Identification of New Non-BBB Permeable Tryptophan Hydroxylase Inhibitors for Treating Obesity and Fatty Liver Disease.
fatty liver
obesity
treatment
tryptophan hydroxylase inhibitor
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
25 May 2022
25 May 2022
Historique:
received:
31
03
2022
revised:
23
05
2022
accepted:
23
05
2022
entrez:
10
6
2022
pubmed:
11
6
2022
medline:
14
6
2022
Statut:
epublish
Résumé
Serotonin (5-hydroxytryptophan) is a hormone that regulates emotions in the central nervous system. However, serotonin in the peripheral system is associated with obesity and fatty liver disease. Because serotonin cannot cross the blood-brain barrier (BBB), we focused on identifying new tryptophan hydroxylase type I (TPH1) inhibitors that act only in peripheral tissues for treating obesity and fatty liver disease without affecting the central nervous system. Structural optimization inspired by
Identifiants
pubmed: 35684355
pii: molecules27113417
doi: 10.3390/molecules27113417
pmc: PMC9182086
pii:
doi:
Substances chimiques
Serotonin
333DO1RDJY
Tryptophan Hydroxylase
EC 1.14.16.4
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : National Research Foundation of Korea
ID : 2016M3A9B6902868
Organisme : National Research Foundation of Korea
ID : 2021R1A2C2008062
Organisme : Korea Institute of Energy Technology Evaluation and Planning
ID : 20202020800330
Références
Proc Natl Acad Sci U S A. 1994 Jan 4;91(1):68-72
pubmed: 8278409
Eur J Med Chem. 2001 Sep;36(9):719-30
pubmed: 11672881
J Comput Chem. 2009 Dec;30(16):2785-91
pubmed: 19399780
Nat Med. 2015 Feb;21(2):166-72
pubmed: 25485911
Drugs. 2017 May;77(7):793-798
pubmed: 28382568
J Affect Disord. 2007 Nov;103(1-3):43-62
pubmed: 17363069
Eur J Med Chem. 2003 Mar;38(3):223-32
pubmed: 12667689
Curr Chem Genomics. 2010 Apr 14;4:19-26
pubmed: 20556201
J Pharm Sci. 1999 Aug;88(8):815-21
pubmed: 10430548
J Med Chem. 2008 Jul 10;51(13):3684-7
pubmed: 18557609
Bioorg Med Chem Lett. 2017 Feb 1;27(3):413-419
pubmed: 28041831
Sleep Med Rev. 2011 Aug;15(4):269-81
pubmed: 21459634
Front Physiol. 2018 Feb 20;9:85
pubmed: 29515452
Mol Cells. 2015 Dec;38(12):1023-8
pubmed: 26628041
Pharmacol Biochem Behav. 2010 Nov;97(1):84-91
pubmed: 20837046
Pharmacol Biochem Behav. 2002 Apr;71(4):857-65
pubmed: 11888576
Pharm Biotechnol. 1996;8:239-58
pubmed: 8791813
J Med Chem. 1980 Jun;23(6):682-4
pubmed: 7392035
Nat Commun. 2015 Apr 13;6:6794
pubmed: 25864946
Annu Rev Med. 2009;60:355-66
pubmed: 19630576
J Med Chem. 2021 Jan 28;64(2):1037-1053
pubmed: 33417443
J Med Chem. 1988 Mar;31(3):656-71
pubmed: 2894467