Recent advances in understanding the role of HES6 in cancers.
HES6
NOTCH
cancers
signaling
uveal melanoma
Journal
Theranostics
ISSN: 1838-7640
Titre abrégé: Theranostics
Pays: Australia
ID NLM: 101552395
Informations de publication
Date de publication:
2022
2022
Historique:
received:
17
03
2022
accepted:
06
05
2022
entrez:
8
6
2022
pubmed:
9
6
2022
medline:
10
6
2022
Statut:
epublish
Résumé
The NOTCH signaling system regulates a variety of cellular processes during embryonic development and homeostasis maintenance in different tissues and contexts. Hence, dysregulation of NOTCH signaling is associated with a plethora of human cancers, and there have been multiple efforts to target key components of this pathway. In this review, we briefly highlight the latest research advances in understanding HES6, a poorly studied component of the NOTCH pathway. We summarize the role of HES6 in cancers with a focus on uveal melanoma. Finally, we discuss the ongoing efforts to target the NOTCH-HES6 axis in cancers.
Identifiants
pubmed: 35673577
doi: 10.7150/thno.72966
pii: thnov12p4374
pmc: PMC9169368
doi:
Substances chimiques
Basic Helix-Loop-Helix Transcription Factors
0
HES6 protein, human
0
Repressor Proteins
0
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
4374-4385Informations de copyright
© The author(s).
Déclaration de conflit d'intérêts
Competing Interests: The authors have declared that no competing interest exists.
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