ATGL is a biosynthetic enzyme for fatty acid esters of hydroxy fatty acids.
Journal
Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462
Informations de publication
Date de publication:
06 2022
06 2022
Historique:
received:
30
04
2021
accepted:
21
04
2022
pubmed:
9
6
2022
medline:
2
7
2022
entrez:
8
6
2022
Statut:
ppublish
Résumé
Branched fatty acid (FA) esters of hydroxy FAs (HFAs; FAHFAs) are recently discovered lipids that are conserved from yeast to mammals
Identifiants
pubmed: 35676490
doi: 10.1038/s41586-022-04787-x
pii: 10.1038/s41586-022-04787-x
pmc: PMC9242854
doi:
Substances chimiques
Diglycerides
0
Esters
0
Fatty Acids
0
Hydroxy Acids
0
Triglycerides
0
Acyltransferases
EC 2.3.-
PNPLA2 protein, human
EC 3.1.1.3
PNPLA2 protein, mouse
EC 3.1.1.3
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
968-975Subventions
Organisme : NIH HHS
ID : S10 OD021815
Pays : United States
Organisme : NIDDK NIH HHS
ID : F30 DK112622
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK106210
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK046200
Pays : United States
Organisme : NIDDK NIH HHS
ID : K01 DK128075
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK057521
Pays : United States
Organisme : NIDDK NIH HHS
ID : R56 DK043051
Pays : United States
Organisme : NIDDK NIH HHS
ID : T32 DK007516
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA014195
Pays : United States
Organisme : NHLBI NIH HHS
ID : T32 HL007374
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK043051
Pays : United States
Informations de copyright
© 2022. The Author(s).
Références
Yore, M. M. et al. Discovery of a class of endogenous mammalian lipids with anti-diabetic and anti-inflammatory effects. Cell 159, 318–332 (2014).
pubmed: 25303528
pmcid: 4260972
doi: 10.1016/j.cell.2014.09.035
Celis Ramirez, A. M. et al. Analysis of Malassezia lipidome disclosed differences among the species and reveals presence of unusual yeast lipids. Front. Cell. Infect. Microbiol. 10, 338 (2020).
pubmed: 32760678
pmcid: 7374198
doi: 10.3389/fcimb.2020.00338
Brejchova, K. et al. Understanding FAHFAs: from structure to metabolic regulation. Prog. Lipid Res. 79, 101053 (2020).
pubmed: 32735891
doi: 10.1016/j.plipres.2020.101053
Lee, J. et al. Branched fatty acid esters of hydroxy fatty acids (FAHFAs) protect against colitis by regulating gut innate and adaptive immune responses. J. Biol. Chem. 291, 22207–22217 (2016).
pubmed: 27573241
pmcid: 5064000
doi: 10.1074/jbc.M115.703835
Syed, I. et al. Palmitic acid hydroxystearic acids activate GPR40, which is involved in their beneficial effects on glucose homeostasis. Cell Metab. 27, 419–427 (2018).
pubmed: 29414687
pmcid: 5807007
doi: 10.1016/j.cmet.2018.01.001
Syed, I. et al. PAHSAs attenuate immune responses and promote beta cell survival in autoimmune diabetic mice. J. Clin. Invest. 129, 3717–3731 (2019).
pubmed: 31380811
pmcid: 6715391
doi: 10.1172/JCI122445
Zhou, P. et al. PAHSAs enhance hepatic and systemic insulin sensitivity through direct and indirect mechanisms. J. Clin. Invest. 129, 4138–4150 (2019).
pubmed: 31449056
pmcid: 6763232
doi: 10.1172/JCI127092
Zhu, Q. F., Yan, J. W., Ni, J. & Feng, Y. Q. FAHFA footprint in the visceral fat of mice across their lifespan. Biochim. Biophys. Acta Mol. Cell Biol. Lipids 1865, 158639 (2020).
