Circulating S-Glutathionylated cMyBP-C as a Biomarker for Cardiac Diastolic Dysfunction.
S‐glutathionylation
cMyBP‐C
diastolic dysfunction
Journal
Journal of the American Heart Association
ISSN: 2047-9980
Titre abrégé: J Am Heart Assoc
Pays: England
ID NLM: 101580524
Informations de publication
Date de publication:
07 06 2022
07 06 2022
Historique:
pubmed:
4
6
2022
medline:
18
6
2022
entrez:
3
6
2022
Statut:
ppublish
Résumé
Background cMyBP-C (Cardiac myosin binding protein-C) regulates cardiac contraction and relaxation. Previously, we demonstrated that elevated myocardial S-glutathionylation of cMyBP-C correlates with diastolic dysfunction (DD) in animal models. In this study, we tested whether circulating S-glutathionylated cMyBP-C would be a biomarker for DD. Methods and Results Humans, African Green monkeys, and mice had DD determined by echocardiography. Blood samples were acquired and analyzed for S-glutathionylated cMyBP-C by immunoprecipitation. Circulating S-glutathionylated cMyBP-C in human participants with DD (n=24) was elevated (1.46±0.13-fold,
Identifiants
pubmed: 35656993
doi: 10.1161/JAHA.122.025295
pmc: PMC9238749
doi:
Substances chimiques
Biomarkers
0
Carrier Proteins
0
myosin-binding protein C
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
e025295Subventions
Organisme : NIH HHS
ID : P40 OD010965
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL106592
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL085520
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL104025
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001420
Pays : United States
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