The Transcription Factor EB (TFEB) Sensitizes the Heart to Chronic Pressure Overload.

Animals Basic Helix-Loop-Helix Leucine Zipper Transcription Factors / metabolism Disease Models, Animal Echocardiography Heart Failure / metabolism Hypertrophy, Left Ventricular / pathology Male Mice Mice, Inbred C57BL Myocytes, Cardiac / metabolism Ventricular Dysfunction, Left / metabolism Ventricular Remodeling
heart failure left ventricular hypertrophy transcription factor EB

Journal

International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791

Informations de publication

Date de publication:
25 May 2022
Historique:
received: 30 04 2022
revised: 22 05 2022
accepted: 23 05 2022
entrez: 10 6 2022
pubmed: 11 6 2022
medline: 14 6 2022
Statut: epublish

Résumé

The transcription factor EB (TFEB) promotes protein degradation by the autophagy and lysosomal pathway (ALP) and overexpression of TFEB was suggested for the treatment of ALP-related diseases that often affect the heart. However, TFEB-mediated ALP induction may perturb cardiac stress response. We used adeno-associated viral vectors type 9 (AAV9) to overexpress TFEB (AAV9-Tfeb) or Luciferase-control (AAV9-Luc) in cardiomyocytes of 12-week-old male mice. Mice were subjected to transverse aortic constriction (TAC, 27G; AAV9-Luc:

Identifiants

DOI: 10.3390/ijms23115943 PMID: 35682624 PMC: PMC9180101
pubmed: 35682624
pii: ijms23115943
doi: 10.3390/ijms23115943
pmc: PMC9180101
pii:
doi:

Substances chimiques

Basic Helix-Loop-Helix Leucine Zipper Transcription Factors 0
Tcfeb protein, mouse 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Deutsche Forschungsgemeinschaft
ID : FI 965/5-1
Organisme : Deutsche Forschungsgemeinschaft
ID : FI 965/5-2
Organisme : German Centre for Cardiovascular Research
ID : 81X2500129
Organisme : German Centre for Cardiovascular Research
ID : 81Z5400153

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Auteurs

Sebastian Wundersitz (S)

Experimental and Clinical Research Center (ECRC), Max Delbrück Center (MDC) for Molecular Medicine in the Helmholtz Association, Charité-Universitätsmedizin Berlin, 13125 Berlin, Germany.
DZHK (German Center for Cardiovascular Research), Partner Site Berlin, 10785 Berlin, Germany.
ORCID: 0000-0001-8103-6029

Cristina Pablo Tortola (C)

Experimental and Clinical Research Center (ECRC), Max Delbrück Center (MDC) for Molecular Medicine in the Helmholtz Association, Charité-Universitätsmedizin Berlin, 13125 Berlin, Germany.

Sibylle Schmidt (S)

Experimental and Clinical Research Center (ECRC), Max Delbrück Center (MDC) for Molecular Medicine in the Helmholtz Association, Charité-Universitätsmedizin Berlin, 13125 Berlin, Germany.

Ramon Oliveira Vidal (R)

Laboratory of Functional Genomics, Nutrigenomics and Systems Biology, Max Delbrück Center (MDC) for Molecular Medicine in the Helmholtz Association, Berlin Institute for Medical Systems Biology, 10115 Berlin, Germany.
Berlin Institute of Health (BIH), 10178 Berlin, Germany.

Melanie Kny (M)

Experimental and Clinical Research Center (ECRC), Max Delbrück Center (MDC) for Molecular Medicine in the Helmholtz Association, Charité-Universitätsmedizin Berlin, 13125 Berlin, Germany.

Alexander Hahn (A)

Experimental and Clinical Research Center (ECRC), Max Delbrück Center (MDC) for Molecular Medicine in the Helmholtz Association, Charité-Universitätsmedizin Berlin, 13125 Berlin, Germany.

Lukas Zanders (L)

Experimental and Clinical Research Center (ECRC), Max Delbrück Center (MDC) for Molecular Medicine in the Helmholtz Association, Charité-Universitätsmedizin Berlin, 13125 Berlin, Germany.
ORCID: 0000-0003-0488-6243

Hugo A Katus (HA)

Department of Internal Medicine III, University Hospital Heidelberg, 69120 Heidelberg, Germany.
DZHK (German Centre for Cardiovascular Research), Partner Site Heidelberg/Mannheim, 69120 Heidelberg, Germany.

Sascha Sauer (S)

Laboratory of Functional Genomics, Nutrigenomics and Systems Biology, Max Delbrück Center (MDC) for Molecular Medicine in the Helmholtz Association, Berlin Institute for Medical Systems Biology, 10115 Berlin, Germany.
Berlin Institute of Health (BIH), 10178 Berlin, Germany.

Christian Butter (C)

Heart Center Brandenburg, Department of Cardiology, Medical University Brandenburg (MHB), 16321 Bernau, Germany.

Friedrich C Luft (FC)

Experimental and Clinical Research Center (ECRC), Max Delbrück Center (MDC) for Molecular Medicine in the Helmholtz Association, Charité-Universitätsmedizin Berlin, 13125 Berlin, Germany.

Oliver J Müller (OJ)

Department of Cardiology and Angiology, University Medical Center Schleswig-Holstein, 14105 Kiel, Germany.
DZHK (German Centre for Cardiovascular Research), Partner Site Hamburg/Kiel/Lübeck, 20251 Hamburg, Germany.
ORCID: 0000-0001-8223-2638

Jens Fielitz (J)

Experimental and Clinical Research Center (ECRC), Max Delbrück Center (MDC) for Molecular Medicine in the Helmholtz Association, Charité-Universitätsmedizin Berlin, 13125 Berlin, Germany.
DZHK (German Center for Cardiovascular Research), Partner Site Greifswald, 17475 Greifswald, Germany.
Department of Internal Medicine B, Cardiology, University Medicine Greifswald, 17475 Greifswald, Germany.
ORCID: 0000-0001-8522-1045

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › The Transcription Factor EB (TFEB) Sensitizes...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteurs de transcription à motif basique et à glissière à leucines › Facteurs de transcription à motifs basiques hélice-boucle-hélice et à glissière à leucines › The Transcription Factor EB (TFEB) Sensitizes...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › The Transcription Factor EB (TFEB) Sensitizes...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Techniques de diagnostic cardiovasculaire › Tests de la fonction cardiaque › Échocardiographie › The Transcription Factor EB (TFEB) Sensitizes...
questionsmedicales.fr › Maladies cardiovasculaires › Cardiopathies › Défaillance cardiaque › The Transcription Factor EB (TFEB) Sensitizes...
questionsmedicales.fr › États, signes et symptômes pathologiques › États anatomopathologiques › Hypertrophie › Cardiomégalie › Hypertrophie ventriculaire gauche › The Transcription Factor EB (TFEB) Sensitizes...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › The Transcription Factor EB (TFEB) Sensitizes...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › The Transcription Factor EB (TFEB) Sensitizes...
questionsmedicales.fr › Cellules › Cellules musculaires › Myocytes cardiaques › The Transcription Factor EB (TFEB) Sensitizes...
questionsmedicales.fr › Maladies cardiovasculaires › Cardiopathies › Dysfonction ventriculaire › Dysfonction ventriculaire gauche › The Transcription Factor EB (TFEB) Sensitizes...
questionsmedicales.fr › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiologiques cardiovasculaires › Fonction ventriculaire › Remodelage ventriculaire › The Transcription Factor EB (TFEB) Sensitizes...