pubmed: 31988049
doi: 10.1016/j.bbalip.2020.158639
Brezinova, M. et al. Levels of palmitic acid ester of hydroxystearic acid (PAHSA) are reduced in the breast milk of obese mothers. Biochim. Biophys. Acta Mol. Cell Biol. Lipids 1863, 126–131 (2018).
pubmed: 29154942
doi: 10.1016/j.bbalip.2017.11.004
Zhu, Q. F. et al. Highly sensitive determination of fatty acid esters of hydroxyl fatty acids by liquid chromatography-mass spectrometry. J. Chromatogr. B 1061-1062, 34–40 (2017).
doi: 10.1016/j.jchromb.2017.06.045
Brezinova, M. et al. Exercise training induces insulin-sensitizing PAHSAs in adipose tissue of elderly women. Biochim. Biophys. Acta Mol. Cell Biol. Lipids 1865, 158576 (2020).
pubmed: 31740387
doi: 10.1016/j.bbalip.2019.158576
Dongoran, R. A. et al. Determination of major endogenous FAHFAs in healthy human circulation: the correlations with several circulating cardiovascular-related biomarkers and anti-inflammatory effects on RAW 264.7 cells. Biomolecules 10, 1689 (2020).
pmcid: 7766943
doi: 10.3390/biom10121689
Wen, X. H., Guo, Q. L. & Guo, J. C. Effect of 9-PAHSA on cognitive dysfunction in diabetic mice and its possible mechanism. Biochem. Biophys. Res. Commun. 524, 525–532 (2020).
pubmed: 32014256
doi: 10.1016/j.bbrc.2020.01.071
Kuda, O. et al. Docosahexaenoic acid-derived fatty acid esters of hydroxy fatty acids (FAHFAs) with anti-inflammatory properties. Diabetes 65, 2580–2590 (2016).
pubmed: 27313314
doi: 10.2337/db16-0385
Kolar, M. J. et al. Linoleic acid esters of hydroxy linoleic acids are anti-inflammatory lipids found in plants and mammals. J. Biol. Chem. 294, 10698–10707 (2019).
pubmed: 31152059
pmcid: 6615670
doi: 10.1074/jbc.RA118.006956
Benlebna, M. et al. Long-term intake of 9-PAHPA or 9-OAHPA modulates favorably the basal metabolism and exerts an insulin sensitizing effect in obesogenic diet-fed mice. Eur. J. Nutr. 60, 2013–2027 (2020).
pubmed: 32989473
doi: 10.1007/s00394-020-02391-1
Benlebna, M. et al. Long-term high intake of 9-PAHPA or 9-OAHPA increases basal metabolism and insulin sensitivity but disrupts liver homeostasis in healthy mice. J. Nutr. Biochem. 79, 108361 (2020).
pubmed: 32179409
doi: 10.1016/j.jnutbio.2020.108361
Kolar, M. J. et al. Branched fatty acid esters of hydroxy fatty acids are preferred substrates of the MODY8 protein carboxyl ester lipase. Biochemistry 55, 4636–4641 (2016).
pubmed: 27509211
doi: 10.1021/acs.biochem.6b00565
Parsons, W. H. et al. AIG1 and ADTRP are atypical integral membrane hydrolases that degrade bioactive FAHFAs. Nat. Chem. Biol. 12, 367–372 (2016).
pubmed: 27018888
pmcid: 4837090
doi: 10.1038/nchembio.2051
Brejchova, K. et al. Distinct roles of adipose triglyceride lipase and hormone-sensitive lipase in the catabolism of triacylglycerol estolides. Proc. Natl Acad. Sci. USA 118, e2020999118 (2021).
pubmed: 33372146
doi: 10.1073/pnas.2020999118
Kuda, O. et al. Nrf2-mediated antioxidant defense and peroxiredoxin 6 are linked to biosynthesis of palmitic acid ester of 9-hydroxystearic acid. Diabetes 67, 1190–1199 (2018).
