The Role of B Cells in Cardiomyopathy and Heart Failure.
B lymphocytes
Cardiac immunology
HFpEF
HFrEF
Journal
Current cardiology reports
ISSN: 1534-3170
Titre abrégé: Curr Cardiol Rep
Pays: United States
ID NLM: 100888969
Informations de publication
Date de publication:
08 2022
08 2022
Historique:
accepted:
16
05
2022
pubmed:
12
6
2022
medline:
30
7
2022
entrez:
11
6
2022
Statut:
ppublish
Résumé
To summarize the current knowledge on the role that B lymphocytes play in heart failure. Several studies from murine models have shown that B cells modulate cardiac adaptation to injury and ultimately affect the degree of cardiac dysfunction after acute ischemic damage. In addition, a B cell-modulating small molecule was recently shown to have beneficial effects in humans with heart failure with preserved ejection fraction. B lymphocytes are specialized immune cells present in all jawed vertebrates. They are characteristically known for their ability to produce antibodies, but they have other functions and are important players in virtually all forms of immune responses. A growing body of evidence indicates that B cells are intimately connected with the heart and that B cell dysregulation might play a role in the pathogenesis and progression of both heart failure with reduced ejection fraction and heart failure with preserved ejection fraction. B cells are therefore gathering attention as potential targets for the development of novel immunomodulatory-based treatments for heart failure.
Identifiants
pubmed: 35689723
doi: 10.1007/s11886-022-01722-4
pii: 10.1007/s11886-022-01722-4
pmc: PMC9422953
mid: NIHMS1816653
doi:
Types de publication
Journal Article
Review
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
935-946Subventions
Organisme : NHLBI NIH HHS
ID : K08 HL145108
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL160716
Pays : United States
Informations de copyright
© 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
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