Mesaconate is synthesized from itaconate and exerts immunomodulatory effects in macrophages.

Animals Inflammasomes Macrophages / drug effects Mice RAW 264.7 Cells Succinates / metabolism

Journal

Nature metabolism
ISSN: 2522-5812
Titre abrégé: Nat Metab
Pays: Germany
ID NLM: 101736592

Informations de publication

Date de publication:
05 2022
Historique:
received: 19 05 2021
accepted: 25 03 2022
pubmed: 3 6 2022
medline: 9 6 2022
entrez: 2 6 2022
Statut: ppublish

Résumé

Since its discovery in inflammatory macrophages, itaconate has attracted much attention due to its antimicrobial and immunomodulatory activity

Identifiants

DOI: 10.1038/s42255-022-00565-1 PMID: 35655024 PMC: PMC9744384
pubmed: 35655024
doi: 10.1038/s42255-022-00565-1
pii: 10.1038/s42255-022-00565-1
pmc: PMC9744384
mid: NIHMS1845380
doi:

Substances chimiques

Inflammasomes 0
Succinates 0
itaconic acid Q4516562YH

Types de publication

Journal Article Research Support, Non-U.S. Gov't Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

524-533

Subventions

Organisme : NHLBI NIH HHS
ID : HHSN268201300022C
Pays : United States

Commentaires et corrections

Type : CommentIn

Informations de copyright

© 2022. The Author(s), under exclusive licence to Springer Nature Limited.

