Sodium Acetate and Sodium Butyrate Differentially Upregulate Antimicrobial Component Production in Mammary Glands of Lactating Goats.
Antimicrobial components
Mammary glands
Ruminant
Short-chain fatty acids
Journal
Journal of mammary gland biology and neoplasia
ISSN: 1573-7039
Titre abrégé: J Mammary Gland Biol Neoplasia
Pays: United States
ID NLM: 9601804
Informations de publication
Date de publication:
06 2022
06 2022
Historique:
received:
25
01
2022
accepted:
11
05
2022
revised:
10
05
2022
pubmed:
10
6
2022
medline:
9
9
2022
entrez:
9
6
2022
Statut:
ppublish
Résumé
Short-chain fatty acids activate antimicrobial component production in the intestine. However, their effects on mammary glands remain unclear. We investigated the effects of acetate and butyrate on antimicrobial component production in mammary epithelial cells (MECs) or leukocytes cultured in vitro and in mammary glands of lactating Tokara goats in vivo. Our results showed that butyrate enhanced the production of β-defensin-1 and S100A7 in MECs. Additionally, the infusion of butyrate into mammary glands through the teats enhanced β-defensin-1 and S100A7 concentrations in milk. The infusion of acetate also increased β-defensin-1 and S100A7 concentrations along with those of cathelicidin-2 and interleukin-8, which are produced by leukocytes. Furthermore, acetate promoted cathelicidin-2 and interleukin-8 secretion in leukocytes in vitro. These findings suggest that acetate and butyrate differentially upregulate antimicrobial component production in mammary glands, which could help to develop appropriate treatment for mastitis, thereby reducing economic losses and improving animal welfare in farming environments.
Identifiants
pubmed: 35678903
doi: 10.1007/s10911-022-09519-5
pii: 10.1007/s10911-022-09519-5
doi:
Substances chimiques
Acetates
0
Anti-Bacterial Agents
0
Anti-Infective Agents
0
Interleukin-8
0
beta-Defensins
0
Butyric Acid
107-92-6
Sodium Acetate
4550K0SC9B
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
133-144Informations de copyright
© 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
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