Design, Synthesis, and Biological Evaluation of a Novel Series of 4-Guanidinobenzoate Derivatives as Enteropeptidase Inhibitors with Low Systemic Exposure for the Treatment of Obesity.
Journal
Journal of medicinal chemistry
ISSN: 1520-4804
Titre abrégé: J Med Chem
Pays: United States
ID NLM: 9716531
Informations de publication
Date de publication:
23 06 2022
23 06 2022
Historique:
pubmed:
11
6
2022
medline:
25
6
2022
entrez:
10
6
2022
Statut:
ppublish
Résumé
To discover a novel series of potent inhibitors of enteropeptidase, a membrane-bound serine protease localized to the duodenal brush border, 4-guanidinobenzoate derivatives were evaluated with minimal systemic exposure. The
Identifiants
pubmed: 35686954
doi: 10.1021/acs.jmedchem.2c00463
pmc: PMC9234964
doi:
Substances chimiques
Benzoates
0
Guanidines
0
4-guanidinobenzoate
16060-65-4
Enteropeptidase
EC 3.4.21.9
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
8456-8477Références
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