Methyltransferases: Functions and Applications.
S-adenosyl-l-methionine
biocatalysis
enzymes
methyltransferases
Journal
Chembiochem : a European journal of chemical biology
ISSN: 1439-7633
Titre abrégé: Chembiochem
Pays: Germany
ID NLM: 100937360
Informations de publication
Date de publication:
16 09 2022
16 09 2022
Historique:
revised:
10
06
2022
received:
14
04
2022
pubmed:
13
6
2022
medline:
20
9
2022
entrez:
12
6
2022
Statut:
ppublish
Résumé
In this review the current state-of-the-art of S-adenosylmethionine (SAM)-dependent methyltransferases and SAM are evaluated. Their structural classification and diversity is introduced and key mechanistic aspects presented which are then detailed further. Then, catalytic SAM as a target for drugs, and approaches to utilise SAM as a cofactor in synthesis are introduced with different supply and regeneration approaches evaluated. The use of SAM analogues are also described. Finally O-, N-, C- and S-MTs, their synthetic applications and potential for compound diversification is given.
Identifiants
pubmed: 35691829
doi: 10.1002/cbic.202200212
pmc: PMC9539859
doi:
Substances chimiques
S-Adenosylmethionine
7LP2MPO46S
Methyltransferases
EC 2.1.1.-
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e202200212Subventions
Organisme : Wellcome Trust
ID : 219857/Z/19/Z
Pays : United Kingdom
Informations de copyright
© 2022 The Authors. ChemBioChem published by Wiley-VCH GmbH.
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