Ibuprofen Favors Binding of Amyloid-β Peptide to Its Depot, Serum Albumin.
Alzheimer’s disease
Aβ fibrillation
amyloid-β peptide
electron microscopy
human serum albumin
ibuprofen
molecular docking
surface plasmon resonance
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
31 May 2022
31 May 2022
Historique:
received:
15
04
2022
revised:
24
05
2022
accepted:
28
05
2022
entrez:
10
6
2022
pubmed:
11
6
2022
medline:
14
6
2022
Statut:
epublish
Résumé
The deposition of amyloid-β peptide (Aβ) in the brain is a critical event in the progression of Alzheimer's disease (AD). This Aβ deposition could be prevented by directed enhancement of Aβ binding to its natural depot, human serum albumin (HSA). Previously, we revealed that specific endogenous ligands of HSA improve its affinity to monomeric Aβ. We show here that an exogenous HSA ligand, ibuprofen (IBU), exerts the analogous effect. Plasmon resonance spectroscopy data evidence that a therapeutic IBU level increases HSA affinity to monomeric Aβ
Identifiants
pubmed: 35682848
pii: ijms23116168
doi: 10.3390/ijms23116168
pmc: PMC9181795
pii:
doi:
Substances chimiques
Amyloid beta-Peptides
0
Ligands
0
Peptide Fragments
0
Serum Albumin
0
Ibuprofen
WK2XYI10QM
Serum Albumin, Human
ZIF514RVZR
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Russian Science Foundation
ID : 20-74-10072
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