Mortality in cancer patients with SARS-CoV-2 or seasonal influenza: an observational cohort study from a German-wide hospital network.
COVID-19
Cancer
Mortality
SARS-CoV-2
Seasonal influenza
Vaccination
Journal
Infection
ISSN: 1439-0973
Titre abrégé: Infection
Pays: Germany
ID NLM: 0365307
Informations de publication
Date de publication:
Feb 2023
Feb 2023
Historique:
received:
20
02
2022
accepted:
07
05
2022
pubmed:
4
6
2022
medline:
31
1
2023
entrez:
3
6
2022
Statut:
ppublish
Résumé
At the beginning of the COVID-19 pandemic, SARS-CoV-2 was often compared to seasonal influenza. We aimed to compare the outcome of hospitalized patients with cancer infected by SARS-CoV-2 or seasonal influenza including intensive care unit admission, mechanical ventilation and in-hospital mortality. We analyzed claims data of patients with a lab-confirmed SARS-CoV-2 or seasonal influenza infection admitted to one of 85 hospitals of a German-wide hospital network between January 2016 and August 2021. 29,284 patients with COVID-19 and 7442 patients with seasonal influenza were included. Of these, 360 patients with seasonal influenza and 1625 patients with COVID-19 had any kind of cancer. Cancer patients with COVID-19 were more likely to be admitted to the intensive care unit than cancer patients with seasonal influenza (29.4% vs 24.7%; OR 1.31, 95% CI 1.00-1.73 p < .05). No statistical significance was observed in the mechanical ventilation rate for cancer patients with COVID-19 compared to those with seasonal influenza (17.2% vs 13.6% OR 1.34, 95% CI 0.96-1.86 p = .09). 34.9% of cancer patients with COVID-19 and 17.9% with seasonal influenza died (OR 2.45, 95% CI 1.81-3.32 p < .01). Risk factors among cancer patients with COVID-19 or seasonal influenza for in-hospital mortality included the male gender, age, a higher Elixhauser comorbidity index and metastatic cancer. Among cancer patients, SARS-CoV-2 was associated with a higher risk for in-hospital mortality than seasonal influenza. These findings underline the need of protective measurements to prevent an infection with either COVID-19 or seasonal influenza, especially in this high-risk population.
Identifiants
pubmed: 35657531
doi: 10.1007/s15010-022-01852-5
pii: 10.1007/s15010-022-01852-5
pmc: PMC9163872
doi:
Types de publication
Observational Study
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
119-127Informations de copyright
© 2022. The Author(s).
Références
Piroth L, et al. Comparison of the characteristics, morbidity, and mortality of COVID-19 and seasonal influenza: a nationwide, population-based retrospective cohort study. Lancet Respir Med. 2021;9:251–9.
doi: 10.1016/S2213-2600(20)30527-0
ElGohary GM et al. The risk and prognosis of COVID-19 infection in cancer patients: a systematic review and meta-analysis. Hematol Oncol Stem Cell Ther. 2020. https://doi.org/10.1016/j.hemonc.2020.07.005
doi: 10.1016/j.hemonc.2020.07.005
Auvinen R, et al. Comparison of the clinical characteristics and outcomes of hospitalized adult COVID-19 and influenza patients—a prospective observational study. Infect Dis. 2021;53:111–21.
doi: 10.1080/23744235.2020.1840623
Rüthrich MM, et al. COVID-19 in cancer patients: clinical characteristics and outcome—an analysis of the LEOSS registry. Ann Hematol. 2021;100:383–93.
doi: 10.1007/s00277-020-04328-4
Collins JP, et al. Outcomes of immunocompromised adults hospitalized with laboratory-confirmed influenza in the United States, 2011–2015. Clin Infect Dis. 2020;70:2121–30.
doi: 10.1093/cid/ciz638
Memoli MJ, et al. The natural history of influenza infection in the severely immunocompromised vs nonimmunocompromised hosts. Clin Infect Dis. 2014;58:214–24.
doi: 10.1093/cid/cit725
Rieck T, et al. Impfquoten bei Erwachsenen in Deutschland—Aktuelles aus der KV-Impfsurveillance und der Onlinebefragung von Krankenhauspersonal. OKaPII. 2020;47:3–26.
Brehm TT, et al. Comparison of clinical characteristics and disease outcome of COVID-19 and seasonal influenza. Sci Rep. 2021;11:1–10.
doi: 10.1038/s41598-021-85081-0
Meschiari M, et al. First and second waves among hospitalised patients with COVID-19 with severe pneumonia: a comparison of 28-day mortality over the 1-year pandemic in a tertiary university hospital in Italy. BMJ Open. 2022;12: e054069.
doi: 10.1136/bmjopen-2021-054069
Greene SK, et al. Reduced COVID-19 hospitalizations among New York City residents following age-based SARS-CoV-2 vaccine eligibility: Evidence from a regression discontinuity design. Vaccine. 2022;10:100134.