Références

Michelucci, A. et al. Immune-responsive gene 1 protein links metabolism to immunity by catalyzing itaconic acid production. Proc. Natl Acad. Sci. USA 110, 7820–7825 (2013).
doi: 10.1073/pnas.1218599110
Mills, E. L. et al. Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1. Nature 556, 113–117 (2018).
doi: 10.1038/nature25986
Bambouskova, M. et al. Electrophilic properties of itaconate and derivatives regulate the IκBζ–ATF3 inflammatory axis. Nature 556, 501–504 (2018).
doi: 10.1038/s41586-018-0052-z
Wynn, T. A., Chawla, A. & Pollard, J. W. Macrophage biology in development, homeostasis and disease. Nature 496, 445–455 (2013).
doi: 10.1038/nature12034
He, W., Heinz, A., Jahn, D. & Hiller, K. Complexity of macrophage metabolism in infection. Curr. Opin. Biotechnol. 68, 231–239 (2021).
doi: 10.1016/j.copbio.2021.01.020
Cordes, T. et al. Immunoresponsive gene 1 and itaconate inhibit succinate dehydrogenase to modulate intracellular succinate levels. J. Biol. Chem. 291, 14274–14284 (2016).
doi: 10.1074/jbc.M115.685792
Nemeth, B. et al. Abolition of mitochondrial substrate-level phosphorylation by itaconic acid produced by LPS-induced Irg1 expression in cells of murine macrophage lineage. FASEB J. 30, 286–300 (2016).
doi: 10.1096/fj.15-279398
Cordes, T. & Metallo, C. M. Itaconate alters succinate and coenzyme a metabolism via Inhibition of mitochondrial complex II and methylmalonyl-CoA mutase. Metabolites 11, 117 (2021).
Lampropoulou, V. et al. Itaconate links inhibition of succinate dehydrogenase with macrophage metabolic remodeling and regulation of Inflammation. Cell Metab. 24, 158–166 (2016).
doi: 10.1016/j.cmet.2016.06.004
Liao, S. T. et al. 4-Octyl itaconate inhibits aerobic glycolysis by targeting GAPDH to exert anti-inflammatory effects. Nat. Commun. 10, 5091 (2019).
doi: 10.1038/s41467-019-13078-5
Qin, W. et al. S-glycosylation-based cysteine profiling reveals regulation of glycolysis by itaconate. Nat. Chem. Biol. 15, 983–991 (2019).
doi: 10.1038/s41589-019-0323-5
ElAzzouny, M. et al. Dimethyl itaconate is not metabolized into itaconate intracellularly. J. Biol. Chem. 292, 4766–4769 (2017).
doi: 10.1074/jbc.C117.775270
Swain, A. et al. Comparative evaluation of itaconate and its derivatives reveals divergent inflammasome and type I interferon regulation in macrophages. Nat. Metab. 2, 594–602 (2020).
doi: 10.1038/s42255-020-0210-0
Bambouskova, M. et al. Itaconate confers tolerance to late NLRP3 inflammasome activation. Cell Rep. 34, 108756 (2021).
doi: 10.1016/j.celrep.2021.108756
Ghosn, E. E. et al. Two physically, functionally, and developmentally distinct peritoneal macrophage subsets. Proc. Natl Acad. Sci. USA 107, 2568–2573 (2010).
doi: 10.1073/pnas.0915000107
Wang, J. & Zhang, K. Production of mesaconate in Escherichia coli by engineered glutamate mutase pathway. Metab. Eng. 30, 190–196 (2015).
doi: 10.1016/j.ymben.2015.06.001
Meiser, J. et al. Pro-inflammatory macrophages sustain pyruvate oxidation through pyruvate dehydrogenase for the synthesis of itaconate and to enable cytokine expression. J. Biol. Chem. 291, 3932–3946 (2016).
doi: 10.1074/jbc.M115.676817
Hooftman, A. et al. The immunomodulatory metabolite itaconate modifies NLRP3 and inhibits inflammasome activation. Cell Metab. 32, 468–478 (2020).
doi: 10.1016/j.cmet.2020.07.016
Broz, P. & Dixit, V. M. Inflammasomes: mechanism of assembly, regulation and signalling. Nat. Rev. Immunol. 16, 407–420 (2016).
doi: 10.1038/nri.2016.58
Mangan, M. S. J. et al. Targeting the NLRP3 inflammasome in inflammatory diseases. Nat. Rev. Drug Disco. 17, 688 (2018).
doi: 10.1038/nrd.2018.149
Chen, F. et al. Citraconate inhibits ACOD1 (IRG1) catalysis, reduces interferon responses and oxidative stress, and modulates inflammation and cell metabolism. Nat. Metab.
Kornberg, M. D. et al. Dimethyl fumarate targets GAPDH and aerobic glycolysis to modulate immunity. Science 360, 449–453 (2018).
doi: 10.1126/science.aan4665
Montes Diaz, G., Hupperts, R., Fraussen, J. & Somers, V. Dimethyl fumarate treatment in multiple sclerosis: recent advances in clinical and immunological studies. Autoimmun. Rev. 17, 1240–1250 (2018).
doi: 10.1016/j.autrev.2018.07.001
Hartman, M. G. et al. Role for activating transcription factor 3 in stress-induced beta-cell apoptosis. Mol. Cell. Biol. 24, 5721–5732 (2004).
doi: 10.1128/MCB.24.13.5721-5732.2004
Chen, Y. et al. Hepatocyte-specific Gclc deletion leads to rapid onset of steatosis with mitochondrial injury and liver failure. Hepatology 45, 1118–1128 (2007).
doi: 10.1002/hep.21635
Clausen, B. E., Burkhardt, C., Reith, W., Renkawitz, R. & Forster, I. Conditional gene targeting in macrophages and granulocytes using LysMcre mice. Transgenic Res. 8, 265–277 (1999).
doi: 10.1023/A:1008942828960
Weindl, D. et al. Bridging the gap between non-targeted stable isotope labeling and metabolic flux analysis. Cancer Metab. 4, 10 (2016).
doi: 10.1186/s40170-016-0150-z
Sapcariu, S. C. et al. Simultaneous extraction of proteins and metabolites from cells in culture. MethodsX 1, 74–80 (2014).
doi: 10.1016/j.mex.2014.07.002
He, W. et al. TLR4 triggered complex inflammation in human pancreatic islets. Biochim. Biophys. Acta Mol. Basis Dis. 1865, 86–97 (2019).
doi: 10.1016/j.bbadis.2018.09.030
Battello, N. et al. The role of HIF-1 in oncostatin M-dependent metabolic reprogramming of hepatic cells. Cancer Metab. 4, 3 (2016).
doi: 10.1186/s40170-016-0141-0
Hiller, K. et al. MetaboliteDetector: comprehensive analysis tool for targeted and nontargeted GC/MS based metabolome analysis. Anal. Chem. 81, 3429–3439 (2009).
doi: 10.1021/ac802689c
Nonnenmacher, Y. et al. Analysis of mitochondrial metabolism in situ: combining stable isotope labeling with selective permeabilization. Metab. Eng. 43, 147–155 (2017).
doi: 10.1016/j.ymben.2016.12.005
Nonnenmacher, Y., Palorini, R. & Hiller, K. Determining compartment-specific metabolic fluxes. Methods Mol. Biol. 1862, 137–149 (2019).
doi: 10.1007/978-1-4939-8769-6_10
Afgan, E. et al. The Galaxy platform for accessible, reproducible and collaborative biomedical analyses: 2018 update. Nucleic Acids Res. 46, W537–W544 (2018).
doi: 10.1093/nar/gky379
Kim, D., Langmead, B. & Salzberg, S. L. HISAT: a fast spliced aligner with low memory requirements. Nat. Methods 12, 357–360 (2015).
doi: 10.1038/nmeth.3317
Robinson, M. D., McCarthy, D. J. & Smyth, G. K. edgeR: a Bioconductor package for differential expression analysis of digital gene expression data. Bioinformatics 26, 139–140 (2010).
doi: 10.1093/bioinformatics/btp616
Yu, G., Wang, L. G., Han, Y. & He, Q. Y. clusterProfiler: an R package for comparing biological themes among gene clusters. OMICS 16, 284–287 (2012).
doi: 10.1089/omi.2011.0118

