Differentiation of Parkinson's disease tremor and essential tremor based on a novel hand posture.
Accelerometry
Essential tremor
Hand postures
Parkinson's disease
Tremor
Journal
Clinical parkinsonism & related disorders
ISSN: 2590-1125
Titre abrégé: Clin Park Relat Disord
Pays: England
ID NLM: 101761473
Informations de publication
Date de publication:
2022
2022
Historique:
received:
21
02
2022
revised:
04
05
2022
accepted:
14
05
2022
entrez:
1
6
2022
pubmed:
2
6
2022
medline:
2
6
2022
Statut:
epublish
Résumé
Tremor is one of the most common movement disorders but the correct diagnosis of tremor disorders, especially the differentiation between Parkinson's disease tremor (PT) and essential tremor (ET) remains a challenge for clinicians. We examined a novel hand position to distinguish PT from ET. We prospectively collected accelerometric tremor data in 14 ET patients and 14 PT patients with arms and hands fully stretched against arms stretched and hands relaxed, i. e. hanging down. The total acceleration from the three pairwise-perpendicular accelerometric axes during the 1-minute blocks of the two hand positions were computed and high-passed filtered at 2 Hz. The power spectral density during each hand position was calculated and summed up over the frequency domain. Our results showed a significantly higher occurrence of tremor in the hands hanging down position in PT patients compared to ET patients ( In conclusion, the new hand posture can differentiate between PT and ET with high accuracy (sensitivity 83 %, specificity 75 % for PT) and may be a helpful tool in the clinical assessment of tremor.
Sections du résumé
Background
UNASSIGNED
Tremor is one of the most common movement disorders but the correct diagnosis of tremor disorders, especially the differentiation between Parkinson's disease tremor (PT) and essential tremor (ET) remains a challenge for clinicians.
Method
UNASSIGNED
We examined a novel hand position to distinguish PT from ET. We prospectively collected accelerometric tremor data in 14 ET patients and 14 PT patients with arms and hands fully stretched against arms stretched and hands relaxed, i. e. hanging down. The total acceleration from the three pairwise-perpendicular accelerometric axes during the 1-minute blocks of the two hand positions were computed and high-passed filtered at 2 Hz. The power spectral density during each hand position was calculated and summed up over the frequency domain.
Results
UNASSIGNED
Our results showed a significantly higher occurrence of tremor in the hands hanging down position in PT patients compared to ET patients (
Conclusion
UNASSIGNED
In conclusion, the new hand posture can differentiate between PT and ET with high accuracy (sensitivity 83 %, specificity 75 % for PT) and may be a helpful tool in the clinical assessment of tremor.
Identifiants
pubmed: 35647517
doi: 10.1016/j.prdoa.2022.100146
pii: S2590-1125(22)00017-2
pmc: PMC9136132
doi:
Types de publication
Journal Article
Langues
eng
Pagination
100146Informations de copyright
© 2022 The Author(s).
Déclaration de conflit d'intérêts
The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
Références
J Neurol Neurosurg Psychiatry. 1999 Nov;67(5):646-50
pubmed: 10519872
Clin Park Relat Disord. 2020 Aug 05;3:100066
pubmed: 34316646
Neuroimage. 2018 Aug 15;177:20-29
pubmed: 29738912
Brain. 2017 Jul 1;140(7):1977-1986
pubmed: 28459950
Mov Disord. 2008 Nov 15;23(15):2129-70
pubmed: 19025984
Parkinsonism Relat Disord. 2012 Jan;18 Suppl 1:S87-9
pubmed: 22166465
Neurology. 2016 Feb 9;86(6):566-76
pubmed: 26764028
Mov Disord. 2008 Nov 15;23(15):2202-9
pubmed: 18785639
J Neurol Neurosurg Psychiatry. 1988 Jun;51(6):745-52
pubmed: 2841426
Annu Int Conf IEEE Eng Med Biol Soc. 2011;2011:2237-41
pubmed: 22254785
J Parkinsons Dis. 2015;5(3):471-4
pubmed: 26406126
Arch Neurol. 2006 Aug;63(8):1100-4
pubmed: 16908735
Neurology. 2012 Mar 6;78(10):696-701
pubmed: 22323748
Mov Disord. 1998;13 Suppl 3:2-23
pubmed: 9827589
Mov Disord. 2019 Apr;34(4):575-579
pubmed: 30788866
Mov Disord. 2011 Jul;26(8):1548-52
pubmed: 21520285
Mov Disord. 2018 Jan;33(1):75-87
pubmed: 29193359
Parkinsonism Relat Disord. 2014 Nov;20(11):1283-6
pubmed: 25260965
Parkinsonism Relat Disord. 2013 Jul;19(7):693-7
pubmed: 23623196
Parkinsonism Relat Disord. 2021 Nov;92:53-58
pubmed: 34695656
Biomed Mater Eng. 2013;23(6):513-31
pubmed: 24165554
Arch Neurol. 2003 Mar;60(3):405-10
pubmed: 12633153