Forward Genetics in Apicomplexa Biology: The Host Side of the Story.
CRISPR-Cas9
ENU
QTL
RNAi
apicomplexa
classical genetics
forward genetic screens
host immunity
Journal
Frontiers in cellular and infection microbiology
ISSN: 2235-2988
Titre abrégé: Front Cell Infect Microbiol
Pays: Switzerland
ID NLM: 101585359
Informations de publication
Date de publication:
2022
2022
Historique:
received:
18
02
2022
accepted:
31
03
2022
entrez:
1
6
2022
pubmed:
2
6
2022
medline:
7
6
2022
Statut:
epublish
Résumé
Forward genetic approaches have been widely used in parasitology and have proven their power to reveal the complexities of host-parasite interactions in an unbiased fashion. Many aspects of the parasite's biology, including the identification of virulence factors, replication determinants, antibiotic resistance genes, and other factors required for parasitic life, have been discovered using such strategies. Forward genetic approaches have also been employed to understand host resistance mechanisms to parasitic infection. Here, we will introduce and review all forward genetic approaches that have been used to identify host factors involved with Apicomplexa infections, which include classical genetic screens and QTL mapping, GWAS, ENU mutagenesis, overexpression, RNAi and CRISPR-Cas9 library screens. Collectively, these screens have improved our understanding of host resistance mechanisms, immune regulation, vaccine and drug designs for Apicomplexa parasites. We will also discuss how recent advances in molecular genetics give present opportunities to further explore host-parasite relationships.
Identifiants
pubmed: 35646724
doi: 10.3389/fcimb.2022.878475
pmc: PMC9133346
doi:
Types de publication
Journal Article
Review
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
878475Subventions
Organisme : NIAID NIH HHS
ID : R01 AI137126
Pays : United States
Organisme : NIAID NIH HHS
ID : R21 AI145403
Pays : United States
Informations de copyright
Copyright © 2022 Sánchez-Arcila and Jensen.
Déclaration de conflit d'intérêts
The authors declare that the review was conducted and written in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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