Same-Day Compared With Overnight Cervical Preparation Before Dilation and Evacuation Between 16 and 19 6/7 Weeks of Gestation: A Randomized Controlled Trial.
Journal
Obstetrics and gynecology
ISSN: 1873-233X
Titre abrégé: Obstet Gynecol
Pays: United States
ID NLM: 0401101
Informations de publication
Date de publication:
01 06 2022
01 06 2022
Historique:
received:
14
12
2021
accepted:
24
02
2022
entrez:
8
6
2022
pubmed:
9
6
2022
medline:
11
6
2022
Statut:
ppublish
Résumé
We performed a double-blind, placebo-controlled, randomized noninferiority trial to compare same-day osmotic dilators plus misoprostol with overnight osmotic dilators alone for cervical preparation before dilation and evacuation (D&E) between 16 0/7 and 19 6/7 weeks of gestation. The primary outcome was procedure time. The study was halted early owing to poor accrual. However, the median procedure time was 5.7 minutes in the same-day group compared with 4.2 minutes in the overnight group. The median absolute difference in procedure time was 1.5 minutes, which corresponded to a 35% increase in procedure time (relative difference 35%, one-sided 95% CI -Inf to 52%). Same-day cervical preparation with osmotic dilators plus buccal misoprostol before D&E may be a timely option. Clinical Trial Registration: ClinicalTrials.gov, NCT03002441.
Identifiants
pubmed: 35675611
doi: 10.1097/AOG.0000000000004790
pii: 00006250-202206000-00020
doi:
Substances chimiques
Abortifacient Agents, Nonsteroidal
0
Misoprostol
0E43V0BB57
Banques de données
ClinicalTrials.gov
['NCT03002441']
Types de publication
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Letter
Langues
eng
Sous-ensembles de citation
IM
Pagination
1141-1144Commentaires et corrections
Type : ErratumIn
Informations de copyright
Copyright © 2022 by the American College of Obstetricians and Gynecologists. Published by Wolters Kluwer Health, Inc. All rights reserved.
Références
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