The Diverse Major Histocompatibility Complex Haplotypes of a Common Commercial Chicken Line and Their Effect on Marek's Disease Virus Pathogenesis and Tumorigenesis.
B15
B19
B21
B9
VALO
major histocompatibility complex (MHC)
resistance
susceptibility
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2022
2022
Historique:
received:
30
03
2022
accepted:
29
04
2022
entrez:
13
6
2022
pubmed:
14
6
2022
medline:
15
6
2022
Statut:
epublish
Résumé
The major histocompatibility complex (MHC) is crucial for appropriate immune responses against invading pathogens. Chickens possess a single predominantly-expressed class I molecule with strong associations between disease resistance and MHC haplotype. For Marek's disease virus (MDV) infections of chickens, the MHC haplotype is one of the major determinants of genetic resistance and susceptibility. VALO specific pathogen free (SPF) chickens are widely used in biomedical research and vaccine production. While valuable findings originate from MDV infections of VALO SPF chickens, their MHC haplotypes and associated disease resistance remained elusive. In this study, we used several typing systems to show that VALO SPF chickens possess MHC haplotypes that include B9, B9:02, B15, B19 and B21 at various frequencies. Moreover, we associate the MHC haplotypes to MDV-induced disease and lymphoma formation and found that B15 homozygotes had the lowest tumor incidence while B21 homozygotes had the lowest number of organs with tumors. Finally, we found transmission at variable levels to all contact birds except B15/B21 heterozygotes. These data have immediate implications for the use of VALO SPF chickens and eggs in the life sciences and add another piece to the puzzle of the chicken MHC complex and its role in infections with this oncogenic herpesvirus.
Identifiants
pubmed: 35693787
doi: 10.3389/fimmu.2022.908305
pmc: PMC9186122
doi:
Substances chimiques
Histocompatibility Antigens
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
908305Subventions
Organisme : Wellcome Trust
ID : 110106/Z/15/Z
Pays : United Kingdom
Informations de copyright
Copyright © 2022 Bertzbach, Tregaskes, Martin, Deumer, Huynh, Kheimar, Conradie, Trimpert, Kaufman and Kaufer.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Transbound Emerg Dis. 2013 Nov;60 Suppl 2:51-62
pubmed: 24589102
Oncogene. 2019 Mar;38(10):1778-1786
pubmed: 30846849
J Vis Exp. 2015 Mar 19;(97):
pubmed: 25867050
Vaccine. 2007 May 10;25(19):3792-9
pubmed: 17321645
Vaccines (Basel). 2020 Sep 05;8(3):
pubmed: 32899581
Proc Natl Acad Sci U S A. 2006 Jan 31;103(5):1434-9
pubmed: 16432226
Biol Open. 2018 Jan 17;7(1):
pubmed: 29183907
Vet Microbiol. 2019 Dec;239:108462
pubmed: 31767100
J Virol. 2021 Jul 12;95(15):e0013121
pubmed: 34011541
J Virol. 2000 Dec;74(23):11088-98
pubmed: 11070004
Nature. 1999 Oct 28;401(6756):923-5
pubmed: 10553909
Folia Biol (Praha). 2000;46(1):17-23
pubmed: 10730878
J Virol. 2014 Dec;88(24):14138-47
pubmed: 25275118
Avian Pathol. 2020 Dec;49(6):666-677
pubmed: 32907345
Curr Top Microbiol Immunol. 2001;255:121-41
pubmed: 11217420
Science. 1977 Jan 14;195(4274):193-5
pubmed: 831269
Sci Rep. 2018 Jan 9;8(1):209
pubmed: 29317752
Immunogenetics. 2006 Jun;58(5-6):407-21
pubmed: 16738938
J Virol. 2021 Jan 13;95(3):
pubmed: 33115875
Poult Sci. 1982 Feb;61(2):205-11
pubmed: 7088788
J Gen Virol. 2018 Aug 01;:
pubmed: 30067172
Nat Rev Microbiol. 2006 Apr;4(4):283-94
pubmed: 16541136
Nat Microbiol. 2019 Dec;4(12):2175-2183
pubmed: 31477893
Immunogenetics. 2004 Jul;56(4):261-79
pubmed: 15257423
Avian Dis. 1990 Oct-Dec;34(4):818-23
pubmed: 2282011
Anim Genet. 1993 Aug;24(4):283-7
pubmed: 7902041
PLoS Pathog. 2020 Dec 11;16(12):e1009104
pubmed: 33306739
Science. 1983 Feb 25;219(4587):977-9
pubmed: 6823560
BMC Genomics. 2009 Jan 14;10:20
pubmed: 19144166
Proc Natl Acad Sci U S A. 2001 Jul 31;98(16):9203-8
pubmed: 11470922
Proc Natl Acad Sci U S A. 2009 Sep 29;106(39):16740-5
pubmed: 19805366
Poult Sci. 2016 Feb;95(2):375-92
pubmed: 26740135
J Virol. 2018 Nov 12;92(23):
pubmed: 30209177
J Immunol. 1992 Mar 1;148(5):1532-46
pubmed: 1538136
PLoS Biol. 2021 Apr 26;19(4):e3001057
pubmed: 33901176
Mol Immunol. 2021 Jul;135:12-20
pubmed: 33845329
Crit Rev Immunol. 1992;12(1-2):47-79
pubmed: 1358107
Poult Sci. 1983 Apr;62(4):573-8
pubmed: 6306630
Rev Sci Tech. 2016 Apr;35(1):105-19
pubmed: 27217172
Antiviral Res. 2019 Nov;171:104606
pubmed: 31520682
Immunogenetics. 1982;16(6):513-32
pubmed: 6763913
Vet Pathol. 2001 Mar;38(2):129-42
pubmed: 11280369
Trends Immunol. 2018 May;39(5):367-379
pubmed: 29396014
J Virol. 2014 Mar;88(5):2835-43
pubmed: 24371053
Genetics. 2007 Dec;177(4):2417-31
pubmed: 18073438
Cancers (Basel). 2020 Mar 10;12(3):
pubmed: 32164311
mSphere. 2019 Oct 9;4(5):
pubmed: 31597721
Immunogenetics. 2020 Feb;72(1-2):9-24
pubmed: 31741010
Antiviral Res. 2016 Sep;133:242-9
pubmed: 27498036
Avian Dis. 2013 Jun;57(2 Suppl):498-502
pubmed: 23901767
Dev Cell. 2005 Jan;8(1):9-17
pubmed: 15621526
Genes (Basel). 2021 Sep 30;12(10):
pubmed: 34680960
J Virol. 2012 Aug;86(16):8536-45
pubmed: 22647701
J Virol. 2022 Mar 23;96(6):e0202721
pubmed: 35107377
Br Poult Sci. 2003 Mar;44(1):6-21
pubmed: 12737220
Avian Dis. 1993 Jan-Mar;37(1):53-9
pubmed: 8383961
Avian Pathol. 1986;15(4):769-82
pubmed: 18766578
Anim Genet. 1999 Apr;30(2):126-35
pubmed: 10376303