Auteurs

Wei He (W)

Department of Bioinformatics and Biochemistry, Braunschweig Integrated Centre of Systems Biology (BRICS), Technische Universität Braunschweig, Braunschweig, Germany.

Antonia Henne (A)

Department of Bioinformatics and Biochemistry, Braunschweig Integrated Centre of Systems Biology (BRICS), Technische Universität Braunschweig, Braunschweig, Germany.
ORCID: 0000-0001-6870-5312

Mario Lauterbach (M)

Institute of Innate Immunity, University Hospital Bonn, University of Bonn, Bonn, Germany.

Eike Geißmar (E)

Institute of Innate Immunity, University Hospital Bonn, University of Bonn, Bonn, Germany.

Fabian Nikolka (F)

Department of Bioinformatics and Biochemistry, Braunschweig Integrated Centre of Systems Biology (BRICS), Technische Universität Braunschweig, Braunschweig, Germany.

Celia Kho (C)

Institute of Experimental Immunology, University Hospital Bonn, University of Bonn, Bonn, Germany.

Alexander Heinz (A)

Department of Bioinformatics and Biochemistry, Braunschweig Integrated Centre of Systems Biology (BRICS), Technische Universität Braunschweig, Braunschweig, Germany.

Catherine Dostert (C)

Experimental and Molecular Immunology, Department of Infection and Immunity, Luxembourg Institute of Health, Esch-sur-Alzette, Luxembourg.
Immunology and Genetics, Luxembourg Centre for System Biomedicine (LCSB), University of Luxembourg, Belval, Luxembourg.

Melanie Grusdat (M)

Experimental and Molecular Immunology, Department of Infection and Immunity, Luxembourg Institute of Health, Esch-sur-Alzette, Luxembourg.
Immunology and Genetics, Luxembourg Centre for System Biomedicine (LCSB), University of Luxembourg, Belval, Luxembourg.

Thekla Cordes (T)

Department of Bioinformatics and Biochemistry, Braunschweig Integrated Centre of Systems Biology (BRICS), Technische Universität Braunschweig, Braunschweig, Germany.
Department of Bioengineering, University of California, San Diego, La Jolla, CA, USA.
Molecular and Cell Biology Laboratory, Salk Institute for Biological Studies, La Jolla, CA, USA.

Janika Härm (J)

Department of Bioinformatics and Biochemistry, Braunschweig Integrated Centre of Systems Biology (BRICS), Technische Universität Braunschweig, Braunschweig, Germany.
Experimental and Molecular Immunology, Department of Infection and Immunity, Luxembourg Institute of Health, Esch-sur-Alzette, Luxembourg.
Immunology and Genetics, Luxembourg Centre for System Biomedicine (LCSB), University of Luxembourg, Belval, Luxembourg.

Oliver Goldmann (O)

Infection Immunology Research Group, Helmholtz Centre for Infection Research, Braunschweig, Germany.

Anouk Ewen (A)

Experimental and Molecular Immunology, Department of Infection and Immunity, Luxembourg Institute of Health, Esch-sur-Alzette, Luxembourg.
Immunology and Genetics, Luxembourg Centre for System Biomedicine (LCSB), University of Luxembourg, Belval, Luxembourg.

Charlène Verschueren (C)

Experimental and Molecular Immunology, Department of Infection and Immunity, Luxembourg Institute of Health, Esch-sur-Alzette, Luxembourg.
Immunology and Genetics, Luxembourg Centre for System Biomedicine (LCSB), University of Luxembourg, Belval, Luxembourg.

