Isoquinoline Alkaloid Contents in
HPLC-DAD
LC-MS/MS
Macleaya cordata
cholinesterase activity inhibition
isoquinoline alkaloids
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
03 Jun 2022
03 Jun 2022
Historique:
received:
29
04
2022
revised:
27
05
2022
accepted:
31
05
2022
entrez:
10
6
2022
pubmed:
11
6
2022
medline:
14
6
2022
Statut:
epublish
Résumé
An important strategy for treating neurodegenerative disorders is to maintain the levels of acetylcholine in the synaptic cleft by blocking the cholinesterases. Searching for new effective compounds with inhibited acetylcholinesterase and butyrylcholinesterase activity is one of the most significant challenges of the modern scientific research. The aim of this study was the optimization of the condition for cholinesterase activity determination by high-performance liquid chromatography coupled with diode array detector (HPLC-DAD) in terms of concentrations of enzymatic reaction mixture components, temperature of incubation, and incubation time. In vitro investigation of acetylcholinesterase and butyrylcholinesterase activity inhibition by some isoquinoline alkaloids and extracts obtained from the aerial part and roots of
Identifiants
pubmed: 35684539
pii: molecules27113606
doi: 10.3390/molecules27113606
pmc: PMC9182188
pii:
doi:
Substances chimiques
Alkaloids
0
Antineoplastic Agents
0
Cholinesterase Inhibitors
0
Isoquinolines
0
Plant Extracts
0
Acetylcholinesterase
EC 3.1.1.7
Butyrylcholinesterase
EC 3.1.1.8
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
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