Health benefits of polyphenols: A concise review.
antioxidant
functional foods
gut microbiome
polyphenols
Journal
Journal of food biochemistry
ISSN: 1745-4514
Titre abrégé: J Food Biochem
Pays: United States
ID NLM: 7706045
Informations de publication
Date de publication:
10 2022
10 2022
Historique:
revised:
01
05
2022
received:
22
02
2022
accepted:
23
05
2022
pubmed:
14
6
2022
medline:
13
10
2022
entrez:
13
6
2022
Statut:
ppublish
Résumé
Plants produce polyphenols, which are considered highly essential functional foods in our diet. They are classified into several groups according to their diverse chemical structures. Flavanoids, lignans, stilbenes, and phenolic acids are the four main families of polyphenols. Several in vivo and in vitro research have been conducted so far to evaluate their health consequences. Polyphenols serve a vital function in the protection of the organism from external stimuli and in eliminating reactive oxygen species (ROS), which are instigators of several illnesses. Polyphenols are present in tea, chocolate, fruits, and vegetables with the potential to positively influence human health. For instance, cocoa flavan-3-ols have been associated with a decreased risk of myocardial infarction, stroke, and diabetes. Polyphenols in the diet also help to improve lipid profiles, blood pressure, insulin resistance, and systemic inflammation. Quercetin, a flavonoid, and resveratrol, a stilbene, have been linked to improved cardiovascular health. Dietary polyphenols potential to elicit therapeutic effects might be attributed, at least in part, to a bidirectional association with the gut microbiome. This is because polyphenols are known to affect the gut microbiome composition in ways that lead to better human health. Specifically, the gut microbiome converts polyphenols into bioactive compounds that have therapeutic effects. In this review, the antioxidant, cytotoxicity, anti-inflammatory, antihypertensive, and anti-diabetic actions of polyphenols are described based on findings from in vivo and in vitro experimental trials. PRACTICAL APPLICATIONS: The non-communicable diseases (NCDs) burden has been increasing worldwide due to the sedentary lifestyle and several other factors such as smoking, junk food, etc. Scientific literature evidence supports the use of plant-based food polyphenols as therapeutic agents that could help to alleviate NCD's burden. Thus, consuming polyphenolic compounds from natural sources could be an effective solution to mitigate NCDs concerns. It is also discussed how natural antioxidants from medicinal plants might help prevent or repair damage caused by free radicals, such as oxidative stress.
Substances chimiques
Anti-Inflammatory Agents
0
Antihypertensive Agents
0
Antioxidants
0
Flavonoids
0
Lignans
0
Lipids
0
Polyphenols
0
Reactive Oxygen Species
0
Stilbenes
0
Tea
0
Quercetin
9IKM0I5T1E
Resveratrol
Q369O8926L
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e14264Subventions
Organisme : The author (Ananya) is thankful to the DST-INSPIRE Fellowship program (Application reference number- DST/INSPIRE/03/2021/001914) India for the award of Junior Research Fellowship (financial support). The author (Mrinal Samtiya) is thankful to the Haryana state council for science innovation and technology (HSCSIT/R&D/2021/461) India, for the award of Junior Research Fellowship (financial support).
Informations de copyright
© 2022 Wiley Periodicals LLC.
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