Julia Blay-Cadanet (J)

Department of Biomedicine, Aarhus University, Aarhus, Denmark.

Robert Geffers (R)

Genome Analytics, Helmholtz Centre for Infection Research, Braunschweig, Germany.
ORCID: 0000-0003-4409-016X

Hendrikus Garritsen (H)

Institute of Transfusion Medicine, Klinikum Braunschweig, Braunschweig, Germany.
Fraunhofer Institute for Surface Engineering and Thin Films IST, Braunschweig, Germany.

Manfred Kneiling (M)

Department of Dermatology, Eberhard Karls University, Tübingen, Germany.
Werner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, Eberhard Karls University, Tübingen, Germany.

Christian K Holm (CK)

Department of Biomedicine, Aarhus University, Aarhus, Denmark.
ORCID: 0000-0002-2655-3362

Christian M Metallo (CM)

Department of Bioengineering, University of California, San Diego, La Jolla, CA, USA.
Molecular and Cell Biology Laboratory, Salk Institute for Biological Studies, La Jolla, CA, USA.
ORCID: 0000-0003-2404-3040

Eva Medina (E)

Infection Immunology Research Group, Helmholtz Centre for Infection Research, Braunschweig, Germany.

Zeinab Abdullah (Z)

Institute of Experimental Immunology, University Hospital Bonn, University of Bonn, Bonn, Germany.
Department of Immunology, Tehran University of Medical Sciences, Tehran, Iran.

Eicke Latz (E)

Institute of Innate Immunity, University Hospital Bonn, University of Bonn, Bonn, Germany.
German Center for Neurodegenerative Diseases, Bonn, Germany.
Department of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, MA, USA.
Centre of Molecular Inflammation Research, Norwegian University of Science and Technology, Trondheim, Norway.
ORCID: 0000-0003-1488-5666

Dirk Brenner (D)

Experimental and Molecular Immunology, Department of Infection and Immunity, Luxembourg Institute of Health, Esch-sur-Alzette, Luxembourg.
Immunology and Genetics, Luxembourg Centre for System Biomedicine (LCSB), University of Luxembourg, Belval, Luxembourg.
Odense Research Center for Anaphylaxis, Department of Dermatology and Allergy Center, Odense University Hospital, University of Southern Denmark, Odense, Denmark.
ORCID: 0000-0001-8979-1045

Karsten Hiller (K)

Department of Bioinformatics and Biochemistry, Braunschweig Integrated Centre of Systems Biology (BRICS), Technische Universität Braunschweig, Braunschweig, Germany. karsten.hiller@tu-braunschweig.de.
ORCID: 0000-0001-9322-5820

Articles similaires

Evaluating the efficacy of telesurgery with dual console SSI Mantra Surgical Robotic System: experiment on animal model and clinical trials.

Sudhir Prem Srivastava, Vishwajyoti Pascual Srivastava, Avinesh Singh et al.
1.00
Robotic Surgical Procedures Animals Humans Telemedicine Models, Animal

Odour generalisation and detection dog training.

Lyn Caldicott, Thomas W Pike, Helen E Zulch et al.
1.00
Animals Odorants Dogs Generalization, Psychological Smell

FBXO22 inhibits colitis and colorectal carcinogenesis by regulating the degradation of the S2448-phosphorylated form of mTOR.

Minle Li, Xuan Chen, Pengfei Qu et al.
1.00
Animals TOR Serine-Threonine Kinases Colorectal Neoplasms Colitis Mice

Use of organic material provided by an automatic enrichment device by weaner pigs and its influence on tail lesions.

Philipp Heseker, Jeanette Probst, Stefanie Ammer et al.
1.00
Animals Tail Swine Behavior, Animal Animal Husbandry

Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Mesaconate is synthesized from itaconate and...
questionsmedicales.fr › Structures macromoléculaires › Complexes multiprotéiques › Inflammasomes › Mesaconate is synthesized from itaconate and...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Phagocytes › Macrophages › Mesaconate is synthesized from itaconate and...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Mesaconate is synthesized from itaconate and...
questionsmedicales.fr › Cellules › Cellules RAW 264.7 › Mesaconate is synthesized from itaconate and...
questionsmedicales.fr › Composés chimiques organiques › Acides carboxyliques › Acides acycliques › Diacides carboxyliques › Succinates › Mesaconate is synthesized from itaconate and...