Untapped Pharmaceutical Potential of 4,5,4'-Trihydroxy-3,3'-dimethoxybibenzyl for Regulating Obesity: A Cell-Based Study with a Focus on Terminal Differentiation in Adipogenesis.

3T3-L1 Cells Adipogenesis Animals Bibenzyls / pharmacology Cell Differentiation Dendrobium / chemistry Glycogen Synthase Kinase 3 beta Humans Mice Obesity / drug therapy

Journal

Journal of natural products
ISSN: 1520-6025
Titre abrégé: J Nat Prod
Pays: United States
ID NLM: 7906882

Informations de publication

Date de publication:
24 06 2022
Historique:
pubmed: 10 6 2022
medline: 28 6 2022
entrez: 9 6 2022
Statut: ppublish

Résumé

Obesity and its global prevalence has become a threat to human health, while its pharmacotherapy via the application of natural products is still underdeveloped. Here, we probed how 4,5,4'-trihydroxy-3,3'-dimethoxybibenzyl (TDB) derived from an orchid (

Identifiants

DOI: 10.1021/acs.jnatprod.2c00213 PMID: 35679136
pubmed: 35679136
doi: 10.1021/acs.jnatprod.2c00213
doi:

Substances chimiques

Bibenzyls 0
Glycogen Synthase Kinase 3 beta EC 2.7.11.1

Types de publication

Journal Article Review Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1591-1602

Commentaires et corrections

Type : ErratumIn

Auteurs

Hnin Ei Ei Khine (HEE)

Pharmaceutical Sciences and Technology Graduate Program, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand.
Department of Biochemistry and Microbiology, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand.

Rungroch Sungthong (R)

Department of Biochemistry and Microbiology, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand.
Institute of Biodiversity, Animal Health and Comparative Medicine, College of Medical Veterinary and Life Sciences, University of Glasgow, Glasgow G61 1QH, U.K.
ORCID: 0000-0002-5052-2611

Boonchoo Sritularak (B)

Department of Pharmacognosy and Pharmaceutical Botany, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand.
Center of Excellence in Natural Products for Ageing and Chronic Diseases, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand.

Eakachai Prompetchara (E)

Department of Biochemistry and Microbiology, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand.
Center of Excellence in Cancer Cell and Molecular Biology, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand.

Chatchai Chaotham (C)

Pharmaceutical Sciences and Technology Graduate Program, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand.
Center of Excellence in Cancer Cell and Molecular Biology, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand.
ORCID: 0000-0002-3206-192X

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Classifications MeSH

questionsmedicales.fr › Cellules › Cellules du tissu conjonctif › Fibroblastes › Cellules 3T3 › Cellules Swiss 3T3 › Cellules 3T3-L1 › Untapped Pharmaceutical Potential of...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Différenciation cellulaire › Adipogenèse › Untapped Pharmaceutical Potential of...
questionsmedicales.fr › Eucaryotes › Animaux › Untapped Pharmaceutical Potential of...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures cycliques › Hydrocarbures aromatiques › Dérivés du benzène › Composés benzyliques › Bibenzyles › Untapped Pharmaceutical Potential of...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Différenciation cellulaire › Untapped Pharmaceutical Potential of...
questionsmedicales.fr › Eucaryotes › Viridiplantae › Streptophyta › Embryophyta › Tracheobionta › Magnoliopsida › Lilianae › Asparagales › Orchidaceae › Dendrobium › Untapped Pharmaceutical Potential of...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protein-Serine-Threonine Kinases › Proline-directed protein kinases › Glycogen Synthase Kinase 3 › Glycogen synthase kinase 3 beta › Untapped Pharmaceutical Potential of...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Untapped Pharmaceutical Potential of...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Untapped Pharmaceutical Potential of...
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Obésité › Untapped Pharmaceutical Potential of...