pubmed: 29549163
pmcid: 6463562
doi: 10.2337/db17-1087
Bachovchin, D. A. et al. Superfamily-wide portrait of serine hydrolase inhibition achieved by library-versus-library screening. Proc. Natl Acad. Sci. USA 107, 20941–20946 (2010).
pubmed: 21084632
pmcid: 3000285
doi: 10.1073/pnas.1011663107
Liu, Y., Patricelli, M. P. & Cravatt, B. F. Activity-based protein profiling: the serine hydrolases. Proc. Natl Acad. Sci. USA 96, 14694–14699 (1999).
pubmed: 10611275
pmcid: 24710
doi: 10.1073/pnas.96.26.14694
Jessani, N. et al. A streamlined platform for high-content functional proteomics of primary human specimens. Nat. Methods 2, 691–697 (2005).
pubmed: 16118640
doi: 10.1038/nmeth778
Galmozzi, A., Dominguez, E., Cravatt, B. F. & Saez, E. Application of activity-based protein profiling to study enzyme function in adipocytes. Methods Enzymol. 538, 151–169 (2014).
pubmed: 24529438
pmcid: 4138146
doi: 10.1016/B978-0-12-800280-3.00009-8
Schreiber, R., Xie, H. & Schweiger, M. Of mice and men: the physiological role of adipose triglyceride lipase (ATGL). Biochim. Biophys. Acta Mol. Cell Biol. Lipids 1864, 880–899 (2019).
pubmed: 30367950
pmcid: 6439276
doi: 10.1016/j.bbalip.2018.10.008
Tan, D. et al. Discovery of FAHFA-containing triacylglycerols and their metabolic regulation. J. Am. Chem. Soc. 141, 8798–8806 (2019).
pubmed: 31056915
pmcid: 6662584
doi: 10.1021/jacs.9b00045
Paluchova, V. et al. Lipokine 5-PAHSA is regulated by adipose triglyceride lipase and primes adipocytes for de novo lipogenesis in mice. Diabetes 69, 300–312 (2020).
pubmed: 31806624
pmcid: 7118252
doi: 10.2337/db19-0494
Zimmermann, R. et al. Fat mobilization in adipose tissue is promoted by adipose triglyceride lipase. Science 306, 1383–1386 (2004).
pubmed: 15550674
doi: 10.1126/science.1100747
Jenkins, C. M. et al. Identification, cloning, expression, and purification of three novel human calcium-independent phospholipase A2 family members possessing triacylglycerol lipase and acylglycerol transacylase activities. J. Biol. Chem. 279, 48968–48975 (2004).
pubmed: 15364929
doi: 10.1074/jbc.M407841200
Villena, J. A., Roy, S., Sarkadi-Nagy, E., Kim, K. H. & Sul, H. S. Desnutrin, an adipocyte gene encoding a novel patatin domain-containing protein, is induced by fasting and glucocorticoids: ectopic expression of desnutrin increases triglyceride hydrolysis. J. Biol. Chem. 279, 47066–47075 (2004).
pubmed: 15337759
doi: 10.1074/jbc.M403855200
Taschler, U. et al. Adipose triglyceride lipase is involved in the mobilization of triglyceride and retinoid stores of hepatic stellate cells. Biochim. Biophys. Acta 1851, 937–945 (2015).
pubmed: 25732851
pmcid: 4408194
doi: 10.1016/j.bbalip.2015.02.017
Notari, L. et al. Identification of a lipase-linked cell membrane receptor for pigment epithelium-derived factor. J. Biol. Chem. 281, 38022–38037 (2006).
pubmed: 17032652
doi: 10.1074/jbc.M600353200
Zhang, X. et al. An epistatic interaction between Pnpla2 and Lipe reveals new pathways of adipose tissue lipolysis. Cells 8, 395 (2019).
