Monoubiquitination in Homeostasis and Cancer.
cancer
homeostasis
monoubiquitination
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
25 May 2022
25 May 2022
Historique:
received:
25
04
2022
revised:
17
05
2022
accepted:
20
05
2022
entrez:
10
6
2022
pubmed:
11
6
2022
medline:
14
6
2022
Statut:
epublish
Résumé
Monoubiquitination is a post-translational modification (PTM), through which a single ubiquitin molecule is covalently conjugated to a lysine residue of the target protein. Monoubiquitination regulates the activity, subcellular localization, protein-protein interactions, or endocytosis of the substrate. In doing so, monoubiquitination is implicated in diverse cellular processes, including gene transcription, endocytosis, signal transduction, cell death, and DNA damage repair, which in turn regulate cell-cycle progression, survival, proliferation, and stress response. In this review, we summarize the functions of monoubiquitination and discuss how this PTM modulates homeostasis and cancer.
Identifiants
pubmed: 35682605
pii: ijms23115925
doi: 10.3390/ijms23115925
pmc: PMC9180643
pii:
doi:
Substances chimiques
Ubiquitin
0
Lysine
K3Z4F929H6
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NCI NIH HHS
ID : R01 CA166051
Pays : United States
Organisme : NIH HHS
ID : R01CA166051
Pays : United States
Organisme : Cancer Prevention and Research Institute of Texas
ID : RP190029
Organisme : National Natural Science Foundation of China
ID : 31900935
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