E, King DP, Tuthill TJ, Ribeca P (2018) Within-host recombination in the foot-and-mouth disease virus genome. Viruses 10(5):221. https://doi.org/10.3390/v10050221
doi: 10.3390/v10050221
pubmed: 29693634
pmcid: 5977214
Ward JC, Lasecka-Dykes L, Neil C, Adeyemi OO, Gold S, McLean-Pell N, Wright C, Herod MR, Kealy D, Warner E, Jackson T, King DP, Tuthill TJ, Rowlands DJ, Stonehouse NJ (2022) The RNA pseudoknots in foot-and-mouth disease virus are dispensable for genome replication, but essential for the production of infectious virus. PLoS Pathog 18(6):e1010589. https://doi.org/10.1371/journal.ppat.1010589
doi: 10.1371/journal.ppat.1010589
pubmed: 35666744
pmcid: 9203018
Grazioli S, Fallacara F, Brocchi E (2013) Mapping of antigenic sites of foot-and-mouth disease virus serotype Asia 1 and relationships with sites described in other serotypes. J Gen Virol 94(Pt 3):559–569. https://doi.org/10.1099/vir.0.048249-0
doi: 10.1099/vir.0.048249-0
pubmed: 23197575
Florian D, Bronsvoort BMC, Samantha L (2019) Phylogeographic analysis and identification of factors impacting the diffusion of foot-and-mouth disease virus in Africa. Front Ecol Evol 7:371. https://doi.org/10.3389/fevo.2019.00371
doi: 10.3389/fevo.2019.00371