pmcid: 6563012
doi: 10.3390/cells8050395
Ohno, Y., Kamiyama, N., Nakamichi, S. & Kihara, A. PNPLA1 is a transacylase essential for the generation of the skin barrier lipid ω-O-acylceramide. Nat. Commun. 8, 14610 (2017).
pubmed: 28248318
pmcid: 5337975
doi: 10.1038/ncomms14610
Grond, S. et al. PNPLA1 deficiency in mice and humans leads to a defect in the synthesis of omega-O-acylceramides. J. Invest. Dermatol. 137, 394–402 (2017).
pubmed: 27751867
doi: 10.1016/j.jid.2016.08.036
Lass, A. et al. Adipose triglyceride lipase-mediated lipolysis of cellular fat stores is activated by CGI-58 and defective in Chanarin-Dorfman Syndrome. Cell Metab. 3, 309–319 (2006).
pubmed: 16679289
doi: 10.1016/j.cmet.2006.03.005
Kulminskaya, N. et al. Optimized expression and purification of adipose triglyceride lipase improved hydrolytic and transacylation activities in vitro. J. Biol. Chem. 297, 101206 (2021).
pubmed: 34543623
pmcid: 8506970
doi: 10.1016/j.jbc.2021.101206
Schoiswohl, G. et al. Impact of reduced ATGL-mediated adipocyte lipolysis on obesity-associated insulin resistance and inflammation in male mice. Endocrinology 156, 3610–3624 (2015).
pubmed: 26196542
pmcid: 4588821
doi: 10.1210/en.2015-1322
Perry, R. J. et al. Hepatic acetyl CoA links adipose tissue inflammation to hepatic insulin resistance and type 2 diabetes. Cell 160, 745–758 (2015).
pubmed: 25662011
pmcid: 4498261
doi: 10.1016/j.cell.2015.01.012
Ahmadian, M. et al. Adipose overexpression of desnutrin promotes fatty acid use and attenuates diet-induced obesity. Diabetes 58, 855–866 (2009).
pubmed: 19136649
pmcid: 2661591
doi: 10.2337/db08-1644
Jocken, J. W. et al. Adipose triglyceride lipase and hormone-sensitive lipase protein expression is decreased in the obese insulin-resistant state. J. Clin. Endocrinol. Metab. 92, 2292–2299 (2007).
pubmed: 17356053
doi: 10.1210/jc.2006-1318
Nelson, A. T. et al. Stereochemistry of endogenous palmitic acid ester of 9-hydroxystearic acid and relevance of absolute configuration to regulation. J. Am. Chem. Soc. 139, 4943–4947 (2017).
pubmed: 28350171
pmcid: 5568760
doi: 10.1021/jacs.7b01269
Gruber, A. et al. The N-terminal region of comparative gene identification-58 (CGI-58) is important for lipid droplet binding and activation of adipose triglyceride lipase. J. Biol. Chem. 285, 12289–12298 (2010).
pubmed: 20164531
pmcid: 2852968
doi: 10.1074/jbc.M109.064469
Cornaciu, I. et al. The minimal domain of adipose triglyceride lipase (ATGL) ranges until leucine 254 and can be activated and inhibited by CGI-58 and G0S2, respectively. PLoS ONE 6, e26349 (2011).
pubmed: 22039468
pmcid: 3198459
doi: 10.1371/journal.pone.0026349
Cases, S. et al. Identification of a gene encoding an acyl CoA:diacylglycerol acyltransferase, a key enzyme in triacylglycerol synthesis. Proc. Natl Acad. Sci. USA 95, 13018–13023 (1998).
pubmed: 9789033
pmcid: 23692
doi: 10.1073/pnas.95.22.13018
Chitraju, C., Walther, T. C. & Farese, R. V. Jr The triglyceride synthesis enzymes DGAT1 and DGAT2 have distinct and overlapping functions in adipocytes. J. Lipid Res. 60, 1112–1120 (2019).
