Gastroprotective effect of vitamin U in D-galactosamine-induced hepatotoxicity.
Adenosine Triphosphatases
/ metabolism
Animals
Antioxidants
/ metabolism
Catalase
/ metabolism
Chemical and Drug Induced Liver Injury
/ prevention & control
Fucose
/ pharmacology
Galactosamine
/ toxicity
Glutathione
/ metabolism
Glutathione Peroxidase
/ metabolism
Glutathione Reductase
/ metabolism
Glutathione Transferase
/ metabolism
Lactate Dehydrogenases
/ metabolism
Lipid Peroxidation
N-Acetylneuraminic Acid
/ pharmacology
Oxidative Stress
Peroxidase
/ metabolism
Rats
Reactive Oxygen Species
Superoxide Dismutase
/ metabolism
Vitamin U
/ pharmacology
Xanthine Oxidase
/ metabolism
galactosamine
oxidative stress
protective effect
stomach
vitamin U
Journal
Journal of biochemical and molecular toxicology
ISSN: 1099-0461
Titre abrégé: J Biochem Mol Toxicol
Pays: United States
ID NLM: 9717231
Informations de publication
Date de publication:
Sep 2022
Sep 2022
Historique:
revised:
12
04
2022
received:
05
08
2021
accepted:
29
05
2022
pubmed:
8
6
2022
medline:
20
9
2022
entrez:
7
6
2022
Statut:
ppublish
Résumé
Galactosamine (GalN) is a well-known agent for inducing viral hepatitis models in rodents, but it can cause toxicity on different organs. Vitamin U (Vit U) has been proved as a powerful antioxidant on many toxicity models. The present study was designed to investigate the protective effects of Vit U on GalN-induced stomach injury. Rats were divided into four groups as follows: control (group I), Vit U given animals (50 mg/kg per day; group II), GalN administered animals (500 mg/kg at a single dose; group III), GalN + Vit U given animals (at the same dose and time, group IV). At the end of the 3rd day, animals were killed, and stomach tissues were taken. They were homogenized and centrifuged. In comparison to the control group, glutathione, total antioxidant capacity levels, catalase, superoxide dismutase, glutathione peroxidase, glutathione reductase, glutathione-S-transferase, and Na
Substances chimiques
Antioxidants
0
Reactive Oxygen Species
0
Fucose
28RYY2IV3F
Vitamin U
3485Y39925
Galactosamine
7535-00-4
Lactate Dehydrogenases
EC 1.1.-
Catalase
EC 1.11.1.6
Peroxidase
EC 1.11.1.7
Glutathione Peroxidase
EC 1.11.1.9
Superoxide Dismutase
EC 1.15.1.1
Xanthine Oxidase
EC 1.17.3.2
Glutathione Reductase
EC 1.8.1.7
Glutathione Transferase
EC 2.5.1.18
Adenosine Triphosphatases
EC 3.6.1.-
Glutathione
GAN16C9B8O
N-Acetylneuraminic Acid
GZP2782OP0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e23124Informations de copyright
© 2022 Wiley Periodicals LLC.
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