Burn E, et al. Deep phenotyping of 34,128 adult patients hospitalised with COVID-19 in an international network study. Nat Commun. 2020;11:1–11.
doi: 10.1038/s41467-020-18849-z
Zayet S, et al. Clinical features of COVID-19 and influenza: a comparative study on nord franche-comte cluster. Microbes Infect. 2020;22:481–8.
doi: 10.1016/j.micinf.2020.05.016
Lambermont B, et al. Outcome improvement between the first two waves of the coronavirus disease 2019 pandemic in a single tertiary-care hospital in Belgium. Crit Care Explor. 2021;3(5):e0438.
doi: 10.1097/CCE.0000000000000438
Dai M, et al. Patients with cancer appear more vulnerable to SARS-CoV-2: a multicenter study during the COVID-19 outbreak. Cancer Discov. 2020;10:783–91.
doi: 10.1158/2159-8290.CD-20-0422
Gosain R, et al. COVID-19 and cancer: a comprehensive review. Curr Oncol Rep. 2020;22:1–15.
doi: 10.1007/s11912-020-00934-7
Mauvais-Jarvis F. Aging, male sex, obesity, and metabolic inflammation create the perfect storm for COVID-19. Diabetes. 2020;69:1857–63.
doi: 10.2337/dbi19-0023
Michalakis K, Ilias I. SARS-CoV-2 infection and obesity: Common inflammatory and metabolic aspects. Diabetes Metab Syndr. 2020;14(4):469–71.
doi: 10.1016/j.dsx.2020.04.033
Choudhary S, Sharma K, Silakari O. The interplay between inflammatory pathways and COVID-19: A critical review on pathogenesis and therapeutic options. Microb Pathog. 2021;150: 104673.
doi: 10.1016/j.micpath.2020.104673
Liang W, et al. Cancer patients in SARS-CoV-2 infection: a nationwide analysis in China. Lancet Oncol. 2020;21:335–7.
doi: 10.1016/S1470-2045(20)30096-6
Bernard A, et al. Comparison of cancer patients to non-cancer patients among covid-19 inpatients at a national level. Cancers. 2021;13:1436.
doi: 10.3390/cancers13061436
Ángeles-Sistac D, et al. Influenza in patients with cancer after 2009 pandemic AH1N1: an 8-year follow-up study in Mexico. Influenza Other Respir Viruses. 2020;14:196–203.
doi: 10.1111/irv.12704
Kuderer NM, et al. Clinical impact of COVID-19 on patients with cancer (CCC19): a cohort study. The Lancet. 2020;395:1907–18.
doi: 10.1016/S0140-6736(20)31187-9
Lee LY, et al. COVID-19 mortality in patients with cancer on chemotherapy or other anticancer treatments: a prospective cohort study. The Lancet. 2020;395:1919–26.
doi: 10.1016/S0140-6736(20)31173-9
Bauer J, et al. Access to intensive care in 14 European countries: a spatial analysis of intensive care need and capacity in the light of COVID-19. Intensive Care Med. 2020;46(11):2026–34.
doi: 10.1007/s00134-020-06229-6
Chavez-MacGregor M, et al. Evaluation of COVID-19 mortality and adverse outcomes in US patients with or without cancer. JAMA Oncol. 2022;8(1):69–78.
doi: 10.1001/jamaoncol.2021.5148
Sharafeldin N, et al. Outcomes of COVID-19 in patients with cancer: report from the national COVID cohort collaborative (N3C). J Clin Oncol 2021: JCO. 21.01074.
Cooksley CD, et al. Epidemiology and outcomes of serious influenza-related infections in the cancer population cancer: Interdisciplinary. Int J Am Cancer Soc. 2005;104:618–28.
Yang F, et al. Clinical characteristics and outcomes of cancer patients with COVID-19. J Med Virol. 2020;92:2067–73.
doi: 10.1002/jmv.25972
Li J, et al. Influenza in hospitalised patients with malignancy: a propensity score matching analysis. ESMO open. 2020;5:e000968.
doi: 10.1136/esmoopen-2020-000968
Diebold M, et al. Temporal trends of COVID-19 related in-hospital mortality and demographics in Switzerland—a retrospective single centre cohort study. Swiss Med Wkly 2021;151:w20572.
doi: 10.4414/smw.2021.20572
https://www.destatis.de/DE/Themen/Querschnitt/Corona/Gesellschaft/bevoelkerung-sterbefaelle.html Statistisches Bundesamt, accessed on 14 Nov 2021.
Cabezas C, et al. Associations of BNT162b2 vaccination with SARS-CoV-2 infection and hospital admission and death with covid-19 in nursing homes and healthcare workers in Catalonia: prospective cohort study. bmj 2021;374:n1868. https://doi.org/10.1136/bmj.n1868 .
doi: 10.1136/bmj.n1868
Rinott E, Youngster I, Lewis YE. Reduction in COVID-19 patients requiring mechanical ventilation following implementation of a national COVID-19 vaccination program—Israel, December 2020–February 2021. Morb Mortal Wkly Rep. 2021;70:326.
doi: 10.15585/mmwr.mm7009e3