pubmed: 30936184
pmcid: 6547635
doi: 10.1194/jlr.M093112
Smith, S. J. et al. Obesity resistance and multiple mechanisms of triglyceride synthesis in mice lacking Dgat. Nat. Genet. 25, 87–90 (2000).
pubmed: 10802663
doi: 10.1038/75651
Lee, M. J. & Fried, S. K. Optimal protocol for the differentiation and metabolic analysis of human adipose stromal cells. Methods Enzymol. 538, 49–65 (2014).
pubmed: 24529433
pmcid: 4336794
doi: 10.1016/B978-0-12-800280-3.00004-9
Martin, B. R. & Cravatt, B. F. Large-scale profiling of protein palmitoylation in mammalian cells. Nat. Methods 6, 135–138 (2009).
pubmed: 19137006
pmcid: 2775068
doi: 10.1038/nmeth.1293
He, L., Diedrich, J., Chu, Y. Y. & Yates, J. R. 3rd Extracting accurate precursor information for tandem mass spectra by RawConverter. Anal. Chem. 87, 11361–11367 (2015).
pubmed: 26499134
pmcid: 4777630
doi: 10.1021/acs.analchem.5b02721
Xu, T. et al. ProLuCID: an improved SEQUEST-like algorithm with enhanced sensitivity and specificity. J. Proteomics 129, 16–24 (2015).
pubmed: 26171723
pmcid: 4630125
doi: 10.1016/j.jprot.2015.07.001
Tabb, D. L., McDonald, W. H. & Yates, J. R. 3rd DTASelect and Contrast: tools for assembling and comparing protein identifications from shotgun proteomics. J. Proteome Res. 1, 21–26 (2002).
pubmed: 12643522
pmcid: 2811961
doi: 10.1021/pr015504q
Peng, J., Elias, J. E., Thoreen, C. C., Licklider, L. J. & Gygi, S. P. Evaluation of multidimensional chromatography coupled with tandem mass spectrometry (LC/LC-MS/MS) for large-scale protein analysis: the yeast proteome. J. Proteome Res. 2, 43–50 (2003).
pubmed: 12643542
doi: 10.1021/pr025556v
Nagy, H. M. et al. Adipose triglyceride lipase activity is inhibited by long-chain acyl-coenzyme A. Biochim. Biophys. Acta 1841, 588–594 (2014).
pubmed: 24440819
pmcid: 3988850
doi: 10.1016/j.bbalip.2014.01.005
Shepherd, P. R. et al. Adipose cell hyperplasia and enhanced glucose disposal in transgenic mice overexpressing GLUT4 selectively in adipose tissue. J. Biol. Chem. 268, 22243–22246 (1993).
pubmed: 8226728
doi: 10.1016/S0021-9258(18)41516-5
Eguchi, J. et al. Transcriptional control of adipose lipid handling by IRF4. Cell Metab. 13, 249–259 (2011).
pubmed: 21356515
pmcid: 3063358
doi: 10.1016/j.cmet.2011.02.005
Bligh, E. G. & Dyer, W. J. A rapid method of total lipid extraction and purification. Can. J. Biochem. Physiol. 37, 911–917 (1959).
pubmed: 13671378
doi: 10.1139/y59-099
Zhang, T. et al. A LC-MS-based workflow for measurement of branched fatty acid esters of hydroxy fatty acids. Nat. Protoc. 11, 747–763 (2016).
pubmed: 26985573
pmcid: 4797065
doi: 10.1038/nprot.2016.040
Patel, R. et al. LXRbeta is required for glucocorticoid-induced hyperglycemia and hepatosteatosis in mice. J. Clin. Invest. 121, 431–441 (2011).
pubmed: 21123945
doi: 10.1172/JCI41681
Maclean, B. et al. Effect of collision energy optimization on the measurement of peptides by selected reaction monitoring (SRM) mass spectrometry. Anal. Chem. 82, 10116–10124 (2010).
pubmed: 21090646
pmcid: 3005404
doi: 10.1